Vonesch et al., 2016
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster
[10.1371/journal.pgen.1005616][FBrf0230608]

Description

This study performed GWA of organismal size traits and found that the top associated variants differ between traits and sexes, and can only be linked to canonical growth pathway genes by epistasis analysis. The results of this study identified a cluster of associations close to the kek1 locus, a well-characterized growth regulator.

Comments from curator

Raw phenotypic data comes from Table S2 in the Supporting information section.

Centroid size was measured as the square root of the summed squared distances of 14 landmarks from the center of the wing. The interocular distance was measured from eye edge to eye edge along the anterior edge of the posterior ocelli and parallel to the base of the head.

Of note: Most of the phenotypes are not well described in the paper, and there are no units. They were asked to the authors or inferred by the curator.

149 DGRP lines 143 genotyped 6 not_genotyped

DGRP_021 DGRP_026 DGRP_028 DGRP_040 DGRP_057 DGRP_069 DGRP_073 DGRP_075 DGRP_085 DGRP_088 DGRP_091 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_176 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_272 DGRP_280 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_307 DGRP_309 DGRP_310 DGRP_313 DGRP_315 DGRP_318 DGRP_321 DGRP_324 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_375 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_398 DGRP_399 DGRP_405 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_476 DGRP_491 DGRP_492 DGRP_502 DGRP_509 DGRP_530 DGRP_531 DGRP_535 DGRP_554 DGRP_555 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_703 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_761 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_810 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_853 DGRP_855 DGRP_857 DGRP_859 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913

Datasets

Dataset	Phenotypes	DGRP lines
Raw dataset #1	27 phenotypes Eye_Area Eye_Interocular_Dist Head_Width Shoulder_Width Thorax_Length Wing_ACV_Length Wing_Anterior_to_L2 Wing_Area Wing_CentroidSize Wing_Intervein_Area1 Wing_Intervein_Area2 Wing_Intervein_Area3 Wing_Intervein_Area4 Wing_Intervein_Area5 Wing_Intervein_Area6 Wing_Intervein_Area7 Wing_Intervein_Area8 Wing_L1_Vein_Length Wing_L2_Vein_Length Wing_L3_Vein_Length Wing_L4_Vein_Length Wing_L5_Vein_Length Wing_L6_Vein_Length Wing_Length Wing_PCV_Length Wing_Posterior_to_L5 Wing_Width	149 DGRP lines DGRP_021 DGRP_026 DGRP_028 DGRP_040 DGRP_057 DGRP_069 DGRP_073 DGRP_075 DGRP_085 DGRP_088 DGRP_091 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_176 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_272 DGRP_280 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_307 DGRP_309 DGRP_310 DGRP_313 DGRP_315 DGRP_318 DGRP_321 DGRP_324 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_371 DGRP_373 DGRP_374 DGRP_375 DGRP_378 DGRP_379 DGRP_380 DGRP_381 DGRP_382 DGRP_383 DGRP_385 DGRP_386 DGRP_387 DGRP_391 DGRP_398 DGRP_399 DGRP_405 DGRP_409 DGRP_426 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_476 DGRP_491 DGRP_492 DGRP_502 DGRP_509 DGRP_530 DGRP_531 DGRP_535 DGRP_554 DGRP_555 DGRP_563 DGRP_584 DGRP_589 DGRP_595 DGRP_642 DGRP_703 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_732 DGRP_737 DGRP_738 DGRP_748 DGRP_761 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_790 DGRP_796 DGRP_801 DGRP_802 DGRP_804 DGRP_805 DGRP_810 DGRP_819 DGRP_820 DGRP_821 DGRP_822 DGRP_832 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_853 DGRP_855 DGRP_857 DGRP_859 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_890 DGRP_892 DGRP_894 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913	Download