DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=6.775e^-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test
No significant result.

Kruskal-Wallis test
No significant result.

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

2028 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
3R	23254918	3R_23254918_SNP [dm3] 3R_27429196_SNP [dm6]	A	G	3.159e^-7	0.592	INTRON side
2R	1099034	2R_1099034_SNP [dm3] 2R_5211529_SNP [dm6]	A	T	1.488e^-6	0.598	INTRON Nipped-A
3R	23254891	3R_23254891_SNP [dm3] 3R_27429169_SNP [dm6]	T	A	2.110e^-6	0.598	INTRON side
2R	1099224	2R_1099224_SNP [dm3] 2R_5211719_SNP [dm6]	A	T	2.287e^-6	0.598	INTRON Nipped-A	transposable element FlyBase
3R	14993307	3R_14993307_SNP [dm3] 3R_19167585_SNP [dm6]	C	G	2.416e^-6	0.598	INTRON sqz
3R	14993376	3R_14993376_SNP [dm3] 3R_19167654_SNP [dm6]	C	T	2.416e^-6	0.598	INTRON sqz	TF binding site mE1_TFBS_cad
X	14395121	X_14395121_SNP [dm3] X_14501088_SNP [dm6]	A	C	2.815e^-6	0.598	INTERGENIC
3L	13128699	3L_13128699_INS [dm3] 3L_13135599_INS [dm6]	T	TAGCA	2.969e^-6	0.598	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	13128705	3L_13128705_INS [dm3] 3L_13135605_INS [dm6]	A	AGCATATAT	2.969e^-6	0.598	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	2561270	3L_2561270_SNP [dm3] 3L_2561270_SNP [dm6]	A	C	3.279e^-6	0.598	INTRON msn
3L	13128758	3L_13128758_SNP [dm3] 3L_13135658_SNP [dm6]	A	T	3.509e^-6	0.598	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	15003212	3R_15003212_SNP [dm3] 3R_19177490_SNP [dm6]	G	A	3.983e^-6	0.622	NON_SYNONYMOUS_CODING CG14282 DOWNSTREAM CG5555	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
2R	12896910	2R_12896910_INS [dm3] 2R_17009405_INS [dm6]	C	AGGCCG	4.438e^-6	0.628	INTRON Ehbp1	TF binding site mE1_TFBS_cad
3L	13128702	3L_13128702_SNP [dm3] 3L_13135602_SNP [dm6]	A	T	5.557e^-6	0.628	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	9806937	2R_9806937_SNP [dm3] 2R_13919432_SNP [dm6]	A	G	5.794e^-6	0.628	INTRON shot	TF binding site mE1_TFBS_Trl
2R	9145921	2R_9145921_SNP [dm3] 2R_13258416_SNP [dm6]	G	C	5.860e^-6	0.628	NON_SYNONYMOUS_CODING CG10799 DOWNSTREAM CG4716
2R	16309045	2R_16309045_SNP [dm3] 2R_20421540_SNP [dm6]	C	G	6.185e^-6	0.628	INTERGENIC
2L	3104072	2L_3104072_SNP [dm3] 2L_3104072_SNP [dm6]	A	C	6.603e^-6	0.628	INTRON toc
3L	2124997	3L_2124997_DEL [dm3] 3L_2124997_DEL [dm6]	AA	A	6.847e^-6	0.628	INTRON zormin
2R	16309049	2R_16309049_SNP [dm3] 2R_20421544_SNP [dm6]	A	T	6.980e^-6	0.628	INTERGENIC
X	20411243	X_20411243_SNP [dm3] X_20540216_SNP [dm6]	C	T	7.280e^-6	0.628	INTRON RunxB	TF binding site mE1_TFBS_inv
3L	13128712	3L_13128712_SNP [dm3] 3L_13135612_SNP [dm6]	T	C	7.376e^-6	0.628	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	9990835	2L_9990835_DEL [dm3] 2L_9990835_DEL [dm6]	AGGTATGA	A	7.835e^-6	0.629	INTRON bib	regulatory region REDfly_CRMs TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi
2R	11245361	2R_11245361_SNP [dm3] 2R_15357856_SNP [dm6]	A	G	8.422e^-6	0.629	INTRON unc-5	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_inv
2L	3498569	2L_3498569_SNP [dm3] 2L_3498569_SNP [dm6]	C	G	8.823e^-6	0.629	INTRON tim
2L	12512137	2L_12512137_SNP [dm3] 2L_12512137_SNP [dm6]	G	C	9.594e^-6	0.629	INTRON bun
2L	2737863	2L_2737863_SNP [dm3] 2L_2737863_SNP [dm6]	C	T	9.824e^-6	0.629	SYNONYMOUS_CODING CG31689 DOWNSTREAM mir-4914
3L	13128681	3L_13128681_SNP [dm3] 3L_13135581_SNP [dm6]	A	G	1.041e^-5	0.629	UPSTREAM CG33262 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna mE1_TFBS_HSA
X	19324053	X_19324053_SNP [dm3] X_19430020_SNP [dm6]	T	C	1.070e^-5	0.629	INTRON kek5
2R	6788862	2R_6788862_SNP [dm3] 2R_10901357_SNP [dm6]	G	T	1.077e^-5	0.629	INTERGENIC
3R	20604050	3R_20604050_SNP [dm3] 3R_24778328_SNP [dm6]	T	C	1.151e^-5	0.629	INTRON CG42331
3R	22166339	3R_22166339_SNP [dm3] 3R_26340617_SNP [dm6]	T	G	1.253e^-5	0.629	INTRON CG33970
2R	16929277	2R_16929277_SNP [dm3] 2R_21041772_SNP [dm6]	T	A	1.280e^-5	0.629	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_HSA
X	4732432	X_4732432_DEL [dm3] X_4838399_DEL [dm6]	ATACC	T	1.373e^-5	0.629	INTERGENIC
X	4732439	X_4732439_SNP [dm3] X_4838406_SNP [dm6]	A	T	1.373e^-5	0.629	INTERGENIC
2L	1848969	2L_1848969_SNP [dm3] 2L_1848969_SNP [dm6]	T	G	1.394e^-5	0.629	INTRON wry
3R	21455243	3R_21455243_SNP [dm3] 3R_25629521_SNP [dm6]	G	T	1.414e^-5	0.629	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
X	20411217	X_20411217_SNP [dm3] X_20540190_SNP [dm6]	A	G	1.447e^-5	0.629	INTRON RunxB	TF binding site mE1_TFBS_inv
3R	27165408	3R_27165408_SNP [dm3] 3R_31339686_SNP [dm6]	C	G	1.454e^-5	0.629	INTRON CG34347
3R	25217332	3R_25217332_DEL [dm3] 3R_29391610_DEL [dm6]	TT	T	1.496e^-5	0.629	INTRON Ptp99A
2L	3104089	2L_3104089_SNP [dm3] 2L_3104089_SNP [dm6]	G	A	1.529e^-5	0.629	INTRON toc
3R	14983084	3R_14983084_SNP [dm3] 3R_19157362_SNP [dm6]	G	A	1.538e^-5	0.629	UTR_5_PRIME nos UPSTREAM CG11779 INTRON CG11779	regulatory region REDfly_CRMs TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Stat92E
2L	3674083	2L_3674083_SNP [dm3] 2L_3674083_SNP [dm6]	T	C	1.544e^-5	0.629	INTRON CG34340
2R	12967499	2R_12967499_SNP [dm3] 2R_17079994_SNP [dm6]	T	G	1.556e^-5	0.629	INTRON CG30460
2L	11599129	2L_11599129_SNP [dm3] 2L_11599129_SNP [dm6]	T	A	1.556e^-5	0.629	INTRON kek2
2R	18728650	2R_18728650_SNP [dm3] 2R_22841127_SNP [dm6]	G	A	1.560e^-5	0.629	SYNONYMOUS_CODING CG9826	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_sens
2L	3104090	2L_3104090_SNP [dm3] 2L_3104090_SNP [dm6]	C	G	1.577e^-5	0.629	INTRON toc
3R	14173584	3R_14173584_SNP [dm3] 3R_18347862_SNP [dm6]	A	T	1.816e^-5	0.709	INTRON CG15803
2L	9726606	2L_9726606_SNP [dm3] 2L_9726606_SNP [dm6]	C	T	1.864e^-5	0.713	INTRON Nckx30C
3R	18556029	3R_18556029_SNP [dm3] 3R_22730307_SNP [dm6]	A	C	1.947e^-5	0.723	UTR_3_PRIME CG45049
2L	3284659	2L_3284659_SNP [dm3] 2L_3284659_SNP [dm6]	A	T	1.968e^-5	0.723	INTERGENIC
3L	2567886	3L_2567886_SNP [dm3] 3L_2567886_SNP [dm6]	G	A	2.072e^-5	0.725	INTRON msn	regulatory region REDfly_CRMs
3L	15017005	3L_15017005_SNP [dm3] 3L_15023905_SNP [dm6]	C	T	2.085e^-5	0.725	UTR_3_PRIME CG32148 INTRON Sytbeta
3R	17661350	3R_17661350_SNP [dm3] 3R_21835628_SNP [dm6]	T	G	2.094e^-5	0.725	INTERGENIC
3R	20593915	3R_20593915_SNP [dm3] 3R_24768193_SNP [dm6]	A	G	2.128e^-5	0.725	EXON CR45650	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_z mE1_TFBS_HSA mE1_TFBS_Trl
2R	18025945	2R_18025945_SNP [dm3] 2R_22138440_SNP [dm6]	G	A	2.245e^-5	0.742	UPSTREAM CG11269 INTRON a
X	10149971	X_10149971_SNP [dm3] X_10255938_SNP [dm6]	G	A	2.369e^-5	0.742	UPSTREAM CR43959 INTRON Hk
3L	2561254	3L_2561254_SNP [dm3] 3L_2561254_SNP [dm6]	G	A	2.446e^-5	0.742	INTRON msn
2R	12964987	2R_12964987_SNP [dm3] 2R_17077482_SNP [dm6]	C	G	2.448e^-5	0.742	INTRON CG30460
3L	7921507	3L_7921507_SNP [dm3] 3L_7928407_SNP [dm6]	T	A	2.466e^-5	0.742	SPLICE_SITE_REGION syd INTRON syd	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_sens
2L	4901956	2L_4901956_SNP [dm3] 2L_4901956_SNP [dm6]	A	G	2.507e^-5	0.742	INTRON CG3036	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
X	12181760	X_12181760_SNP [dm3] X_12287727_SNP [dm6]	A	G	2.544e^-5	0.742	INTRON Ten-a
2R	16517402	2R_16517402_SNP [dm3] 2R_20629897_SNP [dm6]	G	A	2.549e^-5	0.742	SYNONYMOUS_CODING Rcd6	TF binding site mE1_TFBS_chinmo
X	5224574	X_5224574_SNP [dm3] X_5330541_SNP [dm6]	C	A	2.691e^-5	0.742	NON_SYNONYMOUS_CODING XRCC1	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA mE1_TFBS_sens
3R	21973466	3R_21973466_SNP [dm3] 3R_26147744_SNP [dm6]	T	G	2.748e^-5	0.742	INTERGENIC
3R	25704774	3R_25704774_SNP [dm3] 3R_29879052_SNP [dm6]	G	A	2.748e^-5	0.742	SYNONYMOUS_CODING CG31038	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
2L	8044099	2L_8044099_SNP [dm3] 2L_8044099_SNP [dm6]	G	T	2.783e^-5	0.742	INTRON CG7466	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
2R	14558686	2R_14558686_SNP [dm3] 2R_18671181_SNP [dm6]	T	C	2.784e^-5	0.742	INTRON edl	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi
2L	1849007	2L_1849007_SNP [dm3] 2L_1849007_SNP [dm6]	T	C	2.874e^-5	0.742	INTRON wry
3R	14173589	3R_14173589_SNP [dm3] 3R_18347867_SNP [dm6]	T	C	2.930e^-5	0.742	INTRON CG15803
2R	8579289	2R_8579289_SNP [dm3] 2R_12691784_SNP [dm6]	A	T	2.953e^-5	0.742	SPLICE_SITE_REGION CG8768 UPSTREAM Obp49a INTRON CG8768	TF binding site mE1_TFBS_sens
3R	19310439	3R_19310439_SNP [dm3] 3R_23484717_SNP [dm6]	C	T	2.963e^-5	0.742	SYNONYMOUS_CODING Ir94g UPSTREAM CR44324	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
3R	14173629	3R_14173629_SNP [dm3] 3R_18347907_SNP [dm6]	A	T	3.042e^-5	0.742	INTRON CG15803
X	9487660	X_9487660_SNP [dm3] X_9593627_SNP [dm6]	C	T	3.069e^-5	0.742	INTERGENIC
2L	11883718	2L_11883718_SNP [dm3] 2L_11883718_SNP [dm6]	C	T	3.085e^-5	0.742	INTRON Pde1c
2L	9990848	2L_9990848_INS [dm3] 2L_9990848_INS [dm6]	T	TT	3.094e^-5	0.742	INTRON bib	regulatory region REDfly_CRMs TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_slp1 BDTNP1_TFBS_twi
3R	19310415	3R_19310415_SNP [dm3] 3R_23484693_SNP [dm6]	C	T	3.151e^-5	0.742	SYNONYMOUS_CODING Ir94g UPSTREAM CR44324	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
3L	20902093	3L_20902093_SNP [dm3] 3L_20908993_SNP [dm6]	T	A	3.177e^-5	0.742	INTERGENIC
2L	13632652	2L_13632652_SNP [dm3] 2L_13632652_SNP [dm6]	T	A	3.234e^-5	0.742	DOWNSTREAM CR43410 INTRON kuz
3R	9879534	3R_9879534_DEL [dm3] 3R_14053812_DEL [dm6]	CC	C	3.243e^-5	0.742	INTERGENIC
3L	10155969	3L_10155969_SNP [dm3] 3L_10162869_SNP [dm6]	T	A	3.293e^-5	0.742	INTRON dpr10
3L	10155802	3L_10155802_SNP [dm3] 3L_10162702_SNP [dm6]	G	A	3.463e^-5	0.742	INTRON dpr10
3L	2567863	3L_2567863_SNP [dm3] 3L_2567863_SNP [dm6]	C	A	3.518e^-5	0.742	INTRON msn	regulatory region REDfly_CRMs
2R	7293754	2R_7293754_SNP [dm3] 2R_11406249_SNP [dm6]	A	T	3.540e^-5	0.742	SYNONYMOUS_CODING CG7759 UPSTREAM tRNA:CR45107
3L	2567870	3L_2567870_SNP [dm3] 3L_2567870_SNP [dm6]	T	A	3.599e^-5	0.742	INTRON msn	regulatory region REDfly_CRMs
3L	1824031	3L_1824031_SNP [dm3] 3L_1824031_SNP [dm6]	C	A	3.600e^-5	0.742	DOWNSTREAM Cpr62Ba INTERGENIC
2R	20507919	2R_20507919_SNP [dm3] 2R_24620396_SNP [dm6]	T	A	3.744e^-5	0.742	INTRON CG13594	TF binding site mE1_TFBS_chinmo
3L	2567893	3L_2567893_SNP [dm3] 3L_2567893_SNP [dm6]	A	G	3.750e^-5	0.742	INTRON msn	regulatory region REDfly_CRMs
3R	27189959	3R_27189959_SNP [dm3] 3R_31364237_SNP [dm6]	C	A	3.780e^-5	0.742	INTRON CG34347
3L	2561124	3L_2561124_SNP [dm3] 3L_2561124_SNP [dm6]	T	A	3.788e^-5	0.742	INTRON msn
2L	916066	2L_916066_SNP [dm3] 2L_916066_SNP [dm6]	G	C	3.796e^-5	0.742	SYNONYMOUS_CODING GluRIIC	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo
X	10787484	X_10787484_DEL [dm3] X_10893451_DEL [dm6]	ATAATGTT	A	3.880e^-5	0.742	DOWNSTREAM CR45617 INTRON CR44524
3R	11709513	3R_11709513_SNP [dm3] 3R_15883791_SNP [dm6]	T	C	3.907e^-5	0.742	INTERGENIC
3L	20923190	3L_20923190_SNP [dm3] 3L_20930090_SNP [dm6]	C	T	3.922e^-5	0.742	DOWNSTREAM CG10589 INTRON fng
2L	903827	2L_903827_SNP [dm3] 2L_903827_SNP [dm6]	C	T	3.923e^-5	0.742	UPSTREAM CR45261 INTERGENIC
2R	11203292	2R_11203292_SNP [dm3] 2R_15315787_SNP [dm6]	C	T	3.988e^-5	0.742	NON_SYNONYMOUS_CODING mus210
2R	13397188	2R_13397188_INS [dm3] 2R_17509683_INS [dm6]	T	TT	3.998e^-5	0.742	UTR_5_PRIME CG34193 UPSTREAM CG34193
3R	12924178	3R_12924178_SNP [dm3] 3R_17098456_SNP [dm6]	T	C	4.000e^-5	0.742	INTRON cher
X	7518282	X_7518282_SNP [dm3] X_7624249_SNP [dm6]	C	G	4.011e^-5	0.742	INTRON ct
3R	13385559	3R_13385559_SNP [dm3] 3R_17559837_SNP [dm6]	A	G	4.127e^-5	0.742	SYNONYMOUS_CODING Hmx	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA

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By genomic position
Variant impact
Gene name

mn_Triglyceride_Pool phenotype

Phenotype distribution and association to known covariates

QQplot

Manhattan plot

GWAS results