©2022-2025 Deplancke lab, EPFL, 1015 Lausanne
Filters
| By genomic position | |
| Variant impact | |
| Gene name |
| Involved in binding site | |
| Binding site |
GWAS results were computed on dm3 genome.
If you want to make an independent analysis with DGRP2 or PLINK2, you can find here prepared input files for this phenotype:
DGRP2 results
PLINK2 results
Phenotype distribution and association to known covariates
Shapiro-Wilk test of normality (p-value=3.281e-1)
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype
Null hypothesis is not rejected (p>0.05).
Interpretation: NORMAL distribution of this phenotype
We tested for association of this phenotype with 6 known covariates Huang et al., 2014 using
both ANOVA and Kruskal-Wallis association tests.
GWAS results
1606
significant hits at p-value < 0.001.
The 1000 top results are displayed in the table below.
We performed a gene enrichment calculation (Fisher's exact test) of all GWAS-associated genes at p < 0.001.
Genesets were taken from two database: the Gene Ontology (GO) and the FlyBase phenotypes.
GO enrichment
FlyBase phenotype enrichment
Variant impact HIGH MODERATE LOW MODIFIER
| Chromosome | Position | ID | Reference | Variant | p-value | FDR_BH | Transcript annotation | Binding site annotation | |
|---|---|---|---|---|---|---|---|---|---|
| 2L | 1632386 | 2L_1632386_SNP [dm3] 2L_1632386_SNP [dm6] | A | T | 1.186e-6 | 1 |
INTERGENIC
|
||
| 3L | 18810814 | 3L_18810814_SNP [dm3] 3L_18817714_SNP [dm6] | T | C | 1.394e-6 | 1 |
INTRON
CG14073 |
||
| 3R | 19071977 | 3R_19071977_SNP [dm3] 3R_23246255_SNP [dm6] | G | A | 3.268e-6 | 1 |
INTRON
CG4467 |
||
| 3L | 1966180 | 3L_1966180_SNP [dm3] 3L_1966180_SNP [dm6] | G | A | 4.149e-6 | 1 |
SYNONYMOUS_CODING
SCOT DOWNSTREAM CG1927 |
TF binding site
mE1_TFBS_chinmo
|
|
| 2R | 14328176 | 2R_14328176_DEL [dm3] 2R_18440671_DEL [dm6] | TTT | T | 4.190e-6 | 1 |
UPSTREAM
slim & 1 other INTERGENIC |
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA
|
|
| 2L | 1632388 | 2L_1632388_SNP [dm3] 2L_1632388_SNP [dm6] | T | A | 4.736e-6 | 1 |
INTERGENIC
|
||
| 3L | 8650506 | 3L_8650506_SNP [dm3] 3L_8657406_SNP [dm6] | T | G | 4.840e-6 | 1 |
INTERGENIC
|
||
| 3L | 7936243 | 3L_7936243_SNP [dm3] 3L_7943143_SNP [dm6] | A | T | 5.012e-6 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_cad
|
|
| 2R | 15816475 | 2R_15816475_SNP [dm3] 2R_19928970_SNP [dm6] | G | A | 5.420e-6 | 1 |
INTERGENIC
|
||
| 3L | 18140585 | 3L_18140585_SNP [dm3] 3L_18147485_SNP [dm6] | T | G | 5.842e-6 | 1 |
INTERGENIC
|
||
| 2L | 10315909 | 2L_10315909_SNP [dm3] 2L_10315909_SNP [dm6] | C | T | 8.651e-6 | 1 |
SYNONYMOUS_CODING
CG4972 |
TF binding site
mE1_TFBS_sens
|
|
| 2L | 10592611 | 2L_10592611_SNP [dm3] 2L_10592611_SNP [dm6] | A | T | 9.914e-6 | 1 |
INTRON
Trim9 |
||
| 2L | 1696065 | 2L_1696065_SNP [dm3] 2L_1696065_SNP [dm6] | T | G | 1.181e-5 | 1 |
SYNONYMOUS_CODING
chinmo |
TF binding site
mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
|
|
| 3R | 25189263 | 3R_25189263_SNP [dm3] 3R_29363541_SNP [dm6] | T | C | 1.352e-5 | 1 |
INTERGENIC
|
||
| X | 604933 | X_604933_SNP [dm3] X_710900_SNP [dm6] | T | G | 1.359e-5 | 1 |
INTRON
sdk |
transposable element
FlyBase
|
|
| 2L | 1835028 | 2L_1835028_SNP [dm3] 2L_1835028_SNP [dm6] | T | G | 1.428e-5 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_inv
|
|
| 3L | 18380973 | 3L_18380973_SNP [dm3] 3L_18387873_SNP [dm6] | C | T | 1.476e-5 | 1 |
INTERGENIC
|
||
| 3R | 15340424 | 3R_15340424_SNP [dm3] 3R_19514702_SNP [dm6] | G | T | 1.556e-5 | 1 |
INTRON
Dys |
||
| 2R | 13739507 | 2R_13739507_INS [dm3] 2R_17852002_INS [dm6] | T | TTGTAC | 1.918e-5 | 1 |
INTRON
olf186-F |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_run mE1_TFBS_Trl
|
|
| 3R | 15338813 | 3R_15338813_SNP [dm3] 3R_19513091_SNP [dm6] | T | C | 2.002e-5 | 1 |
INTRON
Dys |
||
| 2R | 17780750 | 2R_17780750_SNP [dm3] 2R_21893245_SNP [dm6] | C | T | 2.132e-5 | 1 |
INTRON
Fili |
||
| 3L | 15625572 | 3L_15625572_SNP [dm3] 3L_15632472_SNP [dm6] | T | G | 2.176e-5 | 1 |
UTR_5_PRIME
comm3 INTRON comm3 |
||
| X | 601759 | X_601759_SNP [dm3] X_707726_SNP [dm6] | T | G | 2.308e-5 | 1 |
INTRON
sdk |
||
| 3L | 11792808 | 3L_11792808_SNP [dm3] 3L_11799708_SNP [dm6] | G | A | 2.366e-5 | 1 |
SYNONYMOUS_CODING
CG10361 DOWNSTREAM Klp68D |
TF binding site
mE1_TFBS_HSA
|
|
| 3R | 15338694 | 3R_15338694_SNP [dm3] 3R_19512972_SNP [dm6] | C | T | 2.468e-5 | 1 |
INTRON
Dys |
||
| 3R | 15338014 | 3R_15338014_SNP [dm3] 3R_19512292_SNP [dm6] | T | C | 2.510e-5 | 1 |
INTRON
Dys |
||
| 3L | 5320475 | 3L_5320475_SNP [dm3] 3L_5327375_SNP [dm6] | C | T | 2.554e-5 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_inv
|
|
| 3L | 9507749 | 3L_9507749_SNP [dm3] 3L_9514649_SNP [dm6] | A | T | 2.640e-5 | 1 |
SYNONYMOUS_CODING
CG33700 UPSTREAM CR33701 |
||
| 3R | 15338010 | 3R_15338010_SNP [dm3] 3R_19512288_SNP [dm6] | G | C | 2.757e-5 | 1 |
INTRON
Dys |
||
| 3L | 18856095 | 3L_18856095_SNP [dm3] 3L_18862995_SNP [dm6] | G | C | 2.824e-5 | 1 |
UPSTREAM
CG6865 INTERGENIC |
||
| 3L | 5320154 | 3L_5320154_SNP [dm3] 3L_5327054_SNP [dm6] | A | G | 2.910e-5 | 1 |
INTERGENIC
|
||
| 3L | 1827971 | 3L_1827971_SNP [dm3] 3L_1827971_SNP [dm6] | T | G | 2.999e-5 | 1 |
INTRON
Cpr62Ba |
||
| 2R | 19565223 | 2R_19565223_SNP [dm3] 2R_23677700_SNP [dm6] | C | T | 3.020e-5 | 1 |
INTRON
Pde8 |
TF binding site
mE1_TFBS_cad
|
|
| 3L | 5320661 | 3L_5320661_SNP [dm3] 3L_5327561_SNP [dm6] | G | A | 3.103e-5 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_HSA mE1_TFBS_inv
|
|
| 2R | 7526582 | 2R_7526582_SNP [dm3] 2R_11639077_SNP [dm6] | C | T | 3.132e-5 | 1 |
INTRON
CG9005 |
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_hb BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_HSA
|
|
| 3R | 15340252 | 3R_15340252_SNP [dm3] 3R_19514530_SNP [dm6] | C | T | 3.158e-5 | 1 |
INTRON
Dys |
||
| 3R | 23482833 | 3R_23482833_SNP [dm3] 3R_27657111_SNP [dm6] | C | A | 3.287e-5 | 1 |
UTR_3_PRIME
Mlc1 UPSTREAM tau DOWNSTREAM Mlc1 |
||
| 3R | 15330007 | 3R_15330007_SNP [dm3] 3R_19504285_SNP [dm6] | C | T | 3.327e-5 | 1 |
SYNONYMOUS_CODING
Dys INTRON Dys |
TF binding site
BDTNP1_TFBS_sna mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
|
|
| 3L | 5319539 | 3L_5319539_SNP [dm3] 3L_5326439_SNP [dm6] | G | A | 3.454e-5 | 1 |
INTERGENIC
|
||
| 3R | 15338372 | 3R_15338372_SNP [dm3] 3R_19512650_SNP [dm6] | G | T | 3.534e-5 | 1 |
INTRON
Dys |
||
| 2R | 14583678 | 2R_14583678_SNP [dm3] 2R_18696173_SNP [dm6] | G | A | 3.584e-5 | 1 |
UPSTREAM
CG15071 INTRON Sik3 |
TF binding site
BDTNP1_TFBS_dl mE1_TFBS_HSA
|
|
| 3L | 1844838 | 3L_1844838_SNP [dm3] 3L_1844838_SNP [dm6] | A | C | 3.604e-5 | 1 |
INTERGENIC
|
||
| 3R | 20102294 | 3R_20102294_INS [dm3] 3R_24276572_INS [dm6] | C | CT | 3.770e-5 | 1 |
UTR_5_PRIME
Orct UPSTREAM Orct DOWNSTREAM Orct2 |
TF binding site
mE1_TFBS_cad
|
|
| 3L | 18856101 | 3L_18856101_SNP [dm3] 3L_18863001_SNP [dm6] | G | A | 3.807e-5 | 1 |
UPSTREAM
CG6865 INTERGENIC |
||
| 3R | 15330031 | 3R_15330031_SNP [dm3] 3R_19504309_SNP [dm6] | A | G | 3.902e-5 | 1 |
SYNONYMOUS_CODING
Dys INTRON Dys |
TF binding site
BDTNP1_TFBS_sna mE1_TFBS_cad mE1_TFBS_chinmo mE1_TFBS_HSA
|
|
| 3R | 25562159 | 3R_25562159_SNP [dm3] 3R_29736437_SNP [dm6] | C | T | 3.925e-5 | 1 |
SPLICE_SITE_REGION
CG7601 UPSTREAM CG7598 INTRON CG7601 |
TF binding site
BDTNP1_TFBS_dl mE1_TFBS_sens mE1_TFBS_Ubx
|
|
| 3L | 18934159 | 3L_18934159_SNP [dm3] 3L_18941059_SNP [dm6] | T | C | 4.026e-5 | 1 |
INTRON
CG32204 |
||
| 2L | 8625364 | 2L_8625364_SNP [dm3] 2L_8625364_SNP [dm6] | C | T | 4.118e-5 | 1 |
INTRON
Sema-1a |
TF binding site
BDTNP1_TFBS_twi mE1_TFBS_HSA
|
|
| 3L | 13001442 | 3L_13001442_SNP [dm3] 3L_13008342_SNP [dm6] | A | T | 4.189e-5 | 1 |
UTR_5_PRIME
CG14117 DOWNSTREAM CG11263 |
||
| 3R | 15326509 | 3R_15326509_SNP [dm3] 3R_19500787_SNP [dm6] | G | C | 4.201e-5 | 1 |
INTRON
Dys |
||
| 3R | 15338039 | 3R_15338039_SNP [dm3] 3R_19512317_SNP [dm6] | G | A | 4.216e-5 | 1 |
INTRON
Dys |
||
| X | 4772869 | X_4772869_SNP [dm3] X_4878836_SNP [dm6] | G | C | 4.441e-5 | 1 |
INTRON
CG42594 |
||
| 2L | 920954 | 2L_920954_SNP [dm3] 2L_920954_SNP [dm6] | T | G | 4.542e-5 | 1 |
INTERGENIC
|
||
| 2L | 12725086 | 2L_12725086_INS [dm3] 2L_12725086_INS [dm6] | T | TT | 4.569e-5 | 1 |
INTRON
MRP |
||
| 3L | 6439040 | 3L_6439040_SNP [dm3] 3L_6445940_SNP [dm6] | A | G | 4.576e-5 | 1 |
INTRON
CG42747 |
||
| 3R | 15337888 | 3R_15337888_INS [dm3] 3R_19512166_INS [dm6] | T | TG | 4.579e-5 | 1 |
INTRON
Dys |
||
| 2L | 12725277 | 2L_12725277_SNP [dm3] 2L_12725277_SNP [dm6] | C | T | 4.663e-5 | 1 |
INTRON
MRP |
||
| 3L | 13116862 | 3L_13116862_SNP [dm3] 3L_13123762_SNP [dm6] | C | T | 4.693e-5 | 1 |
INTERGENIC
|
||
| 2L | 2124857 | 2L_2124857_SNP [dm3] 2L_2124857_SNP [dm6] | C | A | 4.726e-5 | 1 |
INTERGENIC
|
||
| 3R | 11689480 | 3R_11689480_SNP [dm3] 3R_15863758_SNP [dm6] | A | T | 4.860e-5 | 1 |
INTRON
CG31183 |
||
| 2R | 7596202 | 2R_7596202_SNP [dm3] 2R_11708697_SNP [dm6] | T | A | 4.985e-5 | 1 |
INTERGENIC
|
TF binding site
BDTNP1_TFBS_da
|
|
| 2L | 9052204 | 2L_9052204_SNP [dm3] 2L_9052204_SNP [dm6] | C | T | 5.025e-5 | 1 |
UTR_3_PRIME
CG31708 |
||
| 3R | 15341387 | 3R_15341387_SNP [dm3] 3R_19515665_SNP [dm6] | C | T | 5.060e-5 | 1 |
INTRON
Dys |
||
| 3R | 15337839 | 3R_15337839_SNP [dm3] 3R_19512117_SNP [dm6] | G | T | 5.085e-5 | 1 |
INTRON
Dys |
||
| 2R | 13739630 | 2R_13739630_SNP [dm3] 2R_17852125_SNP [dm6] | C | A | 5.116e-5 | 1 |
INTRON
olf186-F |
TF binding site
BDTNP1_TFBS_da BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_run mE1_TFBS_Trl
|
|
| X | 12318467 | X_12318467_DEL [dm3] X_12424434_DEL [dm6] | AA | A | 5.150e-5 | 1 |
INTERGENIC
|
||
| 2R | 18160821 | 2R_18160821_SNP [dm3] 2R_22273316_SNP [dm6] | G | A | 5.243e-5 | 1 |
INTRON
dve |
TF binding site
mE1_TFBS_chinmo
|
|
| 3R | 15326499 | 3R_15326499_SNP [dm3] 3R_19500777_SNP [dm6] | G | A | 5.264e-5 | 1 |
INTRON
Dys |
||
| X | 604932 | X_604932_SNP [dm3] X_710899_SNP [dm6] | T | G | 5.322e-5 | 1 |
INTRON
sdk |
transposable element
FlyBase
|
|
| 2L | 8254728 | 2L_8254728_SNP [dm3] 2L_8254728_SNP [dm6] | A | T | 5.379e-5 | 1 |
INTRON
CG8086 |
TF binding site
BDTNP1_TFBS_twi
|
|
| X | 11132297 | X_11132297_SNP [dm3] X_11238264_SNP [dm6] | C | G | 5.433e-5 | 1 |
INTRON
CG44422 |
||
| X | 5027960 | X_5027960_SNP [dm3] X_5133927_SNP [dm6] | A | T | 5.469e-5 | 1 |
DOWNSTREAM
Rpn13R INTRON rg & 1 other |
||
| 2R | 11039807 | 2R_11039807_SNP [dm3] 2R_15152302_SNP [dm6] | G | T | 5.563e-5 | 1 |
INTERGENIC
|
||
| 3L | 7064026 | 3L_7064026_SNP [dm3] 3L_7070926_SNP [dm6] | T | A | 5.589e-5 | 1 |
INTRON
CG8641 |
||
| 3L | 5320605 | 3L_5320605_SNP [dm3] 3L_5327505_SNP [dm6] | G | A | 5.652e-5 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_HSA mE1_TFBS_inv
|
|
| X | 19642635 | X_19642635_SNP [dm3] X_19748602_SNP [dm6] | T | G | 5.925e-5 | 1 |
UPSTREAM
Alr DOWNSTREAM parvin INTRON Alr |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_cad mE1_TFBS_h mE1_TFBS_HSA
|
|
| 2R | 15967306 | 2R_15967306_SNP [dm3] 2R_20079801_SNP [dm6] | A | C | 6.027e-5 | 1 |
INTERGENIC
|
||
| 3L | 22890307 | 3L_22890307_SNP [dm3] 3L_22897207_SNP [dm6] | A | C | 6.048e-5 | 1 |
DOWNSTREAM
CR44688 & 1 other INTERGENIC |
TF binding site
mE1_TFBS_chinmo
|
|
| X | 2997707 | X_2997707_SNP [dm3] X_3103674_SNP [dm6] | G | C | 6.062e-5 | 1 |
INTRON
kirre |
||
| 2L | 4124618 | 2L_4124618_SNP [dm3] 2L_4124618_SNP [dm6] | G | T | 6.226e-5 | 1 |
DOWNSTREAM
Sr-CI INTERGENIC |
TF binding site
BDTNP1_TFBS_twi
|
|
| 3L | 9399370 | 3L_9399370_SNP [dm3] 3L_9406270_SNP [dm6] | G | A | 6.273e-5 | 1 |
UTR_3_PRIME
CG4022 DOWNSTREAM Cpr67B |
||
| X | 5597580 | X_5597580_SNP [dm3] X_5703547_SNP [dm6] | T | C | 6.280e-5 | 1 |
SYNONYMOUS_CODING
CG4096 |
TF binding site
mE1_TFBS_chinmo
|
|
| 3R | 15375406 | 3R_15375406_SNP [dm3] 3R_19549684_SNP [dm6] | C | G | 6.322e-5 | 1 |
INTRON
Dys |
||
| X | 601573 | X_601573_SNP [dm3] X_707540_SNP [dm6] | G | T | 6.331e-5 | 1 |
INTRON
sdk |
||
| 2R | 13739504 | 2R_13739504_INS [dm3] 2R_17851999_INS [dm6] | A | TCT | 6.639e-5 | 1 |
INTRON
olf186-F |
TF binding site
BDTNP1_TFBS_dl BDTNP1_TFBS_Med BDTNP1_TFBS_twi mE1_TFBS_HSA mE1_TFBS_inv mE1_TFBS_run mE1_TFBS_Trl
|
|
| 2R | 5574450 | 2R_5574450_SNP [dm3] 2R_9686945_SNP [dm6] | T | C | 6.701e-5 | 1 |
INTERGENIC
|
||
| 3L | 5320678 | 3L_5320678_DEL [dm3] 3L_5327578_DEL [dm6] | TA | T | 6.712e-5 | 1 |
INTERGENIC
|
TF binding site
mE1_TFBS_HSA mE1_TFBS_inv
|
|
| 2R | 15750209 | 2R_15750209_SNP [dm3] 2R_19862704_SNP [dm6] | A | G | 6.828e-5 | 1 |
INTERGENIC
|
TF binding site
BDTNP1_TFBS_da mE1_TFBS_HSA
|
|
| X | 2997709 | X_2997709_SNP [dm3] X_3103676_SNP [dm6] | T | G | 6.876e-5 | 1 |
INTRON
kirre |
||
| 2L | 7258591 | 2L_7258591_SNP [dm3] 2L_7258591_SNP [dm6] | T | C | 7.062e-5 | 1 |
DOWNSTREAM
CG31909 INTRON Wnt4 |
TF binding site
mE1_TFBS_zfh1
|
|
| 2R | 16421008 | 2R_16421008_SNP [dm3] 2R_20533503_SNP [dm6] | A | T | 7.097e-5 | 1 |
UPSTREAM
CG18067 DOWNSTREAM CR44651 INTRON CG30154 |
TF binding site
mE1_TFBS_HSA mE1_TFBS_Trl
|
|
| 4 | 213083 | 4_213083_SNP [dm3] 4_192457_SNP [dm6] | A | C | 7.109e-5 | 1 |
INTRON
CG2316 |
||
| 3R | 24748071 | 3R_24748071_SNP [dm3] 3R_28922349_SNP [dm6] | A | T | 7.131e-5 | 1 |
UTR_3_PRIME
Doa UPSTREAM CG11828 DOWNSTREAM Doa |
||
| 4 | 186535 | 4_186535_SNP [dm3] 4_165909_SNP [dm6] | C | T | 7.182e-5 | 1 |
DOWNSTREAM
CG33978 INTRON CG33978 |
||
| 3L | 11359857 | 3L_11359857_SNP [dm3] 3L_11366757_SNP [dm6] | T | C | 7.385e-5 | 1 |
DOWNSTREAM
CR45036 INTERGENIC |
TF binding site
mE1_TFBS_inv
|
|
| 3R | 15345560 | 3R_15345560_SNP [dm3] 3R_19519838_SNP [dm6] | T | A | 7.670e-5 | 1 |
INTRON
Dys |
||
| 3L | 11792799 | 3L_11792799_SNP [dm3] 3L_11799699_SNP [dm6] | C | T | 7.678e-5 | 1 |
SYNONYMOUS_CODING
CG10361 DOWNSTREAM Klp68D |
TF binding site
mE1_TFBS_HSA
|
|
| 3R | 21913681 | 3R_21913681_SNP [dm3] 3R_26087959_SNP [dm6] | G | A | 7.694e-5 | 1 |
INTRON
dys |
||
| 2L | 20313539 | 2L_20313539_SNP [dm3] 2L_20313539_SNP [dm6] | A | G | 7.723e-5 | 1 |
INTRON
spir |
||
| X | 7584146 | X_7584146_SNP [dm3] X_7690113_SNP [dm6] | T | C | 7.737e-5 | 1 |
INTRON
CHES-1-like |
TF binding site
BDTNP1_TFBS_dl mE1_TFBS_Trl
|
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