Study

Curated
Srivastav et al., 2017
Paternal Induction of Hybrid Dysgenesis in Drosophila melanogaster Is Weakly Correlated with Both P-Element and hobo Element Dosage
[10.1534/g3.117.040634][FBrf0235441]

Description

Transposable elements (TEs) produce specific deleterious mutations by insertional inactivation, inducing DNA damage and participating in ectopic recombination. These effects are often assumed to be dosage-dependent, with stronger effects occurring in the presence of higher TE copy numbers. The authors tested this assumption by considering the relationship between the copy number of two active DNA transposons, P-element and hobo element, and the incidence of hybrid dysgenesis, a sterility syndrome associated with transposon activity in the germline.

Comments from curator

The phenotyping data is no longer available from the journal's website.

The phenotyping data are a bit redundant/correlated since the authors tested 6 different pipelines to estimate the structural variation of Full Length (FL) and KP structural variations in P-Elements, and two pipelines to estimate the structural variation of Full Length (FL) and CN structural variations in Hobo Elements. All the pipelines are described in Table 1.
In addition, for Hobo Elements, two different annotation datasets (TIDAL and TEMP) were used.

Corrigendum: A correction has been published correcting the mislabelling of Figure 1.
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