Grubbs et al., 2013
New Components of Drosophila Leg Development Identified through Genome Wide Association Studies
[10.1371/journal.pone.0060261][FBrf0221227]

Description

This study focused on leg and antenna development from imaginal discs. They identified additional genes and genetic pathways involved in leg imaginal disc development. In particular, five genes that, when their function is reduced by RNAi, cause an antenna-to-leg transformation.

Comments from curator

Phenotyping data come from Table S1 in the Supporting Information section. I've manually separated the table (which has data per fly, with 24 replicates per sex for each line) into T1 (first) and T2 (second thoracic leg) phenotypes.

Measurements of the legs were recorded using Adobe Photoshop and ImageJ. Measurements of the femur, tibia, and tarsal segments were recorded separately. Of note, I could not find in the paper what was the unit for the measurements?

117 DGRP lines 109 available 8 genotyped

DGRP_021 DGRP_026 DGRP_028 DGRP_041 DGRP_042 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_280 DGRP_287 DGRP_310 DGRP_313 DGRP_318 DGRP_320 DGRP_325 DGRP_338 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_362 DGRP_365 DGRP_367 DGRP_371 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_383 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_492 DGRP_513 DGRP_517 DGRP_535 DGRP_555 DGRP_589 DGRP_639 DGRP_642 DGRP_646 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_730 DGRP_732 DGRP_737 DGRP_757 DGRP_765 DGRP_774 DGRP_783 DGRP_786 DGRP_787 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_805 DGRP_808 DGRP_812 DGRP_818 DGRP_820 DGRP_837 DGRP_852 DGRP_855 DGRP_857 DGRP_859 DGRP_861 DGRP_879 DGRP_890 DGRP_892 DGRP_894

Datasets

Dataset	Phenotypes	DGRP lines
Raw dataset #1	14 phenotypes Femur_Length_T1 Femur_Length_T2 Tarsus_Length_T1 Tarsus_Length_T2 Tibia_Length_T1 Tibia_Length_T2 Total_Leg_Length_T1 Total_Leg_Length_T2 pc_Femur_Leg_T1 pc_Femur_Leg_T2 pc_Tarsus_Leg_T1 pc_Tarsus_Leg_T2 pc_Tibia_Leg_T1 pc_Tibia_Leg_T2	117 DGRP lines DGRP_021 DGRP_026 DGRP_028 DGRP_041 DGRP_042 DGRP_045 DGRP_049 DGRP_057 DGRP_059 DGRP_069 DGRP_073 DGRP_075 DGRP_085 DGRP_088 DGRP_091 DGRP_093 DGRP_101 DGRP_105 DGRP_109 DGRP_129 DGRP_136 DGRP_138 DGRP_142 DGRP_149 DGRP_153 DGRP_158 DGRP_161 DGRP_176 DGRP_177 DGRP_181 DGRP_195 DGRP_208 DGRP_217 DGRP_227 DGRP_228 DGRP_229 DGRP_233 DGRP_235 DGRP_237 DGRP_239 DGRP_256 DGRP_280 DGRP_287 DGRP_310 DGRP_313 DGRP_318 DGRP_320 DGRP_325 DGRP_338 DGRP_350 DGRP_352 DGRP_356 DGRP_357 DGRP_358 DGRP_359 DGRP_362 DGRP_365 DGRP_367 DGRP_371 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_380 DGRP_383 DGRP_386 DGRP_391 DGRP_392 DGRP_399 DGRP_405 DGRP_406 DGRP_409 DGRP_427 DGRP_437 DGRP_439 DGRP_440 DGRP_492 DGRP_513 DGRP_517 DGRP_535 DGRP_555 DGRP_589 DGRP_639 DGRP_642 DGRP_646 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_730 DGRP_732 DGRP_737 DGRP_757 DGRP_765 DGRP_774 DGRP_783 DGRP_786 DGRP_787 DGRP_796 DGRP_799 DGRP_801 DGRP_802 DGRP_805 DGRP_808 DGRP_812 DGRP_818 DGRP_820 DGRP_837 DGRP_852 DGRP_855 DGRP_857 DGRP_859 DGRP_861 DGRP_879 DGRP_890 DGRP_892 DGRP_894	Download