DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=7.230e^-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test

Covariate	p-value	Significance
wolba	0.00538
In_3R_P	0.03001

Kruskal-Wallis test

Covariate	χ²	p-value	Significance
wolba	9.1756	0.0025
In_3R_P	7.3251	0.0257

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

1560 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

Show entries

Search:

Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
2L	7624844	2L_7624844_INS [dm3] 2L_7624844_INS [dm6]	T	TCTCGCTGCTCCTCGCTGCA...	1.006e^-6	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_Kr mE1_TFBS_sens
2L	3235687	2L_3235687_SNP [dm3] 2L_3235687_SNP [dm6]	A	G	1.628e^-6	0.759	INTERGENIC
2R	17882103	2R_17882103_SNP [dm3] 2R_21994598_SNP [dm6]	T	G	1.865e^-6	0.759	INTRON CG34370
3L	12634892	3L_12634892_DEL [dm3] 3L_12641792_DEL [dm6]	AA	A	2.395e^-6	0.759	INTRON CR32111	TF binding site BDTNP1_TFBS_twi
2L	10826449	2L_10826449_SNP [dm3] 2L_10826449_SNP [dm6]	A	G	2.488e^-6	0.759	INTRON Nos
2L	3236134	2L_3236134_SNP [dm3] 2L_3236134_SNP [dm6]	G	A	2.878e^-6	0.759	INTERGENIC
3L	11116612	3L_11116612_SNP [dm3] 3L_11123512_SNP [dm6]	C	A	4.661e^-6	0.759	UPSTREAM Ufd1-like INTRON CG42575	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi mE1_TFBS_bab1 mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Trl
2L	7624838	2L_7624838_MNP [dm3] 2L_7624838_MNP [dm6]	AGT	GCA	5.616e^-6	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_Kr mE1_TFBS_sens
2L	7624383	2L_7624383_SNP [dm3] 2L_7624383_SNP [dm6]	G	C	5.764e^-6	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Kr
2L	3235567	2L_3235567_SNP [dm3] 2L_3235567_SNP [dm6]	A	C	6.258e^-6	0.759	INTERGENIC
X	5701631	X_5701631_SNP [dm3] X_5807598_SNP [dm6]	G	C	6.495e^-6	0.759	INTERGENIC
X	7056349	X_7056349_SNP [dm3] X_7162316_SNP [dm6]	T	A	6.730e^-6	0.759	INTRON CG9650	silencer mE1_HDAC_PRE TF binding site BDTNP1_TFBS_dl mE1_TFBS_bab1 mE1_TFBS_HSA
X	7999255	X_7999255_SNP [dm3] X_8105222_SNP [dm6]	T	C	6.927e^-6	0.759	INTRON Gclc	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_inv
2R	17881936	2R_17881936_DEL [dm3] 2R_21994431_DEL [dm6]	TTTATGC	A	7.802e^-6	0.759	INTRON CG34370
2R	17881946	2R_17881946_SNP [dm3] 2R_21994441_SNP [dm6]	T	A	7.802e^-6	0.759	INTRON CG34370
X	5094515	X_5094515_SNP [dm3] X_5200482_SNP [dm6]	C	A	8.343e^-6	0.759	INTRON rg & 1 other
2R	17881997	2R_17881997_SNP [dm3] 2R_21994492_SNP [dm6]	A	T	9.115e^-6	0.759	INTRON CG34370
2L	795482	2L_795482_SNP [dm3] 2L_795482_SNP [dm6]	T	C	9.902e^-6	0.759	INTERGENIC
X	3307656	X_3307656_SNP [dm3] X_3413623_SNP [dm6]	T	C	1.017e^-5	0.759	INTRON CR44999 & 1 other
X	3307677	X_3307677_SNP [dm3] X_3413644_SNP [dm6]	A	C	1.017e^-5	0.759	INTRON CR44999 & 1 other
2L	10826429	2L_10826429_SNP [dm3] 2L_10826429_SNP [dm6]	T	C	1.132e^-5	0.759	INTRON Nos
2L	6099239	2L_6099239_SNP [dm3] 2L_6099239_SNP [dm6]	C	T	1.177e^-5	0.759	UPSTREAM CG9175 INTERGENIC	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Ubx
X	12849231	X_12849231_INS [dm3] X_12955198_INS [dm6]	A	AGAAACACA	1.184e^-5	0.759	INTRON hec
3R	14971816	3R_14971816_SNP [dm3] 3R_19146094_SNP [dm6]	G	C	1.191e^-5	0.759	INTRON Ppcs
2L	3234118	2L_3234118_SNP [dm3] 2L_3234118_SNP [dm6]	A	G	1.199e^-5	0.759	INTERGENIC
2L	7622372	2L_7622372_INS [dm3] 2L_7622372_INS [dm6]	T	TT	1.287e^-5	0.759	INTERGENIC	TF binding site mE1_TFBS_cad
X	995120	X_995120_SNP [dm3] X_1101087_SNP [dm6]	G	T	1.320e^-5	0.759	INTRON CG3655
2R	11811658	2R_11811658_SNP [dm3] 2R_15924153_SNP [dm6]	G	A	1.367e^-5	0.759	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad
3L	11119712	3L_11119712_SNP [dm3] 3L_11126612_SNP [dm6]	T	A	1.385e^-5	0.759	INTRON CG42575	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_bab1 mE1_TFBS_cad mE1_TFBS_HSA
2R	9176312	2R_9176312_SNP [dm3] 2R_13288807_SNP [dm6]	T	G	1.385e^-5	0.759	INTRON Dh31-R
2R	11811761	2R_11811761_SNP [dm3] 2R_15924256_SNP [dm6]	T	C	1.421e^-5	0.759	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad
2L	7624370	2L_7624370_SNP [dm3] 2L_7624370_SNP [dm6]	T	A	1.422e^-5	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Kr
2R	17815177	2R_17815177_SNP [dm3] 2R_21927672_SNP [dm6]	A	G	1.444e^-5	0.759	INTRON Fili
3R	14971746	3R_14971746_SNP [dm3] 3R_19146024_SNP [dm6]	A	C	1.490e^-5	0.759	INTRON Ppcs
2R	17881794	2R_17881794_SNP [dm3] 2R_21994289_SNP [dm6]	A	G	1.558e^-5	0.759	INTRON CG34370
2R	17891813	2R_17891813_SNP [dm3] 2R_22004308_SNP [dm6]	G	T	1.570e^-5	0.759	INTRON CG34370
2L	7624399	2L_7624399_DEL [dm3] 2L_7624399_DEL [dm6]	ATATTCTTTCGAGTGAAT...	A	1.610e^-5	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Kr
2L	7624424	2L_7624424_SNP [dm3] 2L_7624424_SNP [dm6]	G	A	1.610e^-5	0.759	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Kr
2R	11806594	2R_11806594_SNP [dm3] 2R_15919089_SNP [dm6]	T	C	1.643e^-5	0.759	INTRON sli	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
3L	11111333	3L_11111333_SNP [dm3] 3L_11118233_SNP [dm6]	T	G	1.650e^-5	0.759	INTRON fd68A	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_Trl
2L	10884654	2L_10884654_SNP [dm3] 2L_10884654_SNP [dm6]	C	G	1.659e^-5	0.759	INTERGENIC
3L	18548447	3L_18548447_SNP [dm3] 3L_18555347_SNP [dm6]	A	T	1.702e^-5	0.76	INTERGENIC
2L	7624421	2L_7624421_SNP [dm3] 2L_7624421_SNP [dm6]	T	A	1.857e^-5	0.796	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Kr
2R	17561868	2R_17561868_SNP [dm3] 2R_21674363_SNP [dm6]	A	C	1.868e^-5	0.796	UPSTREAM CG30263 INTERGENIC
3L	11113494	3L_11113494_SNP [dm3] 3L_11120394_SNP [dm6]	G	A	2.068e^-5	0.796	UTR_5_PRIME fd68A UPSTREAM fd68A & 1 other INTRON fd68A	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Trl mE1_TFBS_zfh1
2L	2388349	2L_2388349_SNP [dm3] 2L_2388349_SNP [dm6]	T	C	2.069e^-5	0.796	INTERGENIC	TF binding site BDTNP1_TFBS_twi
2L	3235770	2L_3235770_SNP [dm3] 2L_3235770_SNP [dm6]	T	C	2.118e^-5	0.796	INTERGENIC
2R	15029928	2R_15029928_SNP [dm3] 2R_19142423_SNP [dm6]	T	C	2.128e^-5	0.796	INTRON ena	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_D mE1_TFBS_HSA mE1_TFBS_Trl
2L	7624752	2L_7624752_SNP [dm3] 2L_7624752_SNP [dm6]	G	A	2.179e^-5	0.796	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_Kr mE1_TFBS_sens
2L	16816621	2L_16816621_SNP [dm3] 2L_16816621_SNP [dm6]	G	C	2.238e^-5	0.796	UPSTREAM mdy DOWNSTREAM CG13272 INTRON CG13280	TF binding site BDTNP1_TFBS_dl mE1_TFBS_bab1 mE1_TFBS_HSA mE1_TFBS_Kr mE1_TFBS_zfh1
3L	18553467	3L_18553467_SNP [dm3] 3L_18560367_SNP [dm6]	A	G	2.292e^-5	0.796	UTR_5_PRIME AstC-R1	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	14535910	3R_14535910_SNP [dm3] 3R_18710188_SNP [dm6]	T	G	2.308e^-5	0.796	INTRON VAChT & 1 other
2R	11813093	2R_11813093_SNP [dm3] 2R_15925588_SNP [dm6]	T	A	2.386e^-5	0.796	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
3L	17578034	3L_17578034_SNP [dm3] 3L_17584934_SNP [dm6]	G	A	2.419e^-5	0.796	INTRON Eip74EF
X	15536343	X_15536343_SNP [dm3] X_15642310_SNP [dm6]	G	A	2.459e^-5	0.796	UPSTREAM CR44893 INTERGENIC
3L	8095862	3L_8095862_SNP [dm3] 3L_8102762_SNP [dm6]	G	T	2.504e^-5	0.796	INTRON Ect4	TF binding site mE1_TFBS_cad
3L	8095865	3L_8095865_SNP [dm3] 3L_8102765_SNP [dm6]	T	A	2.504e^-5	0.796	INTRON Ect4	TF binding site mE1_TFBS_cad
3L	8095872	3L_8095872_SNP [dm3] 3L_8102772_SNP [dm6]	T	A	2.504e^-5	0.796	INTRON Ect4	TF binding site mE1_TFBS_cad
3L	8095903	3L_8095903_SNP [dm3] 3L_8102803_SNP [dm6]	C	T	2.504e^-5	0.796	INTRON Ect4	TF binding site mE1_TFBS_cad
2L	786885	2L_786885_SNP [dm3] 2L_786885_SNP [dm6]	G	A	2.647e^-5	0.827	SYNONYMOUS_CODING Pkg21D UTR_3_PRIME CG3544 DOWNSTREAM CG3544	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_sens
2L	3233453	2L_3233453_SNP [dm3] 2L_3233453_SNP [dm6]	C	A	2.763e^-5	0.829	INTERGENIC
2R	18911411	2R_18911411_SNP [dm3] 2R_23023888_SNP [dm6]	T	C	2.788e^-5	0.829	INTRON twi & 1 other
2R	11811464	2R_11811464_SNP [dm3] 2R_15923959_SNP [dm6]	A	G	2.798e^-5	0.829	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad
2L	4266251	2L_4266251_INS [dm3] 2L_4266251_INS [dm6]	G	GG	2.830e^-5	0.829	INTERGENIC
3R	14971748	3R_14971748_SNP [dm3] 3R_19146026_SNP [dm6]	T	C	2.910e^-5	0.839	INTRON Ppcs
2L	7621233	2L_7621233_SNP [dm3] 2L_7621233_SNP [dm6]	A	C	3.057e^-5	0.868	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	530819	3L_530819_SNP [dm3] 3L_530819_SNP [dm6]	T	C	3.231e^-5	0.875	INTRON klar
3L	18518898	3L_18518898_SNP [dm3] 3L_18525798_SNP [dm6]	T	A	3.238e^-5	0.875	INTERGENIC	TF binding site mE1_TFBS_run
2L	7623436	2L_7623436_SNP [dm3] 2L_7623436_SNP [dm6]	T	A	3.260e^-5	0.875	INTERGENIC	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
X	5467731	X_5467731_SNP [dm3] X_5573698_SNP [dm6]	A	G	3.326e^-5	0.875	INTERGENIC
3L	8672398	3L_8672398_SNP [dm3] 3L_8679298_SNP [dm6]	C	T	3.371e^-5	0.875	DOWNSTREAM h INTERGENIC	regulatory region REDfly_CRMs
2R	17891814	2R_17891814_SNP [dm3] 2R_22004309_SNP [dm6]	C	T	3.401e^-5	0.875	INTRON CG34370
3L	18553427	3L_18553427_SNP [dm3] 3L_18560327_SNP [dm6]	C	T	3.406e^-5	0.875	UTR_5_PRIME AstC-R1	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	17554351	2R_17554351_SNP [dm3] 2R_21666846_SNP [dm6]	A	G	3.482e^-5	0.877	UTR_5_PRIME CG42365 DOWNSTREAM CG42362 & 6 others	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2L	12816628	2L_12816628_SNP [dm3] 2L_12816628_SNP [dm6]	A	G	3.509e^-5	0.877	DOWNSTREAM kek1 INTERGENIC
3L	2850850	3L_2850850_SNP [dm3] 3L_2850850_SNP [dm6]	T	A	3.614e^-5	0.879	INTRON CG43444	TF binding site mE1_TFBS_cad
2R	11813027	2R_11813027_SNP [dm3] 2R_15925522_SNP [dm6]	A	G	3.638e^-5	0.879	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
X	19050983	X_19050983_SNP [dm3] X_19156950_SNP [dm6]	C	G	3.658e^-5	0.879	INTRON RhoGAP18B	TF binding site mE1_TFBS_zfh1
2L	830888	2L_830888_SNP [dm3] 2L_830888_SNP [dm6]	G	A	3.710e^-5	0.881	SYNONYMOUS_CODING dock	TF binding site mE1_TFBS_cad
2R	17878675	2R_17878675_SNP [dm3] 2R_21991170_SNP [dm6]	C	T	3.848e^-5	0.902	INTRON CG34370
2R	19247692	2R_19247692_SNP [dm3] 2R_23360169_SNP [dm6]	T	C	3.991e^-5	0.912	SYNONYMOUS_CODING CG34424 DOWNSTREAM vir & 1 other	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo
2L	16819474	2L_16819474_SNP [dm3] 2L_16819474_SNP [dm6]	A	C	4.005e^-5	0.912	INTRON CG13280 & 1 other	TF binding site mE1_TFBS_cnc
2L	9146901	2L_9146901_SNP [dm3] 2L_9146901_SNP [dm6]	G	A	4.043e^-5	0.912	INTRON CG32982	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Mad BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_shn BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
3L	13267905	3L_13267905_SNP [dm3] 3L_13274805_SNP [dm6]	G	A	4.159e^-5	0.912	INTRON caps	TF binding site mE1_TFBS_chinmo mE1_TFBS_inv
2L	10464115	2L_10464115_SNP [dm3] 2L_10464115_SNP [dm6]	C	T	4.194e^-5	0.912	SYNONYMOUS_CODING RluA-1 UTR_3_PRIME RluA-1
X	9235757	X_9235757_SNP [dm3] X_9341724_SNP [dm6]	G	T	4.212e^-5	0.912	INTRON CG34449
2R	3693195	2R_3693195_INS [dm3] 2R_7805690_INS [dm6]	C	CC	4.290e^-5	0.912	UPSTREAM sax & 1 other INTRON Nop17l	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_Trl
2L	7626997	2L_7626997_SNP [dm3] 2L_7626997_SNP [dm6]	A	T	4.294e^-5	0.912	INTERGENIC
2R	17881879	2R_17881879_SNP [dm3] 2R_21994374_SNP [dm6]	T	C	4.402e^-5	0.912	INTRON CG34370
2R	17878704	2R_17878704_SNP [dm3] 2R_21991199_SNP [dm6]	G	A	4.439e^-5	0.912	INTRON CG34370
2R	10667238	2R_10667238_SNP [dm3] 2R_14779733_SNP [dm6]	G	A	4.499e^-5	0.912	INTRON kn	TF binding site BDTNP1_TFBS_z
X	13060061	X_13060061_SNP [dm3] X_13166028_SNP [dm6]	G	A	4.546e^-5	0.912	INTRON CG34411
2L	9673711	2L_9673711_INS [dm3] 2L_9673711_INS [dm6]	G	GGA	4.618e^-5	0.912	INTERGENIC
3L	18534696	3L_18534696_SNP [dm3] 3L_18541596_SNP [dm6]	T	C	4.792e^-5	0.912	INTERGENIC
2R	11813141	2R_11813141_SNP [dm3] 2R_15925636_SNP [dm6]	A	G	4.866e^-5	0.912	SYNONYMOUS_CODING bdg	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
2L	13716126	2L_13716126_SNP [dm3] 2L_13716126_SNP [dm6]	A	G	4.956e^-5	0.912	INTRON CG31814
3L	19016289	3L_19016289_SNP [dm3] 3L_19023189_SNP [dm6]	G	T	4.961e^-5	0.912	INTRON nkd	TF binding site BDTNP1_TFBS_da mE1_TFBS_cnc mE1_TFBS_HSA
3R	20614794	3R_20614794_SNP [dm3] 3R_24789072_SNP [dm6]	G	A	4.971e^-5	0.912	SYNONYMOUS_CODING CG13634 INTRON Ets96B	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
3R	24263324	3R_24263324_SNP [dm3] 3R_28437602_SNP [dm6]	T	G	4.993e^-5	0.912	INTRON beat-VI
2L	7044111	2L_7044111_SNP [dm3] 2L_7044111_SNP [dm6]	A	C	5.085e^-5	0.912	INTRON milt	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_eve mE1_TFBS_HSA

Showing 1 to 100 of 1,000 entries

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GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=6.128e^-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test

Covariate	p-value	Significance
wolba	0.004331
In_3R_P	0.010503

Kruskal-Wallis test

Covariate	χ²	p-value	Significance
wolba	9.5568	0.002
In_3R_P	8.955	0.0114

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

1474 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
2L	795482	2L_795482_SNP [dm3] 2L_795482_SNP [dm6]	T	C	2.927e^-6	1	INTERGENIC
3L	6314485	3L_6314485_SNP [dm3] 3L_6321385_SNP [dm6]	T	C	3.870e^-6	1	SYNONYMOUS_CODING Or65a
3R	25692153	3R_25692153_SNP [dm3] 3R_29866431_SNP [dm6]	G	T	4.213e^-6	1	UPSTREAM Zip99C INTRON Zip99C
3R	25638254	3R_25638254_SNP [dm3] 3R_29812532_SNP [dm6]	A	G	4.741e^-6	1	INTRON ca	TF binding site mE1_TFBS_chinmo
2R	17881794	2R_17881794_SNP [dm3] 2R_21994289_SNP [dm6]	A	G	5.170e^-6	1	INTRON CG34370
X	8062946	X_8062946_SNP [dm3] X_8168913_SNP [dm6]	T	G	6.538e^-6	1	INTRON CG2278	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
X	7056349	X_7056349_SNP [dm3] X_7162316_SNP [dm6]	T	A	7.152e^-6	1	INTRON CG9650	silencer mE1_HDAC_PRE TF binding site BDTNP1_TFBS_dl mE1_TFBS_bab1 mE1_TFBS_HSA
2L	19963585	2L_19963585_SNP [dm3] 2L_19963585_SNP [dm6]	G	A	7.274e^-6	1	NON_SYNONYMOUS_CODING CG16772 UPSTREAM CG10680 DOWNSTREAM CR45701
2L	10826449	2L_10826449_SNP [dm3] 2L_10826449_SNP [dm6]	A	G	7.911e^-6	1	INTRON Nos
3L	16463387	3L_16463387_SNP [dm3] 3L_16470287_SNP [dm6]	G	T	1.255e^-5	1	DOWNSTREAM aos INTRON CG33158
2R	17881936	2R_17881936_DEL [dm3] 2R_21994431_DEL [dm6]	TTTATGC	A	1.308e^-5	1	INTRON CG34370
2R	17881946	2R_17881946_SNP [dm3] 2R_21994441_SNP [dm6]	T	A	1.308e^-5	1	INTRON CG34370
3L	7865775	3L_7865775_SNP [dm3] 3L_7872675_SNP [dm6]	T	A	1.313e^-5	1	INTRON CG32365	TF binding site mE1_TFBS_kn
X	9689591	X_9689591_SNP [dm3] X_9795558_SNP [dm6]	T	G	1.341e^-5	1	INTRON CG32698
X	8062932	X_8062932_SNP [dm3] X_8168899_SNP [dm6]	C	T	1.344e^-5	1	INTRON CG2278	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
2R	17881997	2R_17881997_SNP [dm3] 2R_21994492_SNP [dm6]	A	T	1.383e^-5	1	INTRON CG34370
3L	10454573	3L_10454573_SNP [dm3] 3L_10461473_SNP [dm6]	C	T	1.549e^-5	1	NON_SYNONYMOUS_CODING Gem3
X	16877122	X_16877122_DEL [dm3] X_16983089_DEL [dm6]	GACAAAG	G	1.768e^-5	1	INTRON CG45002
2R	17597884	2R_17597884_SNP [dm3] 2R_21710379_SNP [dm6]	T	C	1.839e^-5	1	SYNONYMOUS_CODING CG30403 UPSTREAM CR44749 INTRON HmgD	TF binding site BDTNP1_TFBS_dl
2L	8231590	2L_8231590_SNP [dm3] 2L_8231590_SNP [dm6]	A	G	2.128e^-5	1	UPSTREAM Pvr INTRON Pvr
2L	3301037	2L_3301037_SNP [dm3] 2L_3301037_SNP [dm6]	A	T	2.248e^-5	1	INTRON CG9663
2R	14992596	2R_14992596_SNP [dm3] 2R_19105091_SNP [dm6]	C	T	2.277e^-5	1	INTRON 5-HT1A
X	16876533	X_16876533_SNP [dm3] X_16982500_SNP [dm6]	C	T	2.318e^-5	1	INTRON CG45002
3L	13916975	3L_13916975_SNP [dm3] 3L_13923875_SNP [dm6]	C	T	2.395e^-5	1	INTRON Rgl	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_Trl
2L	9764578	2L_9764578_SNP [dm3] 2L_9764578_SNP [dm6]	C	A	2.458e^-5	1	SYNONYMOUS_CODING und DOWNSTREAM ppk18	TF binding site mE1_TFBS_cad
X	8062944	X_8062944_SNP [dm3] X_8168911_SNP [dm6]	A	T	2.723e^-5	1	INTRON CG2278	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
3R	2586734	3R_2586734_SNP [dm3] 3R_6761012_SNP [dm6]	A	G	2.881e^-5	1	DOWNSTREAM CR45593 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_ftz BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_Stat92E
3L	530282	3L_530282_SNP [dm3] 3L_530282_SNP [dm6]	G	C	2.892e^-5	1	INTRON klar
3L	8737992	3L_8737992_SNP [dm3] 3L_8744892_SNP [dm6]	A	C	3.298e^-5	1	INTRON Prm	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA
2L	3861183	2L_3861183_SNP [dm3] 2L_3861183_SNP [dm6]	T	C	3.382e^-5	1	DOWNSTREAM CR44078 INTERGENIC	silencer mE1_HDAC_PRE TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_slp1 BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	15858011	3L_15858011_SNP [dm3] 3L_15864911_SNP [dm6]	C	A	3.629e^-5	1	INTRON pHCl
2L	6817002	2L_6817002_DEL [dm3] 2L_6817002_DEL [dm6]	ATAGCGAA	A	3.635e^-5	1	INTERGENIC
2L	6817012	2L_6817012_SNP [dm3] 2L_6817012_SNP [dm6]	T	C	3.635e^-5	1	INTERGENIC
2L	6817015	2L_6817015_SNP [dm3] 2L_6817015_SNP [dm6]	C	A	3.635e^-5	1	INTERGENIC
2L	6817020	2L_6817020_DEL [dm3] 2L_6817020_DEL [dm6]	TC	A	3.635e^-5	1	INTERGENIC
X	21148942	X_21148942_SNP [dm3] X_21277915_SNP [dm6]	A	G	3.759e^-5	1	INTRON CG32521
X	18700583	X_18700583_SNP [dm3] X_18806550_SNP [dm6]	A	G	3.780e^-5	1	UPSTREAM CG7058 & 1 other DOWNSTREAM Pk17E INTERGENIC	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2L	14249827	2L_14249827_SNP [dm3] 2L_14249827_SNP [dm6]	A	T	3.825e^-5	1	INTERGENIC
2L	7262991	2L_7262991_SNP [dm3] 2L_7262991_SNP [dm6]	G	A	4.021e^-5	1	INTRON Wnt4	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
X	12849231	X_12849231_INS [dm3] X_12955198_INS [dm6]	A	AGAAACACA	4.026e^-5	1	INTRON hec
X	9689692	X_9689692_SNP [dm3] X_9795659_SNP [dm6]	T	G	4.090e^-5	1	INTRON CG32698
2L	19799519	2L_19799519_SNP [dm3] 2L_19799519_SNP [dm6]	T	A	4.152e^-5	1	INTRON sick	TF binding site mE1_TFBS_cad
2L	3299887	2L_3299887_SNP [dm3] 2L_3299887_SNP [dm6]	T	G	4.200e^-5	1	INTRON CG9663	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
3L	9965398	3L_9965398_SNP [dm3] 3L_9972298_SNP [dm6]	A	T	4.445e^-5	1	UPSTREAM vnc & 2 others INTERGENIC	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_D mE1_TFBS_hkb mE1_TFBS_HSA mE1_TFBS_sens mE1_TFBS_Ubx
3L	4133259	3L_4133259_SNP [dm3] 3L_4133259_SNP [dm6]	G	C	4.669e^-5	1	INTRON ens	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	14992543	2R_14992543_SNP [dm3] 2R_19105038_SNP [dm6]	G	A	4.688e^-5	1	INTRON 5-HT1A
2R	14992561	2R_14992561_SNP [dm3] 2R_19105056_SNP [dm6]	A	T	4.753e^-5	1	INTRON 5-HT1A
3R	9675733	3R_9675733_SNP [dm3] 3R_13850011_SNP [dm6]	T	A	5.036e^-5	1	INTERGENIC
3L	8835411	3L_8835411_SNP [dm3] 3L_8842311_SNP [dm6]	T	A	5.150e^-5	1	INTRON dally
3L	9962939	3L_9962939_SNP [dm3] 3L_9969839_SNP [dm6]	C	T	5.213e^-5	1	INTRON Nc
X	8988935	X_8988935_SNP [dm3] X_9094902_SNP [dm6]	C	T	5.226e^-5	1	SYNONYMOUS_CODING CG7766	TF binding site BDTNP1_TFBS_dl mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
2R	7602336	2R_7602336_SNP [dm3] 2R_11714831_SNP [dm6]	C	G	5.242e^-5	1	INTRON pyr
X	5701631	X_5701631_SNP [dm3] X_5807598_SNP [dm6]	G	C	5.271e^-5	1	INTERGENIC
2L	6817017	2L_6817017_SNP [dm3] 2L_6817017_SNP [dm6]	T	G	5.308e^-5	1	INTERGENIC
3L	13793625	3L_13793625_SNP [dm3] 3L_13800525_SNP [dm6]	A	G	5.375e^-5	1	INTRON bru-3
2L	13293022	2L_13293022_SNP [dm3] 2L_13293022_SNP [dm6]	T	G	5.734e^-5	1	UTR_5_PRIME CG16824 INTRON CG31729
X	1180662	X_1180662_SNP [dm3] X_1286629_SNP [dm6]	G	A	5.917e^-5	1	UPSTREAM CG32812 INTERGENIC	TF binding site BDTNP1_TFBS_dl mE1_TFBS_bab1 mE1_TFBS_D mE1_TFBS_disco mE1_TFBS_h mE1_TFBS_hkb mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_jumu mE1_TFBS_run mE1_TFBS_sens
X	13060061	X_13060061_SNP [dm3] X_13166028_SNP [dm6]	G	A	6.042e^-5	1	INTRON CG34411
2L	9649188	2L_9649188_SNP [dm3] 2L_9649188_SNP [dm6]	C	T	6.165e^-5	1	INTRON Apoltp
2R	17991446	2R_17991446_SNP [dm3] 2R_22103941_SNP [dm6]	G	T	6.306e^-5	1	SPLICE_SITE_REGION CG6613 SYNONYMOUS_CODING CG6613
X	5591160	X_5591160_SNP [dm3] X_5697127_SNP [dm6]	T	C	6.321e^-5	1	EXON CR42794	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med
2L	5678134	2L_5678134_SNP [dm3] 2L_5678134_SNP [dm6]	C	T	6.373e^-5	1	UPSTREAM CG12511 INTERGENIC
X	4877610	X_4877610_SNP [dm3] X_4983577_SNP [dm6]	C	T	6.448e^-5	1	INTRON CR44833	regulatory region REDfly_CRMs
X	12083984	X_12083984_SNP [dm3] X_12189951_SNP [dm6]	C	A	6.503e^-5	1	INTRON Ten-a
3L	6671934	3L_6671934_SNP [dm3] 3L_6678834_SNP [dm6]	T	G	6.597e^-5	1	INTERGENIC
3R	25691636	3R_25691636_SNP [dm3] 3R_29865914_SNP [dm6]	A	T	6.668e^-5	1	UPSTREAM Zip99C INTRON Zip99C
2L	10826429	2L_10826429_SNP [dm3] 2L_10826429_SNP [dm6]	T	C	6.719e^-5	1	INTRON Nos
X	17419140	X_17419140_SNP [dm3] X_17525107_SNP [dm6]	G	A	6.795e^-5	1	INTRON CG43658
X	17419143	X_17419143_SNP [dm3] X_17525110_SNP [dm6]	G	C	6.795e^-5	1	INTRON CG43658
3L	4618296	3L_4618296_SNP [dm3] 3L_4618296_SNP [dm6]	A	T	6.990e^-5	1	INTRON Src64B
X	18700584	X_18700584_SNP [dm3] X_18806551_SNP [dm6]	C	T	7.026e^-5	1	UPSTREAM CG7058 & 1 other DOWNSTREAM Pk17E INTERGENIC	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2L	551990	2L_551990_SNP [dm3] 2L_551990_SNP [dm6]	G	T	7.107e^-5	1	UTR_5_PRIME Ets21C
3L	13448600	3L_13448600_SNP [dm3] 3L_13455500_SNP [dm6]	G	T	7.189e^-5	1	DOWNSTREAM CG10116 INTRON CG10738
2L	3235770	2L_3235770_SNP [dm3] 2L_3235770_SNP [dm6]	T	C	7.268e^-5	1	INTERGENIC
2R	18661697	2R_18661697_SNP [dm3] 2R_22774192_SNP [dm6]	G	A	7.356e^-5	1	INTRON CG42260
3L	1688659	3L_1688659_SNP [dm3] 3L_1688659_SNP [dm6]	C	T	7.392e^-5	1	UPSTREAM CG7991 INTRON CG7991	TF binding site BDTNP1_TFBS_twi
3L	14106758	3L_14106758_SNP [dm3] 3L_14113658_SNP [dm6]	T	C	7.485e^-5	1	INTRON Sox21b
3L	14106760	3L_14106760_SNP [dm3] 3L_14113660_SNP [dm6]	A	T	7.485e^-5	1	INTRON Sox21b
3L	14106763	3L_14106763_SNP [dm3] 3L_14113663_SNP [dm6]	A	G	7.485e^-5	1	INTRON Sox21b
3L	14106765	3L_14106765_SNP [dm3] 3L_14113665_SNP [dm6]	T	G	7.485e^-5	1	INTRON Sox21b
3L	14106767	3L_14106767_DEL [dm3] 3L_14113667_DEL [dm6]	TGAATTAA	T	7.485e^-5	1	INTRON Sox21b
X	5575052	X_5575052_SNP [dm3] X_5681019_SNP [dm6]	T	C	7.544e^-5	1	SYNONYMOUS_CODING Gr5a EXON CR44958
2L	14249832	2L_14249832_SNP [dm3] 2L_14249832_SNP [dm6]	T	A	7.637e^-5	1	INTERGENIC
3L	15857924	3L_15857924_SNP [dm3] 3L_15864824_SNP [dm6]	C	T	7.839e^-5	1	INTRON pHCl
3L	22953929	3L_22953929_SNP [dm3] 3L_22960829_SNP [dm6]	A	G	7.875e^-5	1	UPSTREAM CR45758 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens mE1_TFBS_Trl
X	9637173	X_9637173_SNP [dm3] X_9743140_SNP [dm6]	C	T	7.910e^-5	1	INTRON Sp1
2R	5691057	2R_5691057_SNP [dm3] 2R_9803552_SNP [dm6]	G	T	8.048e^-5	1	INTRON CG1688
3L	11146917	3L_11146917_SNP [dm3] 3L_11153817_SNP [dm6]	C	G	8.087e^-5	1	INTRON CG32082
3L	14196470	3L_14196470_SNP [dm3] 3L_14203370_SNP [dm6]	G	T	8.120e^-5	1	UTR_5_PRIME CG32141 INTRON nuf
X	14815711	X_14815711_SNP [dm3] X_14921678_SNP [dm6]	T	A	8.199e^-5	1	UTR_5_PRIME CG9503 INTRON Flo2
3R	2586728	3R_2586728_SNP [dm3] 3R_6761006_SNP [dm6]	T	A	8.277e^-5	1	DOWNSTREAM CR45593 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_ftz BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_Stat92E
2L	14249831	2L_14249831_SNP [dm3] 2L_14249831_SNP [dm6]	C	T	8.290e^-5	1	INTERGENIC
2R	17597604	2R_17597604_SNP [dm3] 2R_21710099_SNP [dm6]	C	T	8.321e^-5	1	UTR_3_PRIME CG30403 UPSTREAM CR44749 INTRON HmgD	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_HSA
3L	1120728	3L_1120728_SNP [dm3] 3L_1120728_SNP [dm6]	A	T	8.323e^-5	1	INTERGENIC
2L	7434143	2L_7434143_SNP [dm3] 2L_7434143_SNP [dm6]	A	C	8.353e^-5	1	UPSTREAM CG5958 INTERGENIC
3L	14106749	3L_14106749_SNP [dm3] 3L_14113649_SNP [dm6]	T	G	8.365e^-5	1	INTRON Sox21b
3L	8738015	3L_8738015_SNP [dm3] 3L_8744915_SNP [dm6]	A	T	8.372e^-5	1	INTRON Prm	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA
3L	4788001	3L_4788001_SNP [dm3] 3L_4788001_SNP [dm6]	G	C	8.496e^-5	1	INTRON RhoGEF64C
X	4132449	X_4132449_SNP [dm3] X_4238416_SNP [dm6]	C	T	8.549e^-5	1	INTERGENIC
X	7999255	X_7999255_SNP [dm3] X_8105222_SNP [dm6]	T	C	8.571e^-5	1	INTRON Gclc	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_inv

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Phenotype distribution and association to known covariates

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