Study

Under curation
Zhao et al., 2022
The metabolome as a biomarker of aging in Drosophila melanogaster
[10.1111/acel.13548][FBrf0252669]

Description

This study followed adult cohorts of 20 DGRP strains chosen to represent the breadth of lifespan variation. They phenotyped lifespan, baseline mortality, and rate of aging and associated these parameters with age-specific functional traits including fecundity, climbing activity, and age-specific targeted metabolomic profiles. They show that activity levels and metabolome-wide profiles are strongly associated with age, that numerous individual metabolites show a strong association with lifespan, and that the metabolome provides a biological clock that predicts not only sample age but also future mortality rates and lifespan.

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