Zhao et al., 2022
The metabolome as a biomarker of aging in Drosophila melanogaster
[10.1111/acel.13548][FBrf0252669]

Description

This study followed adult cohorts of 20 DGRP strains chosen to represent the breadth of lifespan variation. They phenotyped lifespan, baseline mortality, and rate of aging and associated these parameters with age-specific functional traits including fecundity, climbing activity, and age-specific targeted metabolomic profiles. They show that activity levels and metabolome-wide profiles are strongly associated with age, that numerous individual metabolites show a strong association with lifespan, and that the metabolome provides a biological clock that predicts not only sample age but also future mortality rates and lifespan.

Comments from curator

20 DGRP lines 20 genotyped

DGRP_026 DGRP_038 DGRP_093 DGRP_101 DGRP_136 DGRP_138 DGRP_208 DGRP_228 DGRP_320 DGRP_355 DGRP_362 DGRP_385 DGRP_405 DGRP_426 DGRP_440 DGRP_441 DGRP_443 DGRP_502 DGRP_703 DGRP_796

Datasets

Dataset	Phenotypes	DGRP lines
Raw dataset #1	15 phenotypes Block Climb_Decline Climb_Week3 Climb_Week4 Climb_Week5 Climb_Week6 LogMAlpha LogMiu45 LogMiu60 MBeta Makeham MeanLS MedianLS RepOutput_Day08 RepOutput_Day12	20 DGRP lines DGRP_026 DGRP_038 DGRP_093 DGRP_101 DGRP_136 DGRP_138 DGRP_208 DGRP_228 DGRP_320 DGRP_355 DGRP_362 DGRP_385 DGRP_405 DGRP_426 DGRP_440 DGRP_441 DGRP_443 DGRP_502 DGRP_703 DGRP_796	Download