DGRPool

GWAS results were computed on dm3 genome.

If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype: DGRP2 results PLINK2 results

Full results

Phenotype distribution and association to known covariates

Shapiro-Wilk test of normality (p-value=1.009e^-3)
Null Hypothesis is rejected (p<=0.05).
Interpretation: NOT NORMAL distribution of this phenotype

We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using both ANOVA and Kruskal-Wallis association tests.

ANOVA test
No significant result.

Kruskal-Wallis test

Covariate	χ²	p-value	Significance
wolba	3.0482	0.0808

PNG PDF

QQplot

PNG PDF

Manhattan plot

GWAS results

1438 significant hits at p-value < 0.001. The 1000 top results are displayed in the table below.

We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001. Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes. GO enrichment FlyBase phenotype enrichment

Variant impact HIGH MODERATE LOW MODIFIER

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Chromosome	Position	ID	Reference	Variant	p-value	FDR_BH	Transcript annotation	Binding site annotation
2L	5747125	2L_5747125_SNP [dm3] 2L_5747125_SNP [dm6]	G	A	3.992e^-7	0.727	SYNONYMOUS_CODING CG11029 INTRON CG11030	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
3R	10936838	3R_10936838_SNP [dm3] 3R_15111116_SNP [dm6]	T	C	2.600e^-6	1	INTRON CG42788
2L	3171289	2L_3171289_SNP [dm3] 2L_3171289_SNP [dm6]	C	T	5.510e^-6	1	UPSTREAM CG44002 EXON CR44003	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_ttk
X	1537890	X_1537890_SNP [dm3] X_1643857_SNP [dm6]	C	T	6.811e^-6	1	UTR_3_PRIME br INTRON Mur2B & 1 other
X	9676881	X_9676881_SNP [dm3] X_9782848_SNP [dm6]	A	G	7.397e^-6	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
X	9676887	X_9676887_SNP [dm3] X_9782854_SNP [dm6]	G	T	7.397e^-6	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
2R	18508738	2R_18508738_SNP [dm3] 2R_22621233_SNP [dm6]	G	A	8.844e^-6	1	INTRON CG33143	TF binding site mE1_TFBS_HSA mE1_TFBS_inv
2R	6451975	2R_6451975_DEL [dm3] 2R_10564470_DEL [dm6]	TCTT	T	1.038e^-5	1	INTRON psq	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_z mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Trl
3L	3350580	3L_3350580_SNP [dm3] 3L_3350580_SNP [dm6]	T	C	1.128e^-5	1	INTRON kst
2R	18508778	2R_18508778_SNP [dm3] 2R_22621273_SNP [dm6]	C	T	1.132e^-5	1	INTRON CG33143	TF binding site mE1_TFBS_HSA mE1_TFBS_inv
3L	594329	3L_594329_INS [dm3] 3L_594329_INS [dm6]	G	GACTTA	1.178e^-5	1	INTRON MED14	TF binding site mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_sens
3L	4276320	3L_4276320_SNP [dm3] 3L_4276320_SNP [dm6]	A	T	1.431e^-5	1	NON_SYNONYMOUS_CODING CG1273	TF binding site mE1_TFBS_sens
X	21138010	X_21138010_SNP [dm3] X_21266983_SNP [dm6]	T	C	1.670e^-5	1	INTRON CG32521
3R	15639351	3R_15639351_SNP [dm3] 3R_19813629_SNP [dm6]	A	G	1.784e^-5	1	INTRON bnl
X	1535746	X_1535746_INS [dm3] X_1641713_INS [dm6]	A	ACA	1.850e^-5	1	INTRON Mur2B & 1 other
2L	5746522	2L_5746522_SNP [dm3] 2L_5746522_SNP [dm6]	T	C	1.852e^-5	1	SYNONYMOUS_CODING CG11029 INTRON CG11030	TF binding site mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
2L	4580044	2L_4580044_SNP [dm3] 2L_4580044_SNP [dm6]	G	C	2.017e^-5	1	INTRON dp
3L	13242551	3L_13242551_SNP [dm3] 3L_13249451_SNP [dm6]	T	C	2.122e^-5	1	UPSTREAM tRNA:D2:69F & 1 other INTRON caps
X	9676950	X_9676950_SNP [dm3] X_9782917_SNP [dm6]	A	T	2.238e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3R	26787161	3R_26787161_SNP [dm3] 3R_30961439_SNP [dm6]	C	A	2.308e^-5	1	NON_SYNONYMOUS_CODING CG15548
X	9676946	X_9676946_SNP [dm3] X_9782913_SNP [dm6]	G	A	2.349e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3R	5167703	3R_5167703_SNP [dm3] 3R_9341981_SNP [dm6]	T	G	2.459e^-5	1	START_GAINED CG45050 UTR_5_PRIME CG45050 INTRON CG45050	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_cad mE1_TFBS_HSA mE1_TFBS_Trl
2L	10152765	2L_10152765_SNP [dm3] 2L_10152765_SNP [dm6]	T	G	2.469e^-5	1	SYNONYMOUS_CODING CG4839 INTRON CG44153
X	8094070	X_8094070_SNP [dm3] X_8200037_SNP [dm6]	T	C	2.472e^-5	1	INTRON sdt
X	9676917	X_9676917_SNP [dm3] X_9782884_SNP [dm6]	T	A	2.492e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3L	5662414	3L_5662414_SNP [dm3] 3L_5669314_SNP [dm6]	C	A	2.614e^-5	1	INTRON sif
2R	19661127	2R_19661127_SNP [dm3] 2R_23773604_SNP [dm6]	C	T	2.664e^-5	1	INTRON CG9850
2R	19354652	2R_19354652_SNP [dm3] 2R_23467129_SNP [dm6]	A	G	2.791e^-5	1	SYNONYMOUS_CODING CG43795	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
2R	17237138	2R_17237138_SNP [dm3] 2R_21349633_SNP [dm6]	G	A	2.803e^-5	1	INTRON CG17974
3L	13094288	3L_13094288_SNP [dm3] 3L_13101188_SNP [dm6]	A	T	2.956e^-5	1	DOWNSTREAM CR44554 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
3R	23167552	3R_23167552_SNP [dm3] 3R_27341830_SNP [dm6]	T	A	2.998e^-5	1	INTRON CG42534
3L	11535158	3L_11535158_SNP [dm3] 3L_11542058_SNP [dm6]	C	A	3.076e^-5	1	NON_SYNONYMOUS_CODING Mob2 INTRON Mob2
X	6422740	X_6422740_SNP [dm3] X_6528707_SNP [dm6]	T	A	3.129e^-5	1	UPSTREAM CG3342 & 1 other INTERGENIC
X	9676923	X_9676923_SNP [dm3] X_9782890_SNP [dm6]	A	C	3.214e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3R	26786466	3R_26786466_SNP [dm3] 3R_30960744_SNP [dm6]	A	G	3.217e^-5	1	NON_SYNONYMOUS_CODING CG15548
X	9676930	X_9676930_SNP [dm3] X_9782897_SNP [dm6]	T	G	3.218e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
X	3237800	X_3237800_SNP [dm3] X_3343767_SNP [dm6]	T	A	3.229e^-5	1	UTR_3_PRIME dnc INTRON CR44886	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_z mE1_TFBS_bab1 mE1_TFBS_hkb mE1_TFBS_HSA mE1_TFBS_zfh1
X	3342685	X_3342685_SNP [dm3] X_3448652_SNP [dm6]	C	T	3.347e^-5	1	INTRON CR44999 & 1 other	TF binding site BDTNP1_TFBS_prd
3R	21021221	3R_21021221_SNP [dm3] 3R_25195499_SNP [dm6]	A	T	3.378e^-5	1	UPSTREAM CG13653 INTERGENIC	TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_da BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_kni BDTNP1_TFBS_Med BDTNP1_TFBS_sna BDTNP1_TFBS_tll BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2R	17834155	2R_17834155_SNP [dm3] 2R_21946650_SNP [dm6]	G	A	3.418e^-5	1	DOWNSTREAM Fili INTERGENIC
2R	13138217	2R_13138217_SNP [dm3] 2R_17250712_SNP [dm6]	C	T	3.820e^-5	1	INTRON mbl
3R	15639567	3R_15639567_SNP [dm3] 3R_19813845_SNP [dm6]	C	T	3.846e^-5	1	INTRON bnl
X	21440323	X_21440323_DEL [dm3] X_21569296_DEL [dm6]	AA	C	3.891e^-5	1	INTERGENIC
3L	13242568	3L_13242568_SNP [dm3] 3L_13249468_SNP [dm6]	C	T	3.978e^-5	1	UPSTREAM tRNA:D2:69F & 1 other INTRON caps
2L	4580188	2L_4580188_SNP [dm3] 2L_4580188_SNP [dm6]	C	T	4.144e^-5	1	INTRON dp
3L	13094269	3L_13094269_SNP [dm3] 3L_13101169_SNP [dm6]	G	A	4.275e^-5	1	DOWNSTREAM CR44554 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
2L	761162	2L_761162_SNP [dm3] 2L_761162_SNP [dm6]	G	T	4.432e^-5	1	UTR_3_PRIME GABA-B-R3
2R	17083552	2R_17083552_DEL [dm3] 2R_21196047_DEL [dm6]	AA	A	4.452e^-5	1	INTRON Lapsyn
X	9676932	X_9676932_DEL [dm3] X_9782899_DEL [dm6]	TG	T	4.569e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC	TF binding site mE1_TFBS_cad mE1_TFBS_HSA
3R	16009296	3R_16009296_INS [dm3] 3R_20183574_INS [dm6]	C	CA	4.575e^-5	1	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	4276327	3L_4276327_SNP [dm3] 3L_4276327_SNP [dm6]	T	A	4.685e^-5	1	NON_SYNONYMOUS_CODING CG1273	TF binding site mE1_TFBS_sens
2R	13245690	2R_13245690_SNP [dm3] 2R_17358185_SNP [dm6]	G	A	4.739e^-5	1	INTRON mbl
3L	20100738	3L_20100738_SNP [dm3] 3L_20107638_SNP [dm6]	C	T	4.827e^-5	1	DOWNSTREAM Ir76b & 1 other INTERGENIC	TF binding site BDTNP1_TFBS_dl mE1_TFBS_HSA
2L	4898739	2L_4898739_SNP [dm3] 2L_4898739_SNP [dm6]	A	C	4.931e^-5	1	INTRON CG3036
X	16718268	X_16718268_SNP [dm3] X_16824235_SNP [dm6]	T	C	4.949e^-5	1	INTRON CG4829
3L	13094196	3L_13094196_SNP [dm3] 3L_13101096_SNP [dm6]	T	A	4.971e^-5	1	DOWNSTREAM CR44554 INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA
3L	5522478	3L_5522478_DEL [dm3] 3L_5529378_DEL [dm6]	TT	T	4.977e^-5	1	UPSTREAM Lkr INTERGENIC
3L	5175478	3L_5175478_SNP [dm3] 3L_5182378_SNP [dm6]	A	G	4.990e^-5	1	INTRON shep
3L	5175489	3L_5175489_SNP [dm3] 3L_5182389_SNP [dm6]	G	T	4.990e^-5	1	INTRON shep
3L	5175514	3L_5175514_SNP [dm3] 3L_5182414_SNP [dm6]	G	A	4.990e^-5	1	INTRON shep
3L	5175547	3L_5175547_SNP [dm3] 3L_5182447_SNP [dm6]	A	G	4.990e^-5	1	INTRON shep
X	4042038	X_4042038_SNP [dm3] X_4148005_SNP [dm6]	T	C	5.104e^-5	1	INTRON Fas2	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
X	4042041	X_4042041_SNP [dm3] X_4148008_SNP [dm6]	T	G	5.104e^-5	1	INTRON Fas2	TF binding site mE1_TFBS_HSA mE1_TFBS_sens
2R	19354643	2R_19354643_SNP [dm3] 2R_23467120_SNP [dm6]	C	T	5.289e^-5	1	SYNONYMOUS_CODING CG43795	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
X	18513928	X_18513928_SNP [dm3] X_18619895_SNP [dm6]	A	T	5.402e^-5	1	INTERGENIC	transposable element FlyBase
3R	21668218	3R_21668218_SNP [dm3] 3R_25842496_SNP [dm6]	C	G	5.468e^-5	1	NON_SYNONYMOUS_CODING alpha4GT2
3R	12427818	3R_12427818_SNP [dm3] 3R_16602096_SNP [dm6]	C	G	5.473e^-5	1	INTRON CG10345
3R	24431865	3R_24431865_SNP [dm3] 3R_28606143_SNP [dm6]	A	T	6.100e^-5	1	UTR_5_PRIME CG9986 DOWNSTREAM Hrb98DE	TF binding site BDTNP1_TFBS_dl
2L	14983302	2L_14983302_SNP [dm3] 2L_14983302_SNP [dm6]	C	A	6.107e^-5	1	INTRON mol
X	9424899	X_9424899_SNP [dm3] X_9530866_SNP [dm6]	G	A	6.114e^-5	1	INTRON CG32700
3R	21021287	3R_21021287_SNP [dm3] 3R_25195565_SNP [dm6]	G	A	6.337e^-5	1	SYNONYMOUS_CODING CG13653	TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_tll BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
2R	9269184	2R_9269184_SNP [dm3] 2R_13381679_SNP [dm6]	G	T	6.359e^-5	1	INTERGENIC
2R	9269187	2R_9269187_SNP [dm3] 2R_13381682_SNP [dm6]	C	T	6.359e^-5	1	INTERGENIC
2R	9269189	2R_9269189_SNP [dm3] 2R_13381684_SNP [dm6]	C	T	6.359e^-5	1	INTERGENIC
2R	9269191	2R_9269191_SNP [dm3] 2R_13381686_SNP [dm6]	C	T	6.359e^-5	1	INTERGENIC
2R	9269192	2R_9269192_SNP [dm3] 2R_13381687_SNP [dm6]	T	C	6.359e^-5	1	INTERGENIC
2R	14675993	2R_14675993_SNP [dm3] 2R_18788488_SNP [dm6]	C	T	6.388e^-5	1	INTRON CG15080
3R	5045868	3R_5045868_DEL [dm3] 3R_9220146_DEL [dm6]	AGAATAA	A	6.480e^-5	1	INTRON pum	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi BDTNP1_TFBS_z mE1_TFBS_D mE1_TFBS_HSA mE1_TFBS_Trl
3R	12493888	3R_12493888_SNP [dm3] 3R_16668166_SNP [dm6]	T	G	6.593e^-5	1	INTRON Ubx	TF binding site mE1_TFBS_HSA
3L	20176231	3L_20176231_SNP [dm3] 3L_20183131_SNP [dm6]	T	A	6.628e^-5	1	INTRON CG42674	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
X	17916202	X_17916202_DEL [dm3] X_18022169_DEL [dm6]	TG	T	6.829e^-5	1	INTRON Sh
2R	19354679	2R_19354679_SNP [dm3] 2R_23467156_SNP [dm6]	T	G	6.890e^-5	1	SYNONYMOUS_CODING CG43795	TF binding site mE1_TFBS_chinmo mE1_TFBS_HSA
X	18514141	X_18514141_SNP [dm3] X_18620108_SNP [dm6]	G	A	6.895e^-5	1	INTERGENIC
3R	24431869	3R_24431869_SNP [dm3] 3R_28606147_SNP [dm6]	C	A	6.971e^-5	1	UTR_5_PRIME CG9986 DOWNSTREAM Hrb98DE	TF binding site BDTNP1_TFBS_dl
3L	12850753	3L_12850753_SNP [dm3] 3L_12857653_SNP [dm6]	A	G	7.081e^-5	1	UTR_3_PRIME CG32107 DOWNSTREAM Ent3	TF binding site mE1_TFBS_HSA mE1_TFBS_kn
2L	3562565	2L_3562565_SNP [dm3] 2L_3562565_SNP [dm6]	G	A	7.083e^-5	1	DOWNSTREAM CR44747 EXON CR44309
2L	3562572	2L_3562572_SNP [dm3] 2L_3562572_SNP [dm6]	A	C	7.083e^-5	1	DOWNSTREAM CR44747 EXON CR44309
X	9676859	X_9676859_SNP [dm3] X_9782826_SNP [dm6]	C	G	7.139e^-5	1	UPSTREAM CG32698 DOWNSTREAM CG1354 INTERGENIC
X	10088575	X_10088575_SNP [dm3] X_10194542_SNP [dm6]	C	G	7.431e^-5	1	UTR_3_PRIME CG43902 INTRON CR44894
3R	10120898	3R_10120898_SNP [dm3] 3R_14295176_SNP [dm6]	A	G	7.511e^-5	1	INTRON CG12207
3R	9297014	3R_9297014_SNP [dm3] 3R_13471292_SNP [dm6]	A	T	7.628e^-5	1	INTERGENIC
3R	12042922	3R_12042922_SNP [dm3] 3R_16217200_SNP [dm6]	T	A	7.638e^-5	1	INTERGENIC	TF binding site BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
3R	18848584	3R_18848584_SNP [dm3] 3R_23022862_SNP [dm6]	G	T	7.729e^-5	1	INTRON lmd	TF binding site BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
3L	10780411	3L_10780411_SNP [dm3] 3L_10787311_SNP [dm6]	A	T	7.738e^-5	1	INTERGENIC
X	559628	X_559628_SNP [dm3] X_665595_SNP [dm6]	T	G	7.796e^-5	1	INTERGENIC	transposable element FlyBase
3L	9004191	3L_9004191_SNP [dm3] 3L_9011091_SNP [dm6]	G	A	7.822e^-5	1	INTERGENIC	TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
3L	9004239	3L_9004239_INS [dm3] 3L_9011139_INS [dm6]	C	GA	7.822e^-5	1	INTERGENIC	TF binding site BDTNP1_TFBS_bcd BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_gt BDTNP1_TFBS_Med BDTNP1_TFBS_prd BDTNP1_TFBS_sna BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
X	16718284	X_16718284_SNP [dm3] X_16824251_SNP [dm6]	G	A	7.946e^-5	1	INTRON CG4829
2L	14399917	2L_14399917_SNP [dm3] 2L_14399917_SNP [dm6]	A	C	7.992e^-5	1	INTRON elB
2R	16477791	2R_16477791_DEL [dm3] 2R_20590286_DEL [dm6]	GAAG	G	8.037e^-5	1	INTRON bl	TF binding site BDTNP1_TFBS_dl BDTNP1_TFBS_twi mE1_TFBS_HSA

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By genomic position
Variant impact
Gene name

se_Aggressi_Isolated phenotype

Phenotype distribution and association to known covariates

QQplot

Manhattan plot

GWAS results