©2022 Deplancke lab, EPFL, 1015 Lausanne
Ageing is defined by the decline of physiological functions in various organs and tissues leading to an increased probability of death. Some individuals delay, escape or survive much of this age-related decline. Most of the known genetic associations only account for small percentages of the variance in lifespan. Therefore, ageing is probably a highly polygenic trait. Longitudinal data of age-related traits can be used in association studies to test for polymorphisms that predict how an individual will change over time.
| Reference | Status | Publication date | Submitted by | |
|---|---|---|---|---|
| Arya et al., 2010 Natural Variation, Functional Pleiotropy and Transcriptional Contexts of Odorant Binding Protein Genes in Drosophila melanogaster [10.1534/genetics.110.123166][FBrf0212597] |
Curated |
2010-11-30 | Roel Bevers | |
| Jordan et al., 2012 Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster [10.1371/journal.pone.0038722][FBrf0218606] |
Curated |
2012-06-07 | Roel Bevers | |
| Durham et al., 2014 Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits [10.1038/ncomms5338][FBrf0225589] |
Curated |
2014-08-31 | Roel Bevers | |
| Carbone et al., 2016 Genetic architecture of natural variation in visual senescence in Drosophila [10.1073/pnas.1613833113][FBrf0233864] |
Curated |
2016-10-24 | Roel Bevers | |
| Hoffman et al., 2021 Sex, mating and repeatability of Drosophila melanogaster longevity [10.1098/rsos.210273][FBrf0250359] |
Under curation |
2021-07-31 | romain.rochepeau | |
| Schiffman et al., 2020 Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury† [10.1016/j.bja.2020.03.029][FBrf0245944] |
Under curation |
2020-06-30 | romain.rochepeau | |
| Ivanov et al., 2015 Longevity GWAS Using the Drosophila Genetic Reference Panel [10.1093/gerona/glv047][FBrf0230043] |
Curated |
2015-11-30 | Roel Bevers | |
| Zhao et al., 2022 The metabolome as a biomarker of aging in Drosophila melanogaster [10.1111/acel.13548][FBrf0252669] |
Under curation |
2022-01-31 | romain.rochepeau | |
| Huang et al., 2020 Context-dependent genetic architecture of Drosophila life span [10.1371/journal.pbio.3000645][FBrf0245198] |
Curated |
2020-03-04 | Roel Bevers |