DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=3.187e^-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test
No significant result.

Kruskal-Wallis test
No significant result.

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

150 significant hits at p-value < 0.001.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
2L	3241671	2L_3241671_SNP [dm3] 2L_3241671_SNP [dm6]	G	T	2.906e^-6	0.609	INTERGENIC	TF binding site mE1_TFBS_HSA mE1_TFBS_sbb
X	6968535	X_6968535_SNP [dm3] X_7074502_SNP [dm6]	T	A	3.362e^-5	0.609	DOWNSTREAM Sxl INTERGENIC	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
3L	1165730	3L_1165730_SNP [dm3] 3L_1165730_SNP [dm6]	A	G	3.744e^-5	0.609	INTRON bab2	regulatory region REDfly_CRMs TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi
3R	27837592	3R_27837592_SNP [dm3] 3R_32011870_SNP [dm6]	A	C	6.472e^-5	0.609	UPSTREAM CR45556 INTRON heph	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi
3R	27851585	3R_27851585_SNP [dm3] 3R_32025863_SNP [dm6]	C	A	6.472e^-5	0.609	EXON CR45557
3L	16949799	3L_16949799_SNP [dm3] 3L_16956699_SNP [dm6]	C	A	1.137e^-4	0.609	UPSTREAM Nc73EF INTRON Nc73EF	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
3L	7762326	3L_7762326_SNP [dm3] 3L_7769226_SNP [dm6]	A	T	1.374e^-4	0.609	UPSTREAM CG32371 INTRON Clk
X	5151778	X_5151778_SNP [dm3] X_5257745_SNP [dm6]	A	C	1.522e^-4	0.609	INTERGENIC
3R	7542618	3R_7542618_SNP [dm3] 3R_11716896_SNP [dm6]	C	T	1.726e^-4	0.609	INTERGENIC	TF binding site BDTNP1_TFBS_twi
3R	17632572	3R_17632572_SNP [dm3] 3R_21806850_SNP [dm6]	A	G	2.134e^-4	0.609	INTRON CASK
2R	13772584	2R_13772584_SNP [dm3] 2R_17885079_SNP [dm6]	G	A	2.954e^-4	0.609	INTRON Elk
3R	21184268	3R_21184268_SNP [dm3] 3R_25358546_SNP [dm6]	T	A	3.395e^-4	0.609	INTRON Fur1 & 1 other
3R	21851693	3R_21851693_SNP [dm3] 3R_26025971_SNP [dm6]	T	C	3.395e^-4	0.609	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_twi
2L	19580464	2L_19580464_SNP [dm3] 2L_19580464_SNP [dm6]	C	T	3.902e^-4	0.609	UPSTREAM CG10268 DOWNSTREAM Hakai INTERGENIC	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_cad mE1_TFBS_HSA
2L	19878794	2L_19878794_SNP [dm3] 2L_19878794_SNP [dm6]	G	C	3.902e^-4	0.609	INTRON sick
2L	19885784	2L_19885784_SNP [dm3] 2L_19885784_SNP [dm6]	C	A	3.902e^-4	0.609	INTRON sick	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
2L	19886157	2L_19886157_SNP [dm3] 2L_19886157_SNP [dm6]	A	C	3.902e^-4	0.609	INTRON sick
2L	19887811	2L_19887811_SNP [dm3] 2L_19887811_SNP [dm6]	C	T	3.902e^-4	0.609	INTRON sick	TF binding site BDTNP1_TFBS_dl mE1_TFBS_bab1 mE1_TFBS_cad mE1_TFBS_D mE1_TFBS_HSA
2L	19892572	2L_19892572_SNP [dm3] 2L_19892572_SNP [dm6]	C	A	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892592	2L_19892592_SNP [dm3] 2L_19892592_SNP [dm6]	A	T	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892614	2L_19892614_SNP [dm3] 2L_19892614_SNP [dm6]	G	A	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892637	2L_19892637_SNP [dm3] 2L_19892637_SNP [dm6]	G	T	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892638	2L_19892638_SNP [dm3] 2L_19892638_SNP [dm6]	A	T	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892641	2L_19892641_SNP [dm3] 2L_19892641_SNP [dm6]	G	A	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19892711	2L_19892711_SNP [dm3] 2L_19892711_SNP [dm6]	C	T	3.902e^-4	0.609	UPSTREAM CG10481 INTRON sick	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	19895952	2L_19895952_SNP [dm3] 2L_19895952_SNP [dm6]	C	A	3.902e^-4	0.609	UPSTREAM sick INTRON sick	silencer mE1_HDAC_PRE
2L	19896821	2L_19896821_SNP [dm3] 2L_19896821_SNP [dm6]	C	T	3.902e^-4	0.609	INTRON sick
2L	19897231	2L_19897231_SNP [dm3] 2L_19897231_SNP [dm6]	T	G	3.902e^-4	0.609	INTRON sick	TF binding site mE1_TFBS_HSA
2L	19908503	2L_19908503_SNP [dm3] 2L_19908503_SNP [dm6]	C	T	3.902e^-4	0.609	INTRON sick
2L	19915451	2L_19915451_SNP [dm3] 2L_19915451_SNP [dm6]	A	T	3.902e^-4	0.609	INTRON sick	TF binding site mE1_TFBS_bab1 mE1_TFBS_HSA
3L	1114389	3L_1114389_SNP [dm3] 3L_1114389_SNP [dm6]	T	C	3.902e^-4	0.609	INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3L	1114403	3L_1114403_SNP [dm3] 3L_1114403_SNP [dm6]	T	A	3.902e^-4	0.609	INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3L	7129112	3L_7129112_INS [dm3] 3L_7136012_INS [dm6]	G	GAAGAAGG	3.902e^-4	0.609	INTRON melt	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	7129114	3L_7129114_SNP [dm3] 3L_7136014_SNP [dm6]	G	A	3.902e^-4	0.609	INTRON melt	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	7129119	3L_7129119_SNP [dm3] 3L_7136019_SNP [dm6]	T	G	3.902e^-4	0.609	INTRON melt	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	7129120	3L_7129120_SNP [dm3] 3L_7136020_SNP [dm6]	A	G	3.902e^-4	0.609	INTRON melt	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	8315942	3L_8315942_INS [dm3] 3L_8322842_INS [dm6]	C	CC	3.902e^-4	0.609	DOWNSTREAM CG13670 INTERGENIC
3R	11950491	3R_11950491_SNP [dm3] 3R_16124769_SNP [dm6]	T	C	3.902e^-4	0.609	INTRON Sb
3R	15031323	3R_15031323_SNP [dm3] 3R_19205601_SNP [dm6]	C	G	3.902e^-4	0.609	INTERGENIC
3R	16918073	3R_16918073_SNP [dm3] 3R_21092351_SNP [dm6]	C	T	3.902e^-4	0.609	INTRON RhoGAP93B & 1 other
3R	16918110	3R_16918110_SNP [dm3] 3R_21092388_SNP [dm6]	T	G	3.902e^-4	0.609	INTRON RhoGAP93B & 1 other
3R	16918125	3R_16918125_SNP [dm3] 3R_21092403_SNP [dm6]	C	A	3.902e^-4	0.609	INTRON RhoGAP93B & 1 other
3R	17594972	3R_17594972_SNP [dm3] 3R_21769250_SNP [dm6]	C	A	3.902e^-4	0.609	NON_SYNONYMOUS_CODING CG42335 UPSTREAM Burs
3R	22483323	3R_22483323_SNP [dm3] 3R_26657601_SNP [dm6]	C	T	3.902e^-4	0.609	DOWNSTREAM Tb INTRON beat-VII
3R	24667581	3R_24667581_SNP [dm3] 3R_28841859_SNP [dm6]	T	C	3.902e^-4	0.609	INTRON Apc	TF binding site BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	27498507	3R_27498507_SNP [dm3] 3R_31672785_SNP [dm6]	C	A	3.902e^-4	0.609	INTRON CG1815
3R	27821208	3R_27821208_SNP [dm3] 3R_31995486_SNP [dm6]	T	C	3.902e^-4	0.609	INTRON heph
3R	27831989	3R_27831989_SNP [dm3] 3R_32006267_SNP [dm6]	A	T	3.902e^-4	0.609	INTRON heph	transposable element FlyBase
3R	27834838	3R_27834838_SNP [dm3] 3R_32009116_SNP [dm6]	A	G	3.902e^-4	0.609	INTRON heph	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3R	27835886	3R_27835886_SNP [dm3] 3R_32010164_SNP [dm6]	T	G	3.902e^-4	0.609	INTRON heph	TF binding site BDTNP1_TFBS_prd mE1_TFBS_HSA
3R	27839451	3R_27839451_SNP [dm3] 3R_32013729_SNP [dm6]	T	C	3.902e^-4	0.609	DOWNSTREAM CR45556 INTRON heph	TF binding site BDTNP1_TFBS_twi
3R	27842893	3R_27842893_SNP [dm3] 3R_32017171_SNP [dm6]	A	T	3.902e^-4	0.609	EXON CR45557
3R	27857762	3R_27857762_SNP [dm3] 3R_32032040_SNP [dm6]	G	A	3.902e^-4	0.609	INTERGENIC
3R	27862055	3R_27862055_SNP [dm3] 3R_32036333_SNP [dm6]	A	T	3.902e^-4	0.609	INTERGENIC
3R	27866377	3R_27866377_SNP [dm3] 3R_32040655_SNP [dm6]	G	A	3.902e^-4	0.609	DOWNSTREAM CG2053 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	27866382	3R_27866382_SNP [dm3] 3R_32040660_SNP [dm6]	A	G	3.902e^-4	0.609	DOWNSTREAM CG2053 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	27871469	3R_27871469_SNP [dm3] 3R_32045747_SNP [dm6]	T	A	3.902e^-4	0.609	UTR_3_PRIME krz
3R	27878919	3R_27878919_SNP [dm3] 3R_32053197_SNP [dm6]	T	G	3.902e^-4	0.609	INTRON mod	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	27889774	3R_27889774_INS [dm3] 3R_32064052_INS [dm6]	A	AAAGCTGTATTAA...	3.902e^-4	0.609	INTRON Map205
X	5475827	X_5475827_SNP [dm3] X_5581794_SNP [dm6]	G	A	3.902e^-4	0.609	INTERGENIC
2R	14279047	2R_14279047_SNP [dm3] 2R_18391542_SNP [dm6]	C	A	4.428e^-4	0.609	UPSTREAM CG15068 INTERGENIC	TF binding site BDTNP1_TFBS_twi
3L	11654713	3L_11654713_SNP [dm3] 3L_11661613_SNP [dm6]	T	C	4.866e^-4	0.609	INTRON CG32085
3L	2559071	3L_2559071_SNP [dm3] 3L_2559071_SNP [dm6]	A	G	4.866e^-4	0.609	INTRON msn
3L	9478969	3L_9478969_SNP [dm3] 3L_9485869_SNP [dm6]	A	C	4.866e^-4	0.609	UTR_3_PRIME Jarid2 DOWNSTREAM pall	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi
3L	9880732	3L_9880732_SNP [dm3] 3L_9887632_SNP [dm6]	A	G	4.866e^-4	0.609	SYNONYMOUS_CODING Taf2	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
3R	21183244	3R_21183244_SNP [dm3] 3R_25357522_SNP [dm6]	C	T	4.866e^-4	0.609	UPSTREAM CG11913 INTRON Fur1
3R	21183268	3R_21183268_SNP [dm3] 3R_25357546_SNP [dm6]	T	C	4.866e^-4	0.609	UPSTREAM CG11913 INTRON Fur1
3R	21183271	3R_21183271_SNP [dm3] 3R_25357549_SNP [dm6]	G	A	4.866e^-4	0.609	UPSTREAM CG11913 INTRON Fur1
3R	21184060	3R_21184060_SNP [dm3] 3R_25358338_SNP [dm6]	C	T	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1
3R	21184068	3R_21184068_SNP [dm3] 3R_25358346_SNP [dm6]	T	C	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1
3R	21184656	3R_21184656_SNP [dm3] 3R_25358934_SNP [dm6]	C	T	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1
3R	21184799	3R_21184799_SNP [dm3] 3R_25359077_SNP [dm6]	G	C	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1	TF binding site mE1_TFBS_sens
3R	21184835	3R_21184835_SNP [dm3] 3R_25359113_SNP [dm6]	G	T	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1	TF binding site mE1_TFBS_sens
3R	21184925	3R_21184925_SNP [dm3] 3R_25359203_SNP [dm6]	C	T	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
3R	21185636	3R_21185636_SNP [dm3] 3R_25359914_SNP [dm6]	T	C	4.866e^-4	0.609	SYNONYMOUS_CODING CG11913 INTRON Fur1
3R	21185872	3R_21185872_SNP [dm3] 3R_25360150_SNP [dm6]	A	T	4.866e^-4	0.609	DOWNSTREAM CG11913 INTRON Fur1
3R	21185873	3R_21185873_SNP [dm3] 3R_25360151_SNP [dm6]	A	G	4.866e^-4	0.609	DOWNSTREAM CG11913 INTRON Fur1
3R	21185901	3R_21185901_SNP [dm3] 3R_25360179_SNP [dm6]	T	A	4.866e^-4	0.609	DOWNSTREAM CG11913 INTRON Fur1
3R	22311073	3R_22311073_SNP [dm3] 3R_26485351_SNP [dm6]	A	T	4.866e^-4	0.609	INTRON plum
3R	22311076	3R_22311076_SNP [dm3] 3R_26485354_SNP [dm6]	C	A	4.866e^-4	0.609	INTRON plum
3R	23292455	3R_23292455_SNP [dm3] 3R_27466733_SNP [dm6]	G	A	4.866e^-4	0.609	SYNONYMOUS_CODING CG13978	TF binding site mE1_TFBS_inv
3R	24091952	3R_24091952_SNP [dm3] 3R_28266230_SNP [dm6]	C	T	4.866e^-4	0.609	INTERGENIC
3R	27542394	3R_27542394_SNP [dm3] 3R_31716672_SNP [dm6]	A	C	4.866e^-4	0.609	INTRON ttk	TF binding site mE1_TFBS_inv
3R	27542493	3R_27542493_SNP [dm3] 3R_31716771_SNP [dm6]	G	C	4.866e^-4	0.609	INTRON ttk	TF binding site mE1_TFBS_HSA mE1_TFBS_inv
3R	27542968	3R_27542968_SNP [dm3] 3R_31717246_SNP [dm6]	A	G	4.866e^-4	0.609	INTRON ttk	TF binding site mE1_TFBS_inv
3R	27552684	3R_27552684_SNP [dm3] 3R_31726962_SNP [dm6]	G	T	4.866e^-4	0.609	INTRON ttk	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_inv mE1_TFBS_Trl
3R	27552790	3R_27552790_SNP [dm3] 3R_31727068_SNP [dm6]	G	T	4.866e^-4	0.609	INTRON ttk	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_inv
3R	27554581	3R_27554581_SNP [dm3] 3R_31728859_SNP [dm6]	T	C	4.866e^-4	0.609	INTRON ttk	TF binding site mE1_TFBS_sens
3R	27556015	3R_27556015_SNP [dm3] 3R_31730293_SNP [dm6]	A	C	4.866e^-4	0.609	SYNONYMOUS_CODING ttk INTRON ttk	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
X	20746349	X_20746349_SNP [dm3] X_20875322_SNP [dm6]	A	G	4.866e^-4	0.609	DOWNSTREAM CR11235 INTRON shakB
X	2180535	X_2180535_SNP [dm3] X_2286502_SNP [dm6]	A	G	4.866e^-4	0.609	INTRON CG2865	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
X	8634517	X_8634517_SNP [dm3] X_8740484_SNP [dm6]	A	G	4.866e^-4	0.609	INTERGENIC
3R	27866015	3R_27866015_INS [dm3] 3R_32040293_INS [dm6]	A	AA	4.938e^-4	0.609	DOWNSTREAM CG2053 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi
3R	21851804	3R_21851804_SNP [dm3] 3R_26026082_SNP [dm6]	G	C	5.119e^-4	0.609	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi
3L	2529894	3L_2529894_SNP [dm3] 3L_2529894_SNP [dm6]	T	A	5.325e^-4	0.609	INTRON Spn	TF binding site BDTNP1_TFBS_twi mE1_TFBS_D mE1_TFBS_HSA
3L	9897135	3L_9897135_SNP [dm3] 3L_9904035_SNP [dm6]	T	C	5.325e^-4	0.609	INTERGENIC
X	18978027	X_18978027_SNP [dm3] X_19083994_SNP [dm6]	C	T	5.325e^-4	0.609	UPSTREAM CG7423 EXON CR45503
3R	21183189	3R_21183189_SNP [dm3] 3R_25357467_SNP [dm6]	A	G	6.327e^-4	0.609	SYNONYMOUS_CODING Fur1 UPSTREAM CG11913	TF binding site mE1_TFBS_chinmo
3L	8078322	3L_8078322_MNP [dm3] 3L_8085222_MNP [dm6]	CAA	TGG	6.355e^-4	0.609	INTRON Ect4
3R	21182889	3R_21182889_SNP [dm3] 3R_25357167_SNP [dm6]	A	T	6.784e^-4	0.609	SYNONYMOUS_CODING Fur1	TF binding site mE1_TFBS_chinmo

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By genomic position
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lifespan phenotype

Phenotype distribution and association to known covariates

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GWAS results