DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=1.040e^-3)
Null Hypothesis is rejected (p<=0.05).
Interpretation: NOT NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test

Covariate	p-value	Significance
In_2L_t	6.658e-05
In_3R_P	0.05773

Kruskal-Wallis test

Covariate	χ²	p-value	Significance

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

2072 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
2R	11800356	2R_11800356_SNP [dm3] 2R_15912851_SNP [dm6]	T	C	9.990e^-8	0.187	INTRON sli	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Kr
2L	14932786	2L_14932786_SNP [dm3] 2L_14932786_SNP [dm6]	A	C	1.147e^-6	0.717	INTRON CG42313
2R	2464467	2R_2464467_SNP [dm3] 2R_6576962_SNP [dm6]	C	G	1.884e^-6	0.717	INTRON jing	TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	14586905	2R_14586905_SNP [dm3] 2R_18699400_SNP [dm6]	A	C	2.012e^-6	0.717	SYNONYMOUS_CODING Sik3
3R	9864205	3R_9864205_SNP [dm3] 3R_14038483_SNP [dm6]	C	A	2.433e^-6	0.717	INTERGENIC
3L	8244023	3L_8244023_SNP [dm3] 3L_8250923_SNP [dm6]	G	C	2.744e^-6	0.717	INTRON Dscam4
2L	11203841	2L_11203841_SNP [dm3] 2L_11203841_SNP [dm6]	T	A	2.906e^-6	0.717	UPSTREAM Ca-beta INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
2R	7426885	2R_7426885_SNP [dm3] 2R_11539380_SNP [dm6]	C	G	3.119e^-6	0.717	INTERGENIC
2L	20906431	2L_20906431_SNP [dm3] 2L_20906431_SNP [dm6]	A	T	3.439e^-6	0.717	INTRON sky & 1 other
2R	7426702	2R_7426702_SNP [dm3] 2R_11539197_SNP [dm6]	G	C	4.315e^-6	0.809	INTERGENIC
2L	21760181	2L_21760181_SNP [dm3] 2L_21760181_SNP [dm6]	C	A	5.200e^-6	0.863	INTRON CG1416
2L	20906433	2L_20906433_DEL [dm3] 2L_20906433_DEL [dm6]	CTTCT	A	5.544e^-6	0.863	INTRON sky & 1 other
2R	11800211	2R_11800211_SNP [dm3] 2R_15912706_SNP [dm6]	A	C	7.163e^-6	0.863	INTRON sli	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Kr
2R	10860499	2R_10860499_SNP [dm3] 2R_14972994_SNP [dm6]	C	A	8.591e^-6	0.863	INTRON ckn	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	9864857	3R_9864857_SNP [dm3] 3R_14039135_SNP [dm6]	G	T	8.625e^-6	0.863	INTERGENIC
3R	9864856	3R_9864856_SNP [dm3] 3R_14039134_SNP [dm6]	G	A	9.357e^-6	0.863	INTERGENIC
3L	13199363	3L_13199363_DEL [dm3] 3L_13206263_DEL [dm6]	TCGC	T	9.888e^-6	0.863	INTERGENIC
2L	14745455	2L_14745455_SNP [dm3] 2L_14745455_SNP [dm6]	A	C	1.054e^-5	0.863	UPSTREAM CR45459 & 1 other DOWNSTREAM CG42681 EXON CR45460
2R	9048165	2R_9048165_SNP [dm3] 2R_13160660_SNP [dm6]	G	A	1.078e^-5	0.863	DOWNSTREAM CG34439 INTRON Nrk	TF binding site mE1_TFBS_HSA
2L	20690724	2L_20690724_SNP [dm3] 2L_20690724_SNP [dm6]	A	T	1.235e^-5	0.863	INTRON Hr38	TF binding site BDTNP1_TFBS_prd mE1_TFBS_cad mE1_TFBS_HSA
3L	8246366	3L_8246366_SNP [dm3] 3L_8253266_SNP [dm6]	G	C	1.273e^-5	0.863	INTRON Dscam4
2L	12175796	2L_12175796_SNP [dm3] 2L_12175796_SNP [dm6]	A	C	1.442e^-5	0.863	INTRON aret & 1 other	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
3R	9864570	3R_9864570_SNP [dm3] 3R_14038848_SNP [dm6]	G	A	1.489e^-5	0.863	INTERGENIC
3R	23345353	3R_23345353_SNP [dm3] 3R_27519631_SNP [dm6]	C	T	1.505e^-5	0.863	INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
2L	21759480	2L_21759480_SNP [dm3] 2L_21759480_SNP [dm6]	C	T	1.507e^-5	0.863	INTRON CG1416
3R	26070149	3R_26070149_SNP [dm3] 3R_30244427_SNP [dm6]	G	A	1.564e^-5	0.863	SYNONYMOUS_CODING CG9733	TF binding site mE1_TFBS_chinmo
3L	8243798	3L_8243798_SNP [dm3] 3L_8250698_SNP [dm6]	G	A	1.593e^-5	0.863	INTRON Dscam4	TF binding site mE1_TFBS_chinmo
2L	20618078	2L_20618078_SNP [dm3] 2L_20618078_SNP [dm6]	T	C	1.666e^-5	0.863	DOWNSTREAM mir-288 INTRON CR44909
3R	13436284	3R_13436284_SNP [dm3] 3R_17610562_SNP [dm6]	T	C	1.678e^-5	0.863	DOWNSTREAM Edg91 & 1 other INTERGENIC
2R	18539080	2R_18539080_SNP [dm3] 2R_22651575_SNP [dm6]	G	A	1.741e^-5	0.863	SYNONYMOUS_CODING nsr DOWNSTREAM Cyp6d2	TF binding site mE1_TFBS_inv
2R	18914446	2R_18914446_SNP [dm3] 2R_23026923_SNP [dm6]	A	G	1.826e^-5	0.863	INTRON twi & 1 other
3L	13203763	3L_13203763_INS [dm3] 3L_13210663_INS [dm6]	T	CA	1.907e^-5	0.863	UPSTREAM tRNA:CR32129 & 1 other INTERGENIC	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_sens
2R	13335866	2R_13335866_SNP [dm3] 2R_17448361_SNP [dm6]	C	T	2.104e^-5	0.863	UPSTREAM mthl4 DOWNSTREAM mthl3 INTERGENIC
2L	15053916	2L_15053916_SNP [dm3] 2L_15053916_SNP [dm6]	T	A	2.159e^-5	0.863	INTRON ck	regulatory region REDfly_CRMs
2L	18920640	2L_18920640_SNP [dm3] 2L_18920640_SNP [dm6]	T	A	2.187e^-5	0.863	INTRON ssp3	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_Kr
2L	21760063	2L_21760063_SNP [dm3] 2L_21760063_SNP [dm6]	T	A	2.209e^-5	0.863	INTRON CG1416
2L	21182979	2L_21182979_SNP [dm3] 2L_21182979_SNP [dm6]	A	T	2.264e^-5	0.863	UTR_3_PRIME Ret DOWNSTREAM Mcm10
X	19362686	X_19362686_SNP [dm3] X_19468653_SNP [dm6]	T	C	2.308e^-5	0.863	SYNONYMOUS_CODING kek5	TF binding site BDTNP1_TFBS_Mad mE1_TFBS_chinmo mE1_TFBS_HSA
3R	26070435	3R_26070435_SNP [dm3] 3R_30244713_SNP [dm6]	A	T	2.309e^-5	0.863	INTRON CG9733	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
3L	8197818	3L_8197818_SNP [dm3] 3L_8204718_SNP [dm6]	C	A	2.363e^-5	0.863	INTERGENIC
2L	7008495	2L_7008495_SNP [dm3] 2L_7008495_SNP [dm6]	G	A	2.373e^-5	0.863	START_GAINED uif UTR_5_PRIME uif INTRON uif	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_hb
2R	10328811	2R_10328811_SNP [dm3] 2R_14441306_SNP [dm6]	C	T	2.396e^-5	0.863	INTRON Oaz
2R	10324875	2R_10324875_SNP [dm3] 2R_14437370_SNP [dm6]	A	G	2.782e^-5	0.863	INTRON Oaz	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
2R	14539815	2R_14539815_SNP [dm3] 2R_18652310_SNP [dm6]	G	C	2.843e^-5	0.863	INTRON SP2637	TF binding site BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl
3R	9864852	3R_9864852_SNP [dm3] 3R_14039130_SNP [dm6]	G	A	2.909e^-5	0.863	INTERGENIC
2R	17742324	2R_17742324_SNP [dm3] 2R_21854819_SNP [dm6]	G	A	2.920e^-5	0.863	INTERGENIC	TF binding site mE1_TFBS_cad
2R	11799093	2R_11799093_SNP [dm3] 2R_15911588_SNP [dm6]	G	A	2.923e^-5	0.863	INTRON sli	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_sens
2L	2501657	2L_2501657_SNP [dm3] 2L_2501657_SNP [dm6]	G	T	2.929e^-5	0.863	INTERGENIC
2L	16238982	2L_16238982_SNP [dm3] 2L_16238982_SNP [dm6]	C	A	2.950e^-5	0.863	INTRON CG42817
3R	22745410	3R_22745410_DEL [dm3] 3R_26919688_DEL [dm6]	GGCAAAACAACACTTTG...	G	2.953e^-5	0.863	INTRON sda	TF binding site mE1_TFBS_HSA mE1_TFBS_inv
3L	8235999	3L_8235999_SNP [dm3] 3L_8242899_SNP [dm6]	C	T	3.005e^-5	0.863	INTRON Dscam4
X	13681504	X_13681504_SNP [dm3] X_13787471_SNP [dm6]	A	T	3.015e^-5	0.863	INTRON inaE	TF binding site mE1_TFBS_kn
X	13681525	X_13681525_SNP [dm3] X_13787492_SNP [dm6]	A	T	3.025e^-5	0.863	INTRON inaE	TF binding site mE1_TFBS_kn
2L	21749464	2L_21749464_SNP [dm3] 2L_21749464_SNP [dm6]	G	T	3.034e^-5	0.863	INTRON step	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	7426775	2R_7426775_SNP [dm3] 2R_11539270_SNP [dm6]	G	C	3.090e^-5	0.863	INTERGENIC
2R	11800252	2R_11800252_SNP [dm3] 2R_15912747_SNP [dm6]	G	T	3.212e^-5	0.863	INTRON sli	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Kr
3R	18628036	3R_18628036_SNP [dm3] 3R_22802314_SNP [dm6]	T	C	3.255e^-5	0.863	INTERGENIC
2L	14851473	2L_14851473_SNP [dm3] 2L_14851473_SNP [dm6]	G	T	3.362e^-5	0.863	UTR_5_PRIME CG15279	TF binding site mE1_TFBS_bab1 mE1_TFBS_cad
2R	11803074	2R_11803074_SNP [dm3] 2R_15915569_SNP [dm6]	C	A	3.433e^-5	0.863	UPSTREAM CR44373 INTRON sli	TF binding site mE1_TFBS_HSA mE1_TFBS_Trl
2L	16290107	2L_16290107_SNP [dm3] 2L_16290107_SNP [dm6]	G	A	3.466e^-5	0.863	SYNONYMOUS_CODING pkaap	TF binding site mE1_TFBS_sens
2R	14539813	2R_14539813_SNP [dm3] 2R_18652308_SNP [dm6]	C	T	3.575e^-5	0.863	INTRON SP2637	TF binding site BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl
2L	13742414	2L_13742414_SNP [dm3] 2L_13742414_SNP [dm6]	G	A	3.601e^-5	0.863	INTERGENIC
3R	9862658	3R_9862658_SNP [dm3] 3R_14036936_SNP [dm6]	G	T	3.629e^-5	0.863	UPSTREAM CG9922 INTERGENIC	TF binding site BDTNP1_TFBS_dl
2L	20855768	2L_20855768_DEL [dm3] 2L_20855768_DEL [dm6]	TT	T	3.634e^-5	0.863	INTRON twit	TF binding site mE1_TFBS_inv
2L	15017785	2L_15017785_SNP [dm3] 2L_15017785_SNP [dm6]	A	C	3.651e^-5	0.863	INTRON GABA-B-R1	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
3L	7731957	3L_7731957_SNP [dm3] 3L_7738857_SNP [dm6]	G	A	3.662e^-5	0.863	INTRON CG32373 & 1 other
2R	16477791	2R_16477791_DEL [dm3] 2R_20590286_DEL [dm6]	GAAG	G	3.691e^-5	0.863	INTRON bl	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
X	663990	X_663990_SNP [dm3] X_769957_SNP [dm6]	C	G	3.707e^-5	0.863	UTR_5_PRIME fz3 UPSTREAM fz3	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_z mE1_TFBS_D mE1_TFBS_disco mE1_TFBS_h mE1_TFBS_HSA mE1_TFBS_sens
2L	1724705	2L_1724705_DEL [dm3] 2L_1724705_DEL [dm6]	GTTG	AAA	3.713e^-5	0.863	UPSTREAM Rim2 DOWNSTREAM Eno INTERGENIC	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Ubx
2R	10860455	2R_10860455_SNP [dm3] 2R_14972950_SNP [dm6]	G	A	3.834e^-5	0.863	INTRON ckn	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2R	14539830	2R_14539830_DEL [dm3] 2R_18652325_DEL [dm6]	ACCTCGG	A	3.845e^-5	0.863	INTRON SP2637	TF binding site BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl
3R	17006857	3R_17006857_SNP [dm3] 3R_21181135_SNP [dm6]	C	A	3.914e^-5	0.863	UTR_5_PRIME SNF4Agamma INTRON SNF4Agamma	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
2L	15017880	2L_15017880_SNP [dm3] 2L_15017880_SNP [dm6]	T	C	3.995e^-5	0.863	INTRON GABA-B-R1	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
X	9949487	X_9949487_SNP [dm3] X_10055454_SNP [dm6]	A	G	4.089e^-5	0.863	UTR_3_PRIME Yp1 UPSTREAM CR45601 DOWNSTREAM CG15312
3R	15774953	3R_15774953_SNP [dm3] 3R_19949231_SNP [dm6]	T	A	4.204e^-5	0.863	DOWNSTREAM CG4783 INTRON Hs6st
X	9889544	X_9889544_SNP [dm3] X_9995511_SNP [dm6]	T	G	4.409e^-5	0.863	INTRON CG32694
3R	11810366	3R_11810366_SNP [dm3] 3R_15984644_SNP [dm6]	A	C	4.489e^-5	0.863	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_eve mE1_TFBS_HSA
2L	10907267	2L_10907267_SNP [dm3] 2L_10907267_SNP [dm6]	G	T	4.555e^-5	0.863	SYNONYMOUS_CODING CG7309
2L	11203423	2L_11203423_SNP [dm3] 2L_11203423_SNP [dm6]	G	A	4.566e^-5	0.863	START_GAINED Ca-beta UTR_5_PRIME Ca-beta	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo
3L	15336590	3L_15336590_SNP [dm3] 3L_15343490_SNP [dm6]	G	A	4.591e^-5	0.863	UTR_3_PRIME Toll-6
3L	8234419	3L_8234419_SNP [dm3] 3L_8241319_SNP [dm6]	C	A	4.603e^-5	0.863	UPSTREAM CG7213 INTRON Dscam4
2L	18027296	2L_18027296_SNP [dm3] 2L_18027296_SNP [dm6]	A	G	4.610e^-5	0.863	INTRON rdo
3R	9864583	3R_9864583_SNP [dm3] 3R_14038861_SNP [dm6]	C	T	4.624e^-5	0.863	INTERGENIC
3R	13146575	3R_13146575_SNP [dm3] 3R_17320853_SNP [dm6]	A	G	4.636e^-5	0.863	NON_SYNONYMOUS_CODING beat-IIa
2R	8968650	2R_8968650_SNP [dm3] 2R_13081145_SNP [dm6]	T	G	4.673e^-5	0.863	INTERGENIC
3R	26936012	3R_26936012_SNP [dm3] 3R_31110290_SNP [dm6]	A	T	4.835e^-5	0.863	INTERGENIC
3L	13199359	3L_13199359_INS [dm3] 3L_13206259_INS [dm6]	C	CCGCG	4.846e^-5	0.863	INTERGENIC
2R	14539824	2R_14539824_SNP [dm3] 2R_18652319_SNP [dm6]	T	A	4.861e^-5	0.863	INTRON SP2637	TF binding site BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl
2R	2894462	2R_2894462_SNP [dm3] 2R_7006957_SNP [dm6]	T	G	4.898e^-5	0.863	DOWNSTREAM CG30160 INTRON Tsp42Ec
2R	4144294	2R_4144294_SNP [dm3] 2R_8256789_SNP [dm6]	A	C	5.097e^-5	0.863	UTR_3_PRIME CG14760	TF binding site mE1_TFBS_cad
3L	7993329	3L_7993329_SNP [dm3] 3L_8000229_SNP [dm6]	T	G	5.139e^-5	0.863	INTRON nmo
X	7987106	X_7987106_SNP [dm3] X_8093073_SNP [dm6]	G	A	5.381e^-5	0.863	UPSTREAM Ubc-E2H INTRON Ubc-E2H	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_sens mE1_TFBS_Trl
2L	12285769	2L_12285769_SNP [dm3] 2L_12285769_SNP [dm6]	G	A	5.383e^-5	0.863	INTRON aret
X	16322009	X_16322009_SNP [dm3] X_16427976_SNP [dm6]	C	A	5.579e^-5	0.863	INTRON hang	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi mE1_TFBS_disco mE1_TFBS_h mE1_TFBS_HSA mE1_TFBS_jumu mE1_TFBS_kn mE1_TFBS_run mE1_TFBS_zfh1
2L	12175947	2L_12175947_SNP [dm3] 2L_12175947_SNP [dm6]	C	A	5.650e^-5	0.863	INTRON aret & 1 other	TF binding site mE1_TFBS_HSA
2L	9431122	2L_9431122_SNP [dm3] 2L_9431122_SNP [dm6]	C	G	5.815e^-5	0.863	UPSTREAM scat & 1 other INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	2642296	2L_2642296_SNP [dm3] 2L_2642296_SNP [dm6]	A	G	5.856e^-5	0.863	INTERGENIC
2L	10701703	2L_10701703_SNP [dm3] 2L_10701703_SNP [dm6]	T	A	5.950e^-5	0.863	UPSTREAM Lip1 DOWNSTREAM Lip2 INTERGENIC	regulatory region REDfly_CRMs
3R	21144454	3R_21144454_SNP [dm3] 3R_25318732_SNP [dm6]	C	T	5.979e^-5	0.863	SYNONYMOUS_CODING CG10560 UPSTREAM CG10553
2L	12175942	2L_12175942_SNP [dm3] 2L_12175942_SNP [dm6]	T	G	5.981e^-5	0.863	INTRON aret & 1 other	TF binding site mE1_TFBS_HSA

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By genomic position
Variant impact
Gene name

Food_Intake_MPH phenotype

Phenotype distribution and association to known covariates

QQplot

Manhattan plot

GWAS results