Hope et al., 2019
The Drosophila Gene Sulfateless Modulates Autism-Like Behaviors
[10.3389/fgene.2019.00574][FBrf0242954]

Description

This study measured three autism spectrum disorder (ASD)-like behaviors in males and females of 46 DGRP lines: social communication (mating latency), repetitive behavior (time spent grooming) and social reciprocity (social spacing in groups of 25 flies). SNPs in sulfateless (sfl) were associated with all three behaviors.

Comments from curator

Phenotyping data comes from Data Sheet 1 in the Supplementary material section:
- Supplemental_Data_4.xlsx: raw values per trial (one fly or one pair for mating latency and grooming, one group of 25 flies for social spacing), used for the raw dataset.
- Supplemental_Data_1.xlsx: means per DGRP line and sex, used by the authors for their GWAS, used for the summary dataset (mn_*Auth phenotypes).

For mating latency, the sex is the one of the tested DGRP fly. Pairs that did not mate during the 30 min observation were scored 1800 s by the authors: these values were set to NA in the raw dataset, consistent with the authors' means, which exclude them.

Of note, for some lines the authors' means were computed on only part of the trials (often only the first one), so they cannot all be recomputed from the raw data: the means computed by DGRPool from the raw dataset differ from the authors' means for 38 of the 244 line/sex combinations (20 for mating latency, 12 for grooming, 6 for social spacing). This is why both datasets are provided.

The paper mentions 40 DGRP lines, but the supplementary data contains 46 lines (45 in Supplemental Data 1).

46 DGRP lines 46 genotyped

DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_774 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	3 phenotypes mn_MatingLatencyAuth mn_SocialSpaceAuth mn_TimeGroomingAuth	45 DGRP lines DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879	Download
Raw dataset #1	3 phenotypes MatingLatency SocialSpace TimeGrooming	46 DGRP lines DGRP_028 DGRP_038 DGRP_042 DGRP_045 DGRP_057 DGRP_059 DGRP_083 DGRP_085 DGRP_101 DGRP_105 DGRP_109 DGRP_136 DGRP_158 DGRP_181 DGRP_189 DGRP_195 DGRP_208 DGRP_217 DGRP_228 DGRP_229 DGRP_235 DGRP_237 DGRP_239 DGRP_287 DGRP_310 DGRP_315 DGRP_360 DGRP_365 DGRP_370 DGRP_373 DGRP_379 DGRP_383 DGRP_399 DGRP_437 DGRP_443 DGRP_555 DGRP_563 DGRP_595 DGRP_707 DGRP_732 DGRP_774 DGRP_786 DGRP_821 DGRP_859 DGRP_861 DGRP_879	Download