Chow et al., 2013
Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes
[10.1073/pnas.1307125110][FBrf0221713]

Description

This study measured the survival time in response to tunicamycin-induced endoplasmic reticulum (ER) stress in DGRP lines. Survival time was significantly associated with polymorphisms in candidate genes with known (i.e., Xbp1) and unknown roles in ER stress.

Comments from curator

Phenotyping data are available in sd01.xlsx

Some gene expressions are summarized in sd02.xlsx (not included in the phenotypes)

Other external data available

GSE46425 Microarray gene expression of male whole fly under different ER stress conditions

112 DGRP lines 109 genotyped 3 not_genotyped

DGRP_021 DGRP_026 DGRP_028 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_075 DGRP_080 DGRP_083 DGRP_085 DGRP_091 DGRP_093 DGRP_101 DGRP_105 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_227 DGRP_228 DGRP_233 DGRP_237 DGRP_239 DGRP_272 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_313 DGRP_315 DGRP_318 DGRP_319 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_360 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_383 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_427 DGRP_437 DGRP_440 DGRP_486 DGRP_492 DGRP_514 DGRP_517 DGRP_535 DGRP_555 DGRP_563 DGRP_589 DGRP_639 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_765 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_808 DGRP_812 DGRP_820 DGRP_822 DGRP_837 DGRP_852 DGRP_855 DGRP_879 DGRP_882 DGRP_884 DGRP_890

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	2 phenotypes ERStress_t50 hr_ERStress_Survival	112 DGRP lines DGRP_021 DGRP_026 DGRP_028 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_075 DGRP_080 DGRP_083 DGRP_085 DGRP_091 DGRP_093 DGRP_101 DGRP_105 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_227 DGRP_228 DGRP_233 DGRP_237 DGRP_239 DGRP_272 DGRP_287 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_313 DGRP_315 DGRP_318 DGRP_319 DGRP_324 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_360 DGRP_362 DGRP_365 DGRP_367 DGRP_370 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_383 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_427 DGRP_437 DGRP_440 DGRP_486 DGRP_492 DGRP_514 DGRP_517 DGRP_535 DGRP_555 DGRP_563 DGRP_589 DGRP_639 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_730 DGRP_732 DGRP_737 DGRP_738 DGRP_765 DGRP_774 DGRP_776 DGRP_783 DGRP_786 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_808 DGRP_812 DGRP_820 DGRP_822 DGRP_837 DGRP_852 DGRP_855 DGRP_879 DGRP_882 DGRP_884 DGRP_890	Download