Study

Curated
Chaston et al., 2016
Host Genetic Control of the Microbiota Mediates the Drosophila Nutritional Phenotype
[10.1128/AEM.03301-15][FBrf0230551]

Description

This study examined the impact of different microbiota on host nutritional indices (glucose, glycogen, triglyceride, and protein contents). Authors created gnotobiotic flies (containing defined microbiota) with different bacteria and found that multiple host genes were statistically associated with the abundance of one bacterium, Acetobacter tropicalis.

Comments from curator

Assignments to taxonomic ranks were performed in QIIME using the Greengenes database (class, order, family, genus, species). Operational taxonomic units (OTUs) were binned based on QIIME taxonomic assignments during correlation analysis and numbered from OTU001 to OTU176. It resulted in 76 OTUs (thus 76 phenotypes) after filtering.

Phenotyping data were extracted from Table S1B in zam999116867sd2.xlsx file in Supplemental material section. I’ve only included Table S1B, due to stricter selection/cutoffs than S1A. S1B was excluded due to the absence of all OTUs. Of note, this data only has 79 lines, while there are 126 lines described in Supp. Table S2.

The ratio data per 5 family types (Aceto., Lacto., Xantho., Coma., Other) were computed by the curator, using Table S1B in order to reproduce data used in Figure 1A.

The phenotyping data for nutritional traits (Glucose, ...), were not available, so we asked the authors, who provided it. They were added and contain an additional 30 lines (i.e. for a total of 109 lines, still not reaching the 126 lines described in Supp. Table S2).

3 categories

Microbiota Metabolism Nutrition

89 phenotypes

Microbiota_OTU001 Microbiota_OTU002 Microbiota_OTU003 Microbiota_OTU004 Microbiota_OTU005 Microbiota_OTU006 Microbiota_OTU007 Microbiota_OTU008 Microbiota_OTU009 Microbiota_OTU010 Microbiota_OTU011 Microbiota_OTU012 Microbiota_OTU013 Microbiota_OTU014 Microbiota_OTU015 Microbiota_OTU016 Microbiota_OTU017 Microbiota_OTU018 Microbiota_OTU019 Microbiota_OTU020 Microbiota_OTU021 Microbiota_OTU022 Microbiota_OTU023 Microbiota_OTU024 Microbiota_OTU025 Microbiota_OTU026 Microbiota_OTU027 Microbiota_OTU028 Microbiota_OTU029 Microbiota_OTU030 Microbiota_OTU031 Microbiota_OTU032 Microbiota_OTU033 Microbiota_OTU034 Microbiota_OTU035 Microbiota_OTU037 Microbiota_OTU040 Microbiota_OTU041 Microbiota_OTU042 Microbiota_OTU044 Microbiota_OTU045 Microbiota_OTU046 Microbiota_OTU047 Microbiota_OTU048 Microbiota_OTU050 Microbiota_OTU051 Microbiota_OTU052 Microbiota_OTU053 Microbiota_OTU056 Microbiota_OTU058 Microbiota_OTU060 Microbiota_OTU063 Microbiota_OTU068 Microbiota_OTU069 Microbiota_OTU073 Microbiota_OTU074 Microbiota_OTU077 Microbiota_OTU081 Microbiota_OTU082 Microbiota_OTU087 Microbiota_OTU090 Microbiota_OTU091 Microbiota_OTU110 Microbiota_OTU115 Microbiota_OTU121 Microbiota_OTU124 Microbiota_OTU127 Microbiota_OTU134 Microbiota_OTU137 Microbiota_OTU154 Microbiota_OTU160 Microbiota_OTU166 Microbiota_OTU170 Microbiota_OTU171 Microbiota_OTU172 Microbiota_OTU173 mn_Glucose mn_Glycogen mn_Protein mn_TAG_Glycerol pc_Acetobacteraceae pc_Comamonadaceae pc_Lactobacillaceae pc_Other pc_Xanthomonadaceae se_Glucose se_Glycogen se_Protein se_TAG_Glycerol

Datasets

Dataset Phenotypes DGRP lines
Summary dataset 89 phenotypes
Microbiota_OTU001 Microbiota_OTU002 Microbiota_OTU003 Microbiota_OTU004 Microbiota_OTU005 Microbiota_OTU006 Microbiota_OTU007 Microbiota_OTU008 Microbiota_OTU009 Microbiota_OTU010 Microbiota_OTU011 Microbiota_OTU012 Microbiota_OTU013 Microbiota_OTU014 Microbiota_OTU015 Microbiota_OTU016 Microbiota_OTU017 Microbiota_OTU018 Microbiota_OTU019 Microbiota_OTU020 Microbiota_OTU021 Microbiota_OTU022 Microbiota_OTU023 Microbiota_OTU024 Microbiota_OTU025 Microbiota_OTU026 Microbiota_OTU027 Microbiota_OTU028 Microbiota_OTU029 Microbiota_OTU030 Microbiota_OTU031 Microbiota_OTU032 Microbiota_OTU033 Microbiota_OTU034 Microbiota_OTU035 Microbiota_OTU037 Microbiota_OTU040 Microbiota_OTU041 Microbiota_OTU042 Microbiota_OTU044 Microbiota_OTU045 Microbiota_OTU046 Microbiota_OTU047 Microbiota_OTU048 Microbiota_OTU050 Microbiota_OTU051 Microbiota_OTU052 Microbiota_OTU053 Microbiota_OTU056 Microbiota_OTU058 Microbiota_OTU060 Microbiota_OTU063 Microbiota_OTU068 Microbiota_OTU069 Microbiota_OTU073 Microbiota_OTU074 Microbiota_OTU077 Microbiota_OTU081 Microbiota_OTU082 Microbiota_OTU087 Microbiota_OTU090 Microbiota_OTU091 Microbiota_OTU110 Microbiota_OTU115 Microbiota_OTU121 Microbiota_OTU124 Microbiota_OTU127 Microbiota_OTU134 Microbiota_OTU137 Microbiota_OTU154 Microbiota_OTU160 Microbiota_OTU166 Microbiota_OTU170 Microbiota_OTU171 Microbiota_OTU172 Microbiota_OTU173 mn_Glucose mn_Glycogen mn_Protein mn_TAG_Glycerol pc_Acetobacteraceae pc_Comamonadaceae pc_Lactobacillaceae pc_Other pc_Xanthomonadaceae se_Glucose se_Glycogen se_Protein se_TAG_Glycerol
109 DGRP lines
DGRP_223
DGRP_237
DGRP_272
DGRP_367
DGRP_393
DGRP_398
DGRP_514
DGRP_554
DGRP_642
DGRP_750
DGRP_771
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