Srivastav et al., 2017
Paternal Induction of Hybrid Dysgenesis in Drosophila melanogaster Is Weakly Correlated with Both P-Element and hobo Element Dosage
[10.1534/g3.117.040634][FBrf0235441]

Description

Transposable elements (TEs) produce specific deleterious mutations by insertional inactivation, inducing DNA damage and participating in ectopic recombination. These effects are often assumed to be dosage-dependent, with stronger effects occurring in the presence of higher TE copy numbers. The authors tested this assumption by considering the relationship between the copy number of two active DNA transposons, P-element and hobo element, and the incidence of hybrid dysgenesis, a sterility syndrome associated with transposon activity in the germline.

Comments from curator

The phenotyping data is no longer available from the journal's website.

The phenotyping data are a bit redundant/correlated since the authors tested 6 different pipelines to estimate the structural variation of Full Length (FL) and KP structural variations in P-Elements, and two pipelines to estimate the structural variation of Full Length (FL) and CN structural variations in Hobo Elements. All the pipelines are described in Table 1.
In addition, for Hobo Elements, two different annotation datasets (TIDAL and TEMP) were used.

Corrigendum: A correction has been published correcting the mislabelling of Figure 1.

53 DGRP lines 52 genotyped 1 not_genotyped

DGRP_038 DGRP_040 DGRP_042 DGRP_055 DGRP_057 DGRP_075 DGRP_083 DGRP_109 DGRP_142 DGRP_177 DGRP_229 DGRP_235 DGRP_320 DGRP_321 DGRP_370 DGRP_371 DGRP_373 DGRP_377 DGRP_383 DGRP_391 DGRP_392 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_492 DGRP_502 DGRP_508 DGRP_513 DGRP_517 DGRP_531 DGRP_765 DGRP_774 DGRP_790 DGRP_801 DGRP_802 DGRP_805 DGRP_808 DGRP_812 DGRP_822 DGRP_855 DGRP_882 DGRP_887 DGRP_892 DGRP_894 DGRP_907 DGRP_908

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	35 phenotypes CN_Hobo_TEMP CN_Hobo_TEMP_W CN_Hobo_TIDAL CN_Hobo_TIDAL_W Hobo_Relative_Cov pc_CN_Hobo_HC pc_CN_Hobo_HS pc_Deletion_PElem_GC pc_Deletion_PElem_GS pc_Deletion_PElem_HC pc_Deletion_PElem_HS pc_Deletion_PElem_SC pc_Deletion_PElem_SS pc_FLCN_Hobo_HC pc_FLCN_Hobo_HS pc_FL_Hobo_HC pc_FL_Hobo_HS pc_FL_PElem_GC pc_FL_PElem_GS pc_FL_PElem_HC pc_FL_PElem_HS pc_FL_PElem_SC pc_FL_PElem_SS pc_FPKP_PElem_GC pc_FPKP_PElem_GS pc_FPKP_PElem_HC pc_FPKP_PElem_HS pc_FPKP_PElem_SC pc_FPKP_PElem_SS pc_KP_PElem_GC pc_KP_PElem_GS pc_KP_PElem_HC pc_KP_PElem_HS pc_KP_PElem_SC pc_KP_PElem_SS	52 DGRP lines DGRP_038 DGRP_040 DGRP_042 DGRP_055 DGRP_057 DGRP_075 DGRP_083 DGRP_109 DGRP_142 DGRP_177 DGRP_229 DGRP_235 DGRP_320 DGRP_321 DGRP_370 DGRP_371 DGRP_373 DGRP_377 DGRP_383 DGRP_391 DGRP_392 DGRP_405 DGRP_406 DGRP_409 DGRP_426 DGRP_437 DGRP_439 DGRP_440 DGRP_441 DGRP_443 DGRP_461 DGRP_492 DGRP_502 DGRP_508 DGRP_513 DGRP_517 DGRP_531 DGRP_765 DGRP_774 DGRP_790 DGRP_801 DGRP_802 DGRP_805 DGRP_808 DGRP_812 DGRP_822 DGRP_882 DGRP_887 DGRP_892 DGRP_894 DGRP_907 DGRP_908	Download
Raw dataset #1	1 phenotypes Ovarian_Atrophy	33 DGRP lines DGRP_038 DGRP_040 DGRP_042 DGRP_075 DGRP_083 DGRP_109 DGRP_142 DGRP_177 DGRP_229 DGRP_235 DGRP_320 DGRP_370 DGRP_371 DGRP_373 DGRP_377 DGRP_383 DGRP_391 DGRP_405 DGRP_409 DGRP_439 DGRP_440 DGRP_443 DGRP_461 DGRP_508 DGRP_513 DGRP_517 DGRP_765 DGRP_801 DGRP_802 DGRP_805 DGRP_808 DGRP_855 DGRP_907	Download