Zwarts et al., 2015
The genetic basis of natural variation in mushroom body size in Drosophila melanogaster
[10.1038/ncomms10115][FBrf0230412]

Description

The mammalian cerebral cortex and the insect mushroom bodies (MBs) are key higher-order brain centers for the integration and processing of sensory information. The size of the cerebral cortex and the MBs has been regarded as a proxy for cognitive ability and behavioral plasticity. Here the authors mapped variants affecting natural variation in mushroom body morphology and identified 139 genes and 39 transcription factors with effects on development and adult plasticity. They also showed correlations between morphology and aggression, sleep, and lifespan.

Comments from curator

Phenotyping data can be downloaded from the Supplementary Data 1 file found in the Supplementary information section.

The authors also compared their phenotypes, with phenotypes from other studies: aggressive behaviour, copulation latency, fitness, startle response, ethanol resistance, starvation resistance, lifespan, chill coma recovery and sleep traits (Harbison et al., 2013) (Ayroles et al., 2009) (Morozova et al., 2009)

Of note: We added a "Normal" phenotype to complete the ratio of abnormal traits, for each DGRP.

40 DGRP lines 1 not_genotyped 39 genotyped

DGRP_208 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_313 DGRP_315 DGRP_324 DGRP_335 DGRP_357 DGRP_358 DGRP_360 DGRP_362 DGRP_365 DGRP_375 DGRP_379 DGRP_380 DGRP_391 DGRP_399 DGRP_427 DGRP_437 DGRP_486 DGRP_514 DGRP_517 DGRP_555 DGRP_639 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_730 DGRP_732 DGRP_765 DGRP_774 DGRP_786 DGRP_799 DGRP_820 DGRP_852 DGRP_859

Datasets

Dataset	Phenotypes	DGRP lines
Summary dataset	11 phenotypes pc_MB_Alpha_Abnormal pc_MB_Alpha_Missing pc_MB_Alpha_Normal pc_MB_Alpha_Short pc_MB_Alpha_Thin pc_MB_Beta_Abnormal pc_MB_Beta_Fusion pc_MB_Beta_Missing pc_MB_Beta_Normal pc_MB_Beta_Short pc_MB_Beta_Thin	40 DGRP lines DGRP_208 DGRP_301 DGRP_303 DGRP_304 DGRP_306 DGRP_307 DGRP_313 DGRP_315 DGRP_324 DGRP_335 DGRP_357 DGRP_358 DGRP_360 DGRP_362 DGRP_365 DGRP_375 DGRP_379 DGRP_380 DGRP_391 DGRP_399 DGRP_427 DGRP_437 DGRP_486 DGRP_514 DGRP_517 DGRP_555 DGRP_639 DGRP_705 DGRP_707 DGRP_712 DGRP_714 DGRP_730 DGRP_732 DGRP_765 DGRP_774 DGRP_786 DGRP_799 DGRP_820 DGRP_852 DGRP_859	Download