©2022-2026 Deplancke lab, EPFL, 1015 Lausanne
Rate of formation of full type-2 resistance alleles in the early embryo among the daughters that inherited the drive: white-eyed dsRed daughters / all dsRed daughters, one value per vial. Measured with a second CRISPR homing drive, with otherwise identical components, targeting the X-linked white gene instead of yellow (Data S3, 3 DGRP lines x 5 vials, Figure S3). Measured on the F1 drive/wild-type heterozygous daughters of virgin DGRP females crossed to males carrying the drive (nanos-Cas9, 3xP3-dsRed, w1118 background), by scoring the progeny of those F1 flies; the value is assigned to the DGRP line. [Proportion / Ratio]