Howick et al., 2017
The genetic architecture of defence as resistance to and tolerance of bacterial infection in Drosophila melanogaster
[10.1111/mec.14017][FBrf0235063]

Description

Defense against pathogenic infection can take two forms: resistance and tolerance. Resistance is the ability of the host to limit a pathogen burden, whereas tolerance is the ability to limit the negative consequences of infection at a given level of infection intensity. This study performed a genomewide association study to map the genetic basis of variation in resistance to and tolerance of infection of five- to nine-day-old mated female flies, which were infected with the Gram-negative bacterium Providencia rettgeri. The results of the study indicate that tolerance is not an independent strategy from resistance.

Comments from curator

Phenotyping data were extracted from the Table S1 in the Supporting Information section.

The definition of "Tolerance" and how it is calculated in this study is explained in the first Result section of the paper.

168 DGRP lines 148 available 10 genotyped 10 unavailable

DGRP_026 DGRP_028 DGRP_038 DGRP_040 DGRP_042 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_080 DGRP_083 DGRP_085 DGRP_088 DGRP_093 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_176 DGRP_177 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_301 DGRP_304 DGRP_306 DGRP_307 DGRP_309 DGRP_315 DGRP_317 DGRP_318 DGRP_319 DGRP_320 DGRP_321 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_373 DGRP_374 DGRP_377 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_392 DGRP_393 DGRP_398 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_476 DGRP_486 DGRP_491 DGRP_492 DGRP_502 DGRP_508 DGRP_513 DGRP_514 DGRP_530 DGRP_535 DGRP_554 DGRP_555 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_703 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_750 DGRP_761 DGRP_765 DGRP_771 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_857 DGRP_859 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_913

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	5 phenotypes BacterialLoad_PR BacterialLoad_PR_ADJ Tolerance_PRettgeri pc_Surv_PRettgeri pc_Surv_PRettgeriADJ	168 DGRP lines DGRP_026 DGRP_028 DGRP_038 DGRP_040 DGRP_042 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_080 DGRP_083 DGRP_085 DGRP_088 DGRP_093 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_176 DGRP_177 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_301 DGRP_304 DGRP_306 DGRP_307 DGRP_309 DGRP_315 DGRP_317 DGRP_318 DGRP_319 DGRP_320 DGRP_321 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_373 DGRP_374 DGRP_377 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_392 DGRP_393 DGRP_398 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_476 DGRP_486 DGRP_491 DGRP_492 DGRP_502 DGRP_508 DGRP_513 DGRP_514 DGRP_530 DGRP_535 DGRP_554 DGRP_555 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_703 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_750 DGRP_761 DGRP_765 DGRP_771 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_857 DGRP_859 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_913	Download