Dembeck et al., 2015
Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster
[10.7554/eLife.09861][FBrf0230707]

Description

Cuticular HydroCarbons (or CHCs) are the most common fat molecules in the epicuticle. It's a group of long-chain hydrocarbons that are produced and secreted by the epidermis (outer layer of skin) and play an important role in protecting the insect’s body from desiccation in dry habitats. They also serve as chemical signals that mediate social interactions and behavior. This study looks into CHC composition as a species-specific blend of fatty acid-derived apolar lipids on the epicuticle and uncovered 24 genes that may be involved in CHC manufacture.

Comments from curator

Linear alkanes are referred to by the abbreviation n-Cx, where ‘‘x’’ is the total carbon number. For example, tricosane is designated n-C23.
Methyl-branched alkanes are referred to with a y-Me-Cx prefix, where 'y' is the carbon onto which the methyl group is bound. For example, 9-Me-C23 is a 23 carbon chain with a methyl on the 9th carbon.
For monoenes (z-Cx:1) and dienes (z,z-Cx:2) the number of double bonds is indicated after the colon and the double bond position/s are 'z' or 'z,z"). For example, 7-C23:1 has one double bond between the 7^th and 8^th carbons.

All CHCs are depicted in more details in Table 1

Of note, the data corresponds only to the Proportion of Total CHCs which is depicted in Figure 2B and 2C. The raw signal strength (in pA = picoAmperes) detection for each CHC is NOT available. So Figures like Figure 1 and Figure 2A are NOT reproducible.

Phenotyping data is available from Supplementary file 1: elife-09861-supp1-v3.xlsx

170 DGRP lines 170 genotyped

DGRP_021 DGRP_026 DGRP_028 DGRP_031 DGRP_038 DGRP_040 DGRP_041 DGRP_042 DGRP_045 DGRP_048 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_100 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_280 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_309 DGRP_310 DGRP_313 DGRP_315 DGRP_318 DGRP_320 DGRP_321 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_486 DGRP_491 DGRP_502 DGRP_508 DGRP_509 DGRP_517 DGRP_530 DGRP_531 DGRP_535 DGRP_551 DGRP_555 DGRP_559 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_639 DGRP_642 DGRP_646 DGRP_703 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_761 DGRP_765 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_818 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_861 DGRP_913

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	66 phenotypes Cuticul_11_9_Me_C23 Cuticul_13_11_Me_C25 Cuticul_2_Me_C22 Cuticul_2_Me_C24 Cuticul_2_Me_C25 Cuticul_2_Me_C26 Cuticul_2_Me_C26_C27 Cuticul_2_Me_C27_C28 Cuticul_2_Me_C28_C29 Cuticul_2_Me_C29_C30 Cuticul_2_Me_C30 Cuticul_3_Me_C23 Cuticul_3_Me_C23_C24 Cuticul_3_Me_C25 Cuticul_3_Me_C25_C26 Cuticul_3_Me_C27_C28 Cuticul_5_9_C25_1_2 Cuticul_5_9_C27_1_2 Cuticul_5_9_C29_1_2 Cuticul_5_C23_1 Cuticul_5_C24_1 Cuticul_5_C25_1 Cuticul_5_C27_1 Cuticul_5_Me_C25 Cuticul_6_10_C25_2 Cuticul_6_10_C26_2 Cuticul_6_C23_1 Cuticul_6_C24_1 Cuticul_6_C26_1 Cuticul_7_11_C23_2 Cuticul_7_11_C24_2 Cuticul_7_11_C25_2 Cuticul_7_11_C26_2 Cuticul_7_11_C31_2 Cuticul_7_C23_1 Cuticul_7_C24_1 Cuticul_7_C25_1 Cuticul_7_C26_1 Cuticul_7_C27_1 Cuticul_7_C29_1 Cuticul_8_12_C26_2 Cuticul_8_12_C28_2 Cuticul_8_C25_1 Cuticul_9_13_C25_2 Cuticul_9_13_C27_2 Cuticul_9_C23_1 Cuticul_9_C25_1 Cuticul_NI_20 Cuticul_NI_33 Cuticul_NI_34 Cuticul_NI_54 Cuticul_NI_7 Cuticul_n_C21 Cuticul_n_C22 Cuticul_n_C23 Cuticul_n_C24 Cuticul_n_C25 Cuticul_n_C26 Cuticul_n_C27 Cuticul_n_C28 Cuticul_n_C29 Cuticul_n_C31 Cuticul_x_C22_1_l2 Cuticul_x_C22_1_l3 Cuticul_x_C23_1 Cuticul_x_y_C24_2	170 DGRP lines DGRP_021 DGRP_026 DGRP_028 DGRP_031 DGRP_038 DGRP_040 DGRP_041 DGRP_042 DGRP_045 DGRP_048 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_100 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_280 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_309 DGRP_310 DGRP_313 DGRP_315 DGRP_318 DGRP_320 DGRP_321 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_486 DGRP_491 DGRP_502 DGRP_508 DGRP_509 DGRP_517 DGRP_530 DGRP_531 DGRP_535 DGRP_551 DGRP_555 DGRP_559 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_639 DGRP_642 DGRP_646 DGRP_703 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_727 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_761 DGRP_765 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_812 DGRP_818 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_853 DGRP_855 DGRP_861 DGRP_913	Download