DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=2.937e^-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test

Covariate	p-value	Significance
In_2L_t	0.02276
In_3R_Mo	0.04939

Kruskal-Wallis test
No significant result.

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

2096 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
3L	6941278	3L_6941278_SNP [dm3] 3L_6948178_SNP [dm6]	C	T	3.223e^-7	0.242	INTRON tow
3L	8165601	3L_8165601_SNP [dm3] 3L_8172501_SNP [dm6]	C	T	3.672e^-7	0.242	INTRON RecQ4	TF binding site BDTNP1_TFBS_twi
3L	8165585	3L_8165585_SNP [dm3] 3L_8172485_SNP [dm6]	G	A	4.291e^-7	0.242	INTRON RecQ4	TF binding site BDTNP1_TFBS_twi
3L	14359613	3L_14359613_SNP [dm3] 3L_14366513_SNP [dm6]	G	A	7.922e^-7	0.242	INTRON fz	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_sbb
3L	6941284	3L_6941284_SNP [dm3] 3L_6948184_SNP [dm6]	T	C	9.770e^-7	0.242	INTRON tow
3R	14086481	3R_14086481_SNP [dm3] 3R_18260759_SNP [dm6]	A	G	1.061e^-6	0.242	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_HSA
3R	14086486	3R_14086486_SNP [dm3] 3R_18260764_SNP [dm6]	T	C	1.061e^-6	0.242	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_HSA
3R	14086487	3R_14086487_SNP [dm3] 3R_18260765_SNP [dm6]	A	T	1.061e^-6	0.242	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_HSA
3L	8165729	3L_8165729_SNP [dm3] 3L_8172629_SNP [dm6]	T	C	1.997e^-6	0.404	NON_SYNONYMOUS_CODING RecQ4
3R	6038931	3R_6038931_SNP [dm3] 3R_10213209_SNP [dm6]	G	A	2.474e^-6	0.451	UPSTREAM Timp INTRON Syn	TF binding site BDTNP1_TFBS_z
3L	6941288	3L_6941288_SNP [dm3] 3L_6948188_SNP [dm6]	C	A	2.737e^-6	0.453	INTRON tow
3R	13847623	3R_13847623_SNP [dm3] 3R_18021901_SNP [dm6]	T	G	3.245e^-6	0.492	DOWNSTREAM DNaseII INTRON CG7785	TF binding site BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_bab1 mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Ubx mE1_TFBS_zfh1
X	9439632	X_9439632_SNP [dm3] X_9545599_SNP [dm6]	T	C	3.780e^-6	0.529	INTRON CG32700
3L	8821736	3L_8821736_SNP [dm3] 3L_8828636_SNP [dm6]	G	C	4.335e^-6	0.56	INTRON dally	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_tll BDTNP1_TFBS_twi mE1_TFBS_cad
X	14512200	X_14512200_SNP [dm3] X_14618167_SNP [dm6]	G	A	4.614e^-6	0.56	INTRON NetA
3L	6941338	3L_6941338_SNP [dm3] 3L_6948238_SNP [dm6]	T	G	5.930e^-6	0.675	INTRON tow
2R	7045699	2R_7045699_SNP [dm3] 2R_11158194_SNP [dm6]	A	T	7.078e^-6	0.758	UPSTREAM shn INTRON CG13229
X	10329980	X_10329980_SNP [dm3] X_10435947_SNP [dm6]	C	T	8.773e^-6	0.778	INTRON CG32683
2R	16394972	2R_16394972_INS [dm3] 2R_20507467_INS [dm6]	G	GGA	8.871e^-6	0.778	DOWNSTREAM CR44645 INTERGENIC
3R	15335263	3R_15335263_SNP [dm3] 3R_19509541_SNP [dm6]	C	T	9.455e^-6	0.778	INTRON Dys
2L	5539400	2L_5539400_INS [dm3] 2L_5539400_INS [dm6]	A	TTAT	9.670e^-6	0.778	UTR_3_PRIME Hel25E UPSTREAM CG14015 DOWNSTREAM Hel25E
3R	23884924	3R_23884924_INS [dm3] 3R_28059202_INS [dm6]	A	AAT	1.012e^-5	0.778	INTRON CG34362
X	10330013	X_10330013_SNP [dm3] X_10435980_SNP [dm6]	G	A	1.021e^-5	0.778	INTRON CG32683
3L	20452276	3L_20452276_SNP [dm3] 3L_20459176_SNP [dm6]	G	A	1.026e^-5	0.778	SYNONYMOUS_CODING CG5195	TF binding site mE1_TFBS_sens
3R	14086469	3R_14086469_SNP [dm3] 3R_18260747_SNP [dm6]	G	A	1.121e^-5	0.797	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_HSA
X	10329977	X_10329977_SNP [dm3] X_10435944_SNP [dm6]	G	A	1.139e^-5	0.797	INTRON CG32683
3R	15335158	3R_15335158_SNP [dm3] 3R_19509436_SNP [dm6]	G	T	1.202e^-5	0.81	INTRON Dys	TF binding site BDTNP1_TFBS_dl
3L	7418739	3L_7418739_SNP [dm3] 3L_7425639_SNP [dm6]	A	G	1.352e^-5	0.812	INTRON CG42458
3R	26586738	3R_26586738_SNP [dm3] 3R_30761016_SNP [dm6]	G	A	1.388e^-5	0.812	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
3R	13847681	3R_13847681_SNP [dm3] 3R_18021959_SNP [dm6]	C	A	1.668e^-5	0.812	DOWNSTREAM DNaseII INTRON CG7785	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_bab1 mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Ubx mE1_TFBS_zfh1
3L	14304528	3L_14304528_SNP [dm3] 3L_14311428_SNP [dm6]	T	A	1.710e^-5	0.812	INTRON fz
2L	5529273	2L_5529273_SNP [dm3] 2L_5529273_SNP [dm6]	C	A	1.716e^-5	0.812	NON_SYNONYMOUS_CODING CG31915 INTRON Cap-D3	TF binding site mE1_TFBS_sens
3R	10019258	3R_10019258_SNP [dm3] 3R_14193536_SNP [dm6]	C	T	1.792e^-5	0.812	INTRON Dop1R1
X	6121792	X_6121792_SNP [dm3] X_6227759_SNP [dm6]	A	G	1.806e^-5	0.812	SYNONYMOUS_CODING CG14446	TF binding site mE1_TFBS_sens
X	14512283	X_14512283_SNP [dm3] X_14618250_SNP [dm6]	C	T	1.898e^-5	0.812	INTRON NetA
2L	8574719	2L_8574719_SNP [dm3] 2L_8574719_SNP [dm6]	T	C	1.956e^-5	0.812	INTRON Sema-1a
3R	14086335	3R_14086335_SNP [dm3] 3R_18260613_SNP [dm6]	C	T	2.013e^-5	0.812	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_HSA
3L	6941269	3L_6941269_SNP [dm3] 3L_6948169_SNP [dm6]	T	G	2.028e^-5	0.812	INTRON tow
3R	15335395	3R_15335395_SNP [dm3] 3R_19509673_SNP [dm6]	G	A	2.045e^-5	0.812	INTRON Dys
3L	14304520	3L_14304520_SNP [dm3] 3L_14311420_SNP [dm6]	T	A	2.064e^-5	0.812	INTRON fz
3R	15334348	3R_15334348_SNP [dm3] 3R_19508626_SNP [dm6]	G	A	2.136e^-5	0.812	UPSTREAM Dys INTRON Dys	TF binding site BDTNP1_TFBS_dl mE1_TFBS_Trl
X	15420129	X_15420129_DEL [dm3] X_15526096_DEL [dm6]	GA	G	2.279e^-5	0.812	INTRON Ac13E
3R	17023367	3R_17023367_DEL [dm3] 3R_21197645_DEL [dm6]	CC	C	2.290e^-5	0.812	INTRON SNF4Agamma
2R	19083570	2R_19083570_SNP [dm3] 2R_23196047_SNP [dm6]	C	A	2.298e^-5	0.812	INTRON CG34371	TF binding site BDTNP1_TFBS_twi
3R	10792059	3R_10792059_MNP [dm3] 3R_14966337_MNP [dm6]	TTTTTTT	GGTAAAC	2.298e^-5	0.812	INTERGENIC
3L	14304529	3L_14304529_SNP [dm3] 3L_14311429_SNP [dm6]	T	C	2.313e^-5	0.812	INTRON fz
3R	26571027	3R_26571027_SNP [dm3] 3R_30745305_SNP [dm6]	A	C	2.319e^-5	0.812	UPSTREAM Npc2g DOWNSTREAM CG15543 & 1 other INTERGENIC	TF binding site mE1_TFBS_cad
2L	1934453	2L_1934453_SNP [dm3] 2L_1934453_SNP [dm6]	A	G	2.391e^-5	0.812	INTRON CG7337	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
3L	6941023	3L_6941023_SNP [dm3] 3L_6947923_SNP [dm6]	C	T	2.591e^-5	0.812	SPLICE_SITE_REGION tow INTRON tow
3R	26673129	3R_26673129_SNP [dm3] 3R_30847407_SNP [dm6]	A	G	2.596e^-5	0.812	INTERGENIC
3L	14304537	3L_14304537_SNP [dm3] 3L_14311437_SNP [dm6]	G	A	2.709e^-5	0.812	INTRON fz
X	10329994	X_10329994_SNP [dm3] X_10435961_SNP [dm6]	C	T	2.780e^-5	0.812	INTRON CG32683
3R	14458388	3R_14458388_SNP [dm3] 3R_18632666_SNP [dm6]	G	T	2.817e^-5	0.812	INTRON qin & 1 other
3R	22624942	3R_22624942_SNP [dm3] 3R_26799220_SNP [dm6]	G	T	2.881e^-5	0.812	UTR_5_PRIME Tl	regulatory region REDfly_CRMs TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med mE1_TFBS_HSA mE1_TFBS_Trl
3R	23915084	3R_23915084_SNP [dm3] 3R_28089362_SNP [dm6]	T	G	2.924e^-5	0.812	UTR_3_PRIME CG34362
2L	20422456	2L_20422456_SNP [dm3] 2L_20422456_SNP [dm6]	G	A	2.956e^-5	0.812	DOWNSTREAM snoRNA:Psi18S-640f & 4 others INTRON Arpc2	TF binding site mE1_TFBS_kn
3R	13620350	3R_13620350_SNP [dm3] 3R_17794628_SNP [dm6]	G	T	3.026e^-5	0.812	UPSTREAM CG7713 & 1 other INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi
2L	5426727	2L_5426727_SNP [dm3] 2L_5426727_SNP [dm6]	T	A	3.037e^-5	0.812	INTERGENIC
3R	22658298	3R_22658298_SNP [dm3] 3R_26832576_SNP [dm6]	G	C	3.084e^-5	0.812	INTRON Tl
3L	9230749	3L_9230749_SNP [dm3] 3L_9237649_SNP [dm6]	A	C	3.291e^-5	0.812	INTERGENIC
2L	1136489	2L_1136489_SNP [dm3] 2L_1136489_SNP [dm6]	A	T	3.293e^-5	0.812	INTRON CG4577
2R	7651359	2R_7651359_SNP [dm3] 2R_11763854_SNP [dm6]	C	T	3.307e^-5	0.812	INTRON ths
3R	15334577	3R_15334577_SNP [dm3] 3R_19508855_SNP [dm6]	C	T	3.314e^-5	0.812	UPSTREAM Dys INTRON Dys	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA mE1_TFBS_Trl
3R	17595350	3R_17595350_SNP [dm3] 3R_21769628_SNP [dm6]	T	C	3.367e^-5	0.812	SYNONYMOUS_CODING Burs DOWNSTREAM CG42335 & 1 other
X	20370474	X_20370474_SNP [dm3] X_20499447_SNP [dm6]	A	G	3.415e^-5	0.812	INTRON RhoGAP19D
3R	9759415	3R_9759415_SNP [dm3] 3R_13933693_SNP [dm6]	T	C	3.565e^-5	0.812	INTERGENIC	TF binding site BDTNP1_TFBS_da mE1_TFBS_cad
2L	8662192	2L_8662192_SNP [dm3] 2L_8662192_SNP [dm6]	G	A	3.617e^-5	0.812	INTRON Sema-1a
3R	10629418	3R_10629418_SNP [dm3] 3R_14803696_SNP [dm6]	G	A	3.625e^-5	0.812	SYNONYMOUS_CODING CG14857 DOWNSTREAM btsz	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
3L	1040585	3L_1040585_SNP [dm3] 3L_1040585_SNP [dm6]	T	C	3.706e^-5	0.812	INTRON bab1	TF binding site mE1_TFBS_cad
3R	12668337	3R_12668337_SNP [dm3] 3R_16842615_SNP [dm6]	A	G	3.775e^-5	0.812	INTRON iab-8	TF binding site BDTNP1_TFBS_twi
3R	9612637	3R_9612637_SNP [dm3] 3R_13786915_SNP [dm6]	G	C	3.783e^-5	0.812	UPSTREAM CR45590 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo
2R	16316038	2R_16316038_SNP [dm3] 2R_20428533_SNP [dm6]	G	T	3.804e^-5	0.812	INTRON CG12484
3R	26591803	3R_26591803_SNP [dm3] 3R_30766081_SNP [dm6]	G	A	3.805e^-5	0.812	UTR_5_PRIME zfh1	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_sens mE1_TFBS_Trl
3R	15334341	3R_15334341_SNP [dm3] 3R_19508619_SNP [dm6]	A	T	3.869e^-5	0.812	UPSTREAM Dys INTRON Dys	TF binding site BDTNP1_TFBS_dl mE1_TFBS_Trl
X	2785659	X_2785659_INS [dm3] X_2891626_INS [dm6]	A	TT	4.004e^-5	0.812	INTRON kirre & 1 other
X	7758843	X_7758843_SNP [dm3] X_7864810_SNP [dm6]	T	C	4.021e^-5	0.812	DOWNSTREAM Ir7b INTERGENIC
3L	5898027	3L_5898027_SNP [dm3] 3L_5904927_SNP [dm6]	C	T	4.160e^-5	0.812	SYNONYMOUS_CODING CG10486 UTR_3_PRIME CG10486 UPSTREAM CG32413
X	10329895	X_10329895_DEL [dm3] X_10435862_DEL [dm6]	CTC	C	4.175e^-5	0.812	INTRON CG32683
2R	14991990	2R_14991990_DEL [dm3] 2R_19104485_DEL [dm6]	ATATAAAACCG...	A	4.229e^-5	0.812	INTRON 5-HT1A
X	10330005	X_10330005_SNP [dm3] X_10435972_SNP [dm6]	G	C	4.266e^-5	0.812	INTRON CG32683
3L	14304533	3L_14304533_SNP [dm3] 3L_14311433_SNP [dm6]	A	C	4.353e^-5	0.812	INTRON fz
3R	23941134	3R_23941134_SNP [dm3] 3R_28115412_SNP [dm6]	C	T	4.358e^-5	0.812	INTERGENIC
3R	15551730	3R_15551730_SNP [dm3] 3R_19726008_SNP [dm6]	C	A	4.363e^-5	0.812	INTERGENIC
2R	19083468	2R_19083468_SNP [dm3] 2R_23195945_SNP [dm6]	C	T	4.379e^-5	0.812	INTRON CG34371	TF binding site BDTNP1_TFBS_twi
3R	10822437	3R_10822437_SNP [dm3] 3R_14996715_SNP [dm6]	A	T	4.401e^-5	0.812	INTERGENIC
3L	14325199	3L_14325199_SNP [dm3] 3L_14332099_SNP [dm6]	A	G	4.409e^-5	0.812	INTRON fz
2L	2527298	2L_2527298_SNP [dm3] 2L_2527298_SNP [dm6]	C	T	4.431e^-5	0.812	INTERGENIC	TF binding site mE1_TFBS_cad
3L	6151486	3L_6151486_SNP [dm3] 3L_6158386_SNP [dm6]	C	T	4.451e^-5	0.812	INTRON Cpr65Ay
3R	18276260	3R_18276260_SNP [dm3] 3R_22450538_SNP [dm6]	C	A	4.540e^-5	0.812	INTRON CG34376	TF binding site BDTNP1_TFBS_dl mE1_TFBS_cad
X	9525021	X_9525021_SNP [dm3] X_9630988_SNP [dm6]	C	T	4.591e^-5	0.812	SYNONYMOUS_CODING l_1_G0232 UTR_5_PRIME l_1_G0232	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo
3R	10628865	3R_10628865_SNP [dm3] 3R_14803143_SNP [dm6]	G	A	4.632e^-5	0.812	NON_SYNONYMOUS_CODING CG14857 DOWNSTREAM btsz	TF binding site mE1_TFBS_cad
X	13714877	X_13714877_SNP [dm3] X_13820844_SNP [dm6]	T	A	4.647e^-5	0.812	INTRON Clic	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_inv
2L	2354277	2L_2354277_SNP [dm3] 2L_2354277_SNP [dm6]	A	C	4.717e^-5	0.812	SYNONYMOUS_CODING eys INTRON CG9967	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
2L	17505122	2L_17505122_SNP [dm3] 2L_17505122_SNP [dm6]	C	T	4.724e^-5	0.812	SYNONYMOUS_CODING Dhc36C	TF binding site mE1_TFBS_sens
X	7256198	X_7256198_SNP [dm3] X_7362165_SNP [dm6]	G	A	4.765e^-5	0.812	INTRON CG1677 & 1 other
X	18380790	X_18380790_DEL [dm3] X_18486757_DEL [dm6]	TA	T	4.832e^-5	0.812	UTR_5_PRIME psh DOWNSTREAM CG15046
3L	20453219	3L_20453219_SNP [dm3] 3L_20460119_SNP [dm6]	T	C	4.858e^-5	0.812	UPSTREAM CG5195 & 1 other INTRON CG5195
X	11231672	X_11231672_SNP [dm3] X_11337639_SNP [dm6]	T	A	4.877e^-5	0.812	SYNONYMOUS_CODING Kap3
X	3578051	X_3578051_SNP [dm3] X_3684018_SNP [dm6]	T	C	4.910e^-5	0.812	INTRON Mnt	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
2R	19576165	2R_19576165_SNP [dm3] 2R_23688642_SNP [dm6]	C	T	4.934e^-5	0.812	SYNONYMOUS_CODING Pal2 DOWNSTREAM St3	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA

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By genomic position
Variant impact
Gene name

Aggression_GSEI phenotype

Phenotype distribution and association to known covariates

QQplot

Manhattan plot

GWAS results