Dobson et al., 2015
Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster
[10.1038/ncomms7312]

Description

This study examined the genetic basis for how gut microbiota affect five nutritional traits (weight, protein, lipid, glucose, and glycogen contents) in fruit flies. The authors found significant genotype-dependent variations in these traits when the microbiota were eliminated, identifying specific genetic polymorphisms associated with these variations and validating key genes involved in these microbiota-dependent nutritional effects. Additionally, they observed that the presence of the intracellular bacterium Wolbachia influenced glycogen content, with Wolbachia-positive lines showing higher glycogen levels compared to Wolbachia-free lines.

Comments from curator

Despite being a study about microbiota-dependent nutrition, we could not find any other phenotypes than the Wolbachia Status in this study?

Phenotyping data is available from Supp Table S6 in supplementary data section.

134 DGRP lines 126 genotyped 8 not_genotyped

DGRP_026 DGRP_028 DGRP_038 DGRP_041 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_080 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_235 DGRP_237 DGRP_239 DGRP_272 DGRP_280 DGRP_303 DGRP_304 DGRP_306 DGRP_309 DGRP_315 DGRP_317 DGRP_318 DGRP_321 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_357 DGRP_358 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_371 DGRP_373 DGRP_374 DGRP_377 DGRP_379 DGRP_380 DGRP_381 DGRP_385 DGRP_386 DGRP_392 DGRP_393 DGRP_398 DGRP_399 DGRP_405 DGRP_409 DGRP_426 DGRP_427 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_486 DGRP_492 DGRP_502 DGRP_513 DGRP_514 DGRP_531 DGRP_535 DGRP_554 DGRP_563 DGRP_584 DGRP_642 DGRP_703 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_737 DGRP_738 DGRP_748 DGRP_750 DGRP_765 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_796 DGRP_801 DGRP_805 DGRP_808 DGRP_810 DGRP_819 DGRP_821 DGRP_822 DGRP_837 DGRP_842 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_855 DGRP_857 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_887 DGRP_890 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	1 phenotypes WolbachiaStatus	134 DGRP lines DGRP_026 DGRP_028 DGRP_038 DGRP_041 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_080 DGRP_083 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_223 DGRP_227 DGRP_228 DGRP_235 DGRP_237 DGRP_239 DGRP_272 DGRP_280 DGRP_303 DGRP_304 DGRP_306 DGRP_309 DGRP_315 DGRP_317 DGRP_318 DGRP_321 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_350 DGRP_352 DGRP_357 DGRP_358 DGRP_360 DGRP_361 DGRP_362 DGRP_365 DGRP_367 DGRP_371 DGRP_373 DGRP_374 DGRP_377 DGRP_379 DGRP_380 DGRP_381 DGRP_385 DGRP_386 DGRP_392 DGRP_393 DGRP_398 DGRP_399 DGRP_405 DGRP_409 DGRP_426 DGRP_427 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_486 DGRP_492 DGRP_502 DGRP_513 DGRP_514 DGRP_531 DGRP_535 DGRP_554 DGRP_563 DGRP_584 DGRP_642 DGRP_703 DGRP_712 DGRP_714 DGRP_716 DGRP_721 DGRP_737 DGRP_738 DGRP_748 DGRP_750 DGRP_765 DGRP_776 DGRP_783 DGRP_786 DGRP_787 DGRP_796 DGRP_801 DGRP_805 DGRP_808 DGRP_810 DGRP_819 DGRP_821 DGRP_822 DGRP_837 DGRP_842 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_855 DGRP_857 DGRP_861 DGRP_879 DGRP_882 DGRP_884 DGRP_887 DGRP_890 DGRP_897 DGRP_900 DGRP_907 DGRP_908 DGRP_911 DGRP_913	Download