©2022-2025 Deplancke lab, EPFL, 1015 Lausanne
By genomic position | |
Variant impact | |
Gene name |
Involved in binding site | |
Binding site |
Chromosome | Position | ID | Reference | Variant | p-value | FDR_BH | Transcript annotation | Binding site annotation | |
---|---|---|---|---|---|---|---|---|---|
3R | 15012988 | 3R_15012988_INS [dm3] 3R_19187266_INS [dm6] | C | GCTCT | 1.879e-6 | 0.943 |
INTRON
CG31475 |
TF binding site
mE1_TFBS_inv
|
|
3R | 15012994 | 3R_15012994_SNP [dm3] 3R_19187272_SNP [dm6] | T | G | 2.930e-6 | 0.943 |
INTRON
CG31475 |
TF binding site
mE1_TFBS_inv
|
|
3R | 15852506 | 3R_15852506_SNP [dm3] 3R_20026784_SNP [dm6] | C | T | 3.957e-6 | 0.943 |
DOWNSTREAM
psidin INTRON CG4424 |
||
2L | 19856691 | 2L_19856691_SNP [dm3] 2L_19856691_SNP [dm6] | G | A | 4.531e-6 | 0.943 |
INTRON
sick |
||
2R | 13771330 | 2R_13771330_SNP [dm3] 2R_17883825_SNP [dm6] | G | A | 6.942e-6 | 0.943 |
INTRON
Elk |
||
3L | 9946310 | 3L_9946310_SNP [dm3] 3L_9953210_SNP [dm6] | C | T | 6.983e-6 | 0.943 |
INTRON
CG34356 |
||
2R | 10171811 | 2R_10171811_SNP [dm3] 2R_14284306_SNP [dm6] | T | A | 7.047e-6 | 0.943 |
INTRON
Ih |
TF binding site
mE1_TFBS_cad mE1_TFBS_HSA
|
|
2L | 19923189 | 2L_19923189_SNP [dm3] 2L_19923189_SNP [dm6] | T | C | 7.072e-6 | 0.943 |
INTRON
sick & 1 other EXON CR43827 |
||
2L | 20335041 | 2L_20335041_SNP [dm3] 2L_20335041_SNP [dm6] | A | C | 7.225e-6 | 0.943 |
INTRON
spir |
||
2L | 20862470 | 2L_20862470_SNP [dm3] 2L_20862470_SNP [dm6] | G | A | 7.734e-6 | 0.943 |
DOWNSTREAM
CR9337 INTERGENIC |
||
3R | 9585911 | 3R_9585911_SNP [dm3] 3R_13760189_SNP [dm6] | C | T | 9.158e-6 | 0.943 |
INTRON
CG34383 |
||
2R | 13628030 | 2R_13628030_SNP [dm3] 2R_17740525_SNP [dm6] | G | A | 1.199e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2R | 13628009 | 2R_13628009_SNP [dm3] 2R_17740504_SNP [dm6] | G | A | 1.216e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2R | 13628012 | 2R_13628012_SNP [dm3] 2R_17740507_SNP [dm6] | C | G | 1.218e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2L | 7701220 | 2L_7701220_SNP [dm3] 2L_7701220_SNP [dm6] | T | A | 1.236e-5 | 0.943 |
INTRON
Tep2 |
TF binding site
mE1_TFBS_Trl
|
|
3L | 17919798 | 3L_17919798_SNP [dm3] 3L_17926698_SNP [dm6] | G | A | 1.252e-5 | 0.943 |
INTERGENIC
|
TF binding site
mE1_TFBS_HSA mE1_TFBS_sbb
|
|
X | 3516415 | X_3516415_DEL [dm3] X_3622382_DEL [dm6] | TT | T | 1.354e-5 | 0.943 |
INTRON
AstA-R1 |
||
3L | 10775124 | 3L_10775124_SNP [dm3] 3L_10782024_SNP [dm6] | A | T | 1.445e-5 | 0.943 |
INTERGENIC
|
||
2L | 6107755 | 2L_6107755_SNP [dm3] 2L_6107755_SNP [dm6] | A | T | 1.628e-5 | 0.943 |
INTRON
stai |
||
2R | 6464832 | 2R_6464832_SNP [dm3] 2R_10577327_SNP [dm6] | A | G | 1.702e-5 | 0.943 |
INTRON
psq |
||
2R | 8672361 | 2R_8672361_SNP [dm3] 2R_12784856_SNP [dm6] | A | T | 1.709e-5 | 0.943 |
INTRON
sca & 1 other |
regulatory region
REDfly_CRMs
|
|
3R | 25208577 | 3R_25208577_INS [dm3] 3R_29382855_INS [dm6] | A | ATACA | 1.716e-5 | 0.943 |
INTRON
Ptp99A |
||
2L | 18882851 | 2L_18882851_SNP [dm3] 2L_18882851_SNP [dm6] | T | C | 1.938e-5 | 0.943 |
INTERGENIC
|
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
|
|
3R | 16479528 | 3R_16479528_SNP [dm3] 3R_20653806_SNP [dm6] | G | T | 2.111e-5 | 0.943 |
SYNONYMOUS_CODING
Nep4 |
TF binding site
mE1_TFBS_cad
|
|
3L | 14731962 | 3L_14731962_SNP [dm3] 3L_14738862_SNP [dm6] | T | C | 2.136e-5 | 0.943 |
INTRON
ome |
||
X | 11629664 | X_11629664_SNP [dm3] X_11735631_SNP [dm6] | C | G | 2.175e-5 | 0.943 |
NON_SYNONYMOUS_CODING
CG15221 |
||
2L | 13274279 | 2L_13274279_SNP [dm3] 2L_13274279_SNP [dm6] | T | A | 2.179e-5 | 0.943 |
INTRON
CG44085 |
||
3L | 3412396 | 3L_3412396_SNP [dm3] 3L_3412396_SNP [dm6] | T | C | 2.243e-5 | 0.943 |
UPSTREAM
mir-2282 INTRON sty |
||
3R | 16479675 | 3R_16479675_SNP [dm3] 3R_20653953_SNP [dm6] | A | G | 2.278e-5 | 0.943 |
SYNONYMOUS_CODING
Nep4 |
TF binding site
mE1_TFBS_cad
|
|
2L | 5913141 | 2L_5913141_SNP [dm3] 2L_5913141_SNP [dm6] | C | T | 2.341e-5 | 0.943 |
SYNONYMOUS_CODING
bchs |
||
2R | 13627997 | 2R_13627997_SNP [dm3] 2R_17740492_SNP [dm6] | T | C | 2.372e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
3L | 4325125 | 3L_4325125_SNP [dm3] 3L_4325125_SNP [dm6] | G | A | 2.423e-5 | 0.943 |
NON_SYNONYMOUS_CODING
Cip4 |
||
2L | 6834406 | 2L_6834406_SNP [dm3] 2L_6834406_SNP [dm6] | A | G | 2.462e-5 | 0.943 |
INTRON
sens-2 |
silencer
mE1_HDAC_PRE
TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl |
|
3R | 25520225 | 3R_25520225_SNP [dm3] 3R_29694503_SNP [dm6] | A | T | 2.487e-5 | 0.943 |
INTRON
dmrt99B |
||
2R | 7451746 | 2R_7451746_SNP [dm3] 2R_11564241_SNP [dm6] | G | T | 2.510e-5 | 0.943 |
INTERGENIC
|
||
2R | 6965120 | 2R_6965120_SNP [dm3] 2R_11077615_SNP [dm6] | C | T | 2.514e-5 | 0.943 |
INTRON
luna |
TF binding site
mE1_TFBS_HSA
|
|
3R | 25515655 | 3R_25515655_SNP [dm3] 3R_29689933_SNP [dm6] | A | C | 2.572e-5 | 0.943 |
UPSTREAM
Obp99c INTERGENIC |
silencer
mE1_HDAC_PRE
TF binding site mE1_TFBS_Trl |
|
X | 14426280 | X_14426280_SNP [dm3] X_14532247_SNP [dm6] | G | A | 2.628e-5 | 0.943 |
INTERGENIC
|
||
2R | 4978866 | 2R_4978866_SNP [dm3] 2R_9091361_SNP [dm6] | G | A | 2.696e-5 | 0.943 |
INTRON
CG8080 |
||
2R | 4978872 | 2R_4978872_SNP [dm3] 2R_9091367_SNP [dm6] | C | A | 2.696e-5 | 0.943 |
INTRON
CG8080 |
||
3L | 3463947 | 3L_3463947_SNP [dm3] 3L_3463947_SNP [dm6] | G | A | 2.730e-5 | 0.943 |
SYNONYMOUS_CODING
armi |
||
2L | 20327490 | 2L_20327490_SNP [dm3] 2L_20327490_SNP [dm6] | T | A | 2.801e-5 | 0.943 |
INTRON
spir |
||
3L | 15402265 | 3L_15402265_SNP [dm3] 3L_15409165_SNP [dm6] | T | A | 2.896e-5 | 0.943 |
DOWNSTREAM
CG33259 INTERGENIC |
||
3R | 6504570 | 3R_6504570_SNP [dm3] 3R_10678848_SNP [dm6] | G | T | 2.972e-5 | 0.943 |
NON_SYNONYMOUS_CODING
CG14688 |
TF binding site
mE1_TFBS_chinmo mE1_TFBS_sens
|
|
2R | 4978850 | 2R_4978850_SNP [dm3] 2R_9091345_SNP [dm6] | T | G | 3.013e-5 | 0.943 |
INTRON
CG8080 |
||
3L | 3463659 | 3L_3463659_SNP [dm3] 3L_3463659_SNP [dm6] | G | A | 3.047e-5 | 0.943 |
SYNONYMOUS_CODING
armi |
||
X | 10026153 | X_10026153_SNP [dm3] X_10132120_SNP [dm6] | T | C | 3.068e-5 | 0.943 |
INTRON
CR44894 & 1 other |
||
3L | 11038442 | 3L_11038442_SNP [dm3] 3L_11045342_SNP [dm6] | A | G | 3.071e-5 | 0.943 |
INTRON
CG43693 |
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_sens mE1_TFBS_Trl
|
|
3R | 19431381 | 3R_19431381_SNP [dm3] 3R_23605659_SNP [dm6] | A | G | 3.109e-5 | 0.943 |
UPSTREAM
CG10184 DOWNSTREAM CG31145 INTERGENIC |
||
2L | 20388956 | 2L_20388956_SNP [dm3] 2L_20388956_SNP [dm6] | G | A | 3.270e-5 | 0.943 |
INTRON
CG10947 |
||
3L | 12335189 | 3L_12335189_SNP [dm3] 3L_12342089_SNP [dm6] | T | C | 3.358e-5 | 0.943 |
INTRON
CrzR |
||
3R | 25316690 | 3R_25316690_SNP [dm3] 3R_29490968_SNP [dm6] | G | A | 3.448e-5 | 0.943 |
UTR_3_PRIME
CG2006 DOWNSTREAM CG2310 & 1 other INTRON Spase12 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_HSA
|
|
2L | 20226742 | 2L_20226742_SNP [dm3] 2L_20226742_SNP [dm6] | C | A | 3.686e-5 | 0.943 |
INTERGENIC
|
||
2R | 17583321 | 2R_17583321_SNP [dm3] 2R_21695816_SNP [dm6] | G | A | 3.691e-5 | 0.943 |
SYNONYMOUS_CODING
CngB |
TF binding site
mE1_TFBS_cad
|
|
2R | 13628162 | 2R_13628162_SNP [dm3] 2R_17740657_SNP [dm6] | G | A | 3.759e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2R | 13627976 | 2R_13627976_SNP [dm3] 2R_17740471_SNP [dm6] | G | A | 3.760e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2R | 3552794 | 2R_3552794_SNP [dm3] 2R_7665289_SNP [dm6] | T | A | 3.805e-5 | 0.943 |
UPSTREAM
CG2064 DOWNSTREAM CG2065 INTERGENIC |
TF binding site
BDTNP1_TFBS_Med
|
|
3L | 5914586 | 3L_5914586_DEL [dm3] 3L_5921486_DEL [dm6] | ACAACA | A | 3.807e-5 | 0.943 |
UPSTREAM
CG32407 & 1 other INTERGENIC |
||
2L | 14051068 | 2L_14051068_SNP [dm3] 2L_14051068_SNP [dm6] | C | A | 3.846e-5 | 0.943 |
INTRON
nAChRalpha5 |
TF binding site
BDTNP1_TFBS_dl mE1_TFBS_chinmo mE1_TFBS_HSA
|
|
3R | 19181525 | 3R_19181525_SNP [dm3] 3R_23355803_SNP [dm6] | T | A | 3.901e-5 | 0.943 |
UPSTREAM
Sec13 DOWNSTREAM DNApol-epsilon INTRON ATPsyn-Cf6 |
TF binding site
BDTNP1_TFBS_z mE1_TFBS_HSA
|
|
2L | 16374926 | 2L_16374926_SNP [dm3] 2L_16374926_SNP [dm6] | A | T | 3.923e-5 | 0.943 |
INTERGENIC
|
||
2R | 8672444 | 2R_8672444_SNP [dm3] 2R_12784939_SNP [dm6] | C | G | 3.964e-5 | 0.943 |
INTRON
sca EXON CR45137 |
regulatory region
REDfly_CRMs
|
|
3L | 3462787 | 3L_3462787_SNP [dm3] 3L_3462787_SNP [dm6] | A | T | 4.007e-5 | 0.943 |
SPLICE_SITE_REGION
armi INTRON armi |
TF binding site
mE1_TFBS_HSA mE1_TFBS_sens
|
|
3L | 5914965 | 3L_5914965_SNP [dm3] 3L_5921865_SNP [dm6] | A | T | 4.065e-5 | 0.943 |
UPSTREAM
CG32407 & 1 other INTERGENIC |
TF binding site
mE1_TFBS_cad
|
|
3R | 25723445 | 3R_25723445_DEL [dm3] 3R_29897723_DEL [dm6] | ATA | A | 4.095e-5 | 0.943 |
UTR_3_PRIME
CG31038 INTRON CG31038 |
TF binding site
mE1_TFBS_chinmo
|
|
2R | 13628027 | 2R_13628027_SNP [dm3] 2R_17740522_SNP [dm6] | G | A | 4.125e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
2L | 9983800 | 2L_9983800_SNP [dm3] 2L_9983800_SNP [dm6] | C | T | 4.211e-5 | 0.943 |
UPSTREAM
bib EXON CR13130 |
regulatory region
REDfly_CRMs
TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi |
|
3L | 11349631 | 3L_11349631_SNP [dm3] 3L_11356531_SNP [dm6] | C | A | 4.488e-5 | 0.943 |
INTERGENIC
|
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_ftz BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
|
|
X | 12946422 | X_12946422_SNP [dm3] X_13052389_SNP [dm6] | G | A | 4.778e-5 | 0.943 |
DOWNSTREAM
CG12715 INTRON rad |
||
2L | 6042641 | 2L_6042641_SNP [dm3] 2L_6042641_SNP [dm6] | C | G | 4.912e-5 | 0.943 |
NON_SYNONYMOUS_CODING
ade2 |
TF binding site
mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_sens
|
|
X | 2754643 | X_2754643_SNP [dm3] X_2860610_SNP [dm6] | A | T | 4.993e-5 | 0.943 |
INTRON
kirre |
||
3L | 12017812 | 3L_12017812_SNP [dm3] 3L_12024712_SNP [dm6] | G | A | 5.010e-5 | 0.943 |
INTRON
rols |
||
2R | 19668908 | 2R_19668908_SNP [dm3] 2R_23781385_SNP [dm6] | G | T | 5.097e-5 | 0.943 |
INTRON
CG9850 |
||
3R | 10962657 | 3R_10962657_SNP [dm3] 3R_15136935_SNP [dm6] | C | G | 5.113e-5 | 0.943 |
UTR_5_PRIME
CG6912 UPSTREAM CG3984 DOWNSTREAM CR45600 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_hb mE1_TFBS_cad
|
|
3R | 26796056 | 3R_26796056_SNP [dm3] 3R_30970334_SNP [dm6] | T | A | 5.157e-5 | 0.943 |
SYNONYMOUS_CODING
5-HT7 |
TF binding site
mE1_TFBS_cad mE1_TFBS_chinmo
|
|
2L | 9192101 | 2L_9192101_SNP [dm3] 2L_9192101_SNP [dm6] | C | T | 5.220e-5 | 0.943 |
INTRON
tai |
||
2R | 13628078 | 2R_13628078_SNP [dm3] 2R_17740573_SNP [dm6] | G | A | 5.240e-5 | 0.943 |
SYNONYMOUS_CODING
CG4996 UPSTREAM CG6401 |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_sens
|
|
X | 13808652 | X_13808652_SNP [dm3] X_13914619_SNP [dm6] | T | C | 5.250e-5 | 0.943 |
INTRON
mamo |
||
2R | 14646899 | 2R_14646899_SNP [dm3] 2R_18759394_SNP [dm6] | A | C | 5.258e-5 | 0.943 |
SYNONYMOUS_CODING
Jabba |
||
3L | 5373981 | 3L_5373981_SNP [dm3] 3L_5380881_SNP [dm6] | G | A | 5.268e-5 | 0.943 |
INTRON
Ir64a |
||
X | 21138053 | X_21138053_SNP [dm3] X_21267026_SNP [dm6] | T | C | 5.362e-5 | 0.943 |
INTRON
CG32521 |
||
3L | 10775115 | 3L_10775115_SNP [dm3] 3L_10782015_SNP [dm6] | G | A | 5.417e-5 | 0.943 |
INTERGENIC
|
||
3R | 25316616 | 3R_25316616_SNP [dm3] 3R_29490894_SNP [dm6] | A | G | 5.455e-5 | 0.943 |
SYNONYMOUS_CODING
Spase12 UTR_3_PRIME CG2006 DOWNSTREAM CG2310 & 1 other |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_HSA
|
|
3L | 14732064 | 3L_14732064_SNP [dm3] 3L_14738964_SNP [dm6] | C | T | 5.478e-5 | 0.943 |
INTRON
ome |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_twi
|
|
3R | 17993103 | 3R_17993103_SNP [dm3] 3R_22167381_SNP [dm6] | G | C | 5.491e-5 | 0.943 |
INTRON
SKIP |
TF binding site
mE1_TFBS_Kr
|
|
2L | 16195018 | 2L_16195018_SNP [dm3] 2L_16195018_SNP [dm6] | G | A | 5.509e-5 | 0.943 |
DOWNSTREAM
CR44735 EXON CR44734 |
||
2R | 19791700 | 2R_19791700_SNP [dm3] 2R_23904177_SNP [dm6] | T | C | 5.532e-5 | 0.943 |
SYNONYMOUS_CODING
CG13562 DOWNSTREAM Lpt & 1 other |
||
3R | 15843652 | 3R_15843652_SNP [dm3] 3R_20017930_SNP [dm6] | A | T | 5.540e-5 | 0.943 |
SYNONYMOUS_CODING
CG4836 UTR_3_PRIME CG4836 DOWNSTREAM CG4433 |
TF binding site
mE1_TFBS_cad
|
|
X | 21138054 | X_21138054_SNP [dm3] X_21267027_SNP [dm6] | T | C | 5.577e-5 | 0.943 |
INTRON
CG32521 |
||
3R | 26459341 | 3R_26459341_SNP [dm3] 3R_30633619_SNP [dm6] | C | T | 5.630e-5 | 0.943 |
INTERGENIC
|
||
3R | 16479672 | 3R_16479672_SNP [dm3] 3R_20653950_SNP [dm6] | C | T | 5.639e-5 | 0.943 |
SYNONYMOUS_CODING
Nep4 |
TF binding site
mE1_TFBS_cad
|
|
2R | 7570166 | 2R_7570166_SNP [dm3] 2R_11682661_SNP [dm6] | T | C | 5.659e-5 | 0.943 |
INTRON
Buffy |
||
X | 13808627 | X_13808627_SNP [dm3] X_13914594_SNP [dm6] | A | G | 5.791e-5 | 0.943 |
INTRON
mamo |
||
3R | 16479570 | 3R_16479570_SNP [dm3] 3R_20653848_SNP [dm6] | A | G | 5.818e-5 | 0.943 |
SYNONYMOUS_CODING
Nep4 |
TF binding site
mE1_TFBS_cad
|
|
3L | 16981484 | 3L_16981484_SNP [dm3] 3L_16988384_SNP [dm6] | C | T | 5.830e-5 | 0.943 |
INTRON
Exn |
||
3L | 3446253 | 3L_3446253_SNP [dm3] 3L_3446253_SNP [dm6] | G | C | 5.854e-5 | 0.943 |
INTRON
eIF5B |
||
2L | 14000232 | 2L_14000232_SNP [dm3] 2L_14000232_SNP [dm6] | T | A | 5.868e-5 | 0.943 |
INTRON
rk |
||
X | 18368681 | X_18368681_INS [dm3] X_18474648_INS [dm6] | C | CTC | 5.956e-5 | 0.943 |
INTRON
CG32547 |
||
3L | 1521077 | 3L_1521077_SNP [dm3] 3L_1521077_SNP [dm6] | A | T | 5.959e-5 | 0.943 |
INTRON
Psa |
TF binding site
mE1_TFBS_cad
|
|
X | 12780558 | X_12780558_SNP [dm3] X_12886525_SNP [dm6] | A | T | 5.976e-5 | 0.943 |
INTRON
Pde9 |