Najarro et al., 2015
Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila
[10.1371/journal.pgen.1005663][FBrf0230275]

Description

Living organisms are subjected to a barrage of toxic compounds, or xenobiotics, in their environment and their diet. Natural populations exhibit a great deal of interindividual genetic variation in the response to toxins, exemplified by the variable clinical efficacy of pharmaceutical drugs in humans, and the evolution of pesticide-resistant insects. This study measured xenobiotic resistance, using caffeine as a model toxic compound.

Comments from curator

Phenotyping data was taken from the S5 Table in the Supporting information section.

Of note, this study uses both flies from the DGRP and flies from another set of Recombinant Inbred Lines (RILs) called DSPR. Of course, we only extracted data corresponding to the DGRP lines, except the line with Bloomington stock number 34061, because we could not find the corresponding DGRP id.

164 DGRP lines 6 unavailable 149 available 9 genotyped

DGRP_026 DGRP_028 DGRP_038 DGRP_041 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_105 DGRP_109 DGRP_129 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_189 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_237 DGRP_239 DGRP_256 DGRP_272 DGRP_280 DGRP_301 DGRP_303 DGRP_306 DGRP_307 DGRP_309 DGRP_310 DGRP_315 DGRP_317 DGRP_318 DGRP_320 DGRP_321 DGRP_324 DGRP_325 DGRP_332 DGRP_335 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_377 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_392 DGRP_398 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_443 DGRP_461 DGRP_476 DGRP_486 DGRP_491 DGRP_502 DGRP_513 DGRP_530 DGRP_531 DGRP_535 DGRP_554 DGRP_555 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_646 DGRP_703 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_757 DGRP_761 DGRP_774 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_818 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_857 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913

Datasets

Dataset	Phenotypes	DGRP lines
Raw dataset #1	1 phenotypes Lifespan_Caffeine	164 DGRP lines DGRP_026 DGRP_028 DGRP_038 DGRP_041 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_105 DGRP_109 DGRP_129 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_189 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_237 DGRP_239 DGRP_256 DGRP_272 DGRP_280 DGRP_301 DGRP_303 DGRP_306 DGRP_307 DGRP_309 DGRP_310 DGRP_315 DGRP_317 DGRP_318 DGRP_320 DGRP_321 DGRP_324 DGRP_325 DGRP_332 DGRP_335 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_377 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_392 DGRP_398 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_443 DGRP_461 DGRP_476 DGRP_486 DGRP_491 DGRP_502 DGRP_513 DGRP_530 DGRP_531 DGRP_535 DGRP_554 DGRP_555 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_646 DGRP_703 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_757 DGRP_761 DGRP_774 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_818 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_857 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913	Download