Hope et al., 2019
The Drosophila Gene Sulfateless Modulates Autism-Like Behaviors
[10.3389/fgene.2019.00574][FBrf0242954]

Description

This study investigates autism spectrum disorder (ASD) risk, through three phenotypes with analogous behavior domains: impaired social communication, social reciprocity and repetitive behaviors or restricted interests. They studied ASD gene orthologs (neurexin 4 and neuroligin 2), an intellectual disability (ID) gene homolog (kirre), and a gene encoding a heparan sulfate (HS) modifying enzyme called sulfateless (sfl). SNPs in sfl were associated with all three ASD-like behaviors.

Comments from curator

Mean phenotyping data were downloaded from Supplemental Data 1 found in the Supplementary material section. Of note, we rather used the raw phenotyping data available in Supplemental Data 4.

46 DGRP lines 46 genotyped

DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_774 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	3 phenotypes Ave_Mating_Latency Ave_Social_Space Ave_Time_Grooming	45 DGRP lines DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879	Download
Raw dataset #1	3 phenotypes MatingLatency SocialSpace TimeGrooming	46 DGRP lines DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_774 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879	Download