Rohde et al., 2017
Genomic Analysis of Genotype-by-Social Environment Interaction for Drosophila melanogaster Aggressive Behavior
[10.1534/genetics.117.200642][FBrf0236263]

Description

This study investigated the genetic basis of variation in male aggressive behavior for flies reared in a socialized and socially isolated environment. A large proportion of associated genes have previously been associated with aggressive behavior in Drosophila and mice, and have human orthologs that have been associated with neurological disorders, indicating partially shared genetic mechanisms underlying aggression in animal models and human psychiatric disorders.

Comments from curator

Phenotyping data were extracted from Table S1 in the Supplementary data section.

A behavioral arena, the Flydiator arena [sic], was developed to facilitate high-throughput acquisition of aggression data on pairs of individuals; one DGRP and one control fly (CSB).

87 DGRP lines 87 genotyped

DGRP_032 DGRP_038 DGRP_042 DGRP_045 DGRP_059 DGRP_073 DGRP_075 DGRP_085 DGRP_093 DGRP_109 DGRP_136 DGRP_142 DGRP_158 DGRP_176 DGRP_177 DGRP_195 DGRP_208 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_239 DGRP_256 DGRP_280 DGRP_310 DGRP_317 DGRP_320 DGRP_321 DGRP_325 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_358 DGRP_359 DGRP_362 DGRP_365 DGRP_370 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_383 DGRP_386 DGRP_392 DGRP_399 DGRP_406 DGRP_426 DGRP_437 DGRP_505 DGRP_508 DGRP_509 DGRP_517 DGRP_551 DGRP_559 DGRP_563 DGRP_596 DGRP_627 DGRP_630 DGRP_634 DGRP_712 DGRP_730 DGRP_737 DGRP_748 DGRP_765 DGRP_774 DGRP_790 DGRP_801 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_820 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_857 DGRP_884 DGRP_890 DGRP_892 DGRP_897 DGRP_907 DGRP_908 DGRP_911

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	9 phenotypes Aggression_GSEI mn_Aggressi_Isol_ADJ mn_Aggressi_Isolated mn_Aggressi_Soci_ADJ mn_Aggression_Social se_Aggressi_Isolated se_Aggression_Social	87 DGRP lines DGRP_032 DGRP_038 DGRP_042 DGRP_045 DGRP_059 DGRP_073 DGRP_075 DGRP_085 DGRP_093 DGRP_109 DGRP_136 DGRP_142 DGRP_158 DGRP_176 DGRP_177 DGRP_195 DGRP_208 DGRP_223 DGRP_227 DGRP_228 DGRP_229 DGRP_239 DGRP_256 DGRP_280 DGRP_310 DGRP_317 DGRP_320 DGRP_321 DGRP_325 DGRP_332 DGRP_335 DGRP_336 DGRP_338 DGRP_340 DGRP_358 DGRP_359 DGRP_362 DGRP_365 DGRP_370 DGRP_373 DGRP_375 DGRP_377 DGRP_379 DGRP_383 DGRP_386 DGRP_392 DGRP_399 DGRP_406 DGRP_426 DGRP_437 DGRP_505 DGRP_508 DGRP_509 DGRP_517 DGRP_551 DGRP_559 DGRP_563 DGRP_596 DGRP_627 DGRP_630 DGRP_634 DGRP_712 DGRP_730 DGRP_737 DGRP_748 DGRP_765 DGRP_774 DGRP_790 DGRP_801 DGRP_804 DGRP_805 DGRP_808 DGRP_810 DGRP_820 DGRP_837 DGRP_843 DGRP_849 DGRP_850 DGRP_852 DGRP_857 DGRP_884 DGRP_890 DGRP_892 DGRP_897 DGRP_907 DGRP_908 DGRP_911	Download